Mesenchymal Cell News Volume 8.23 | Jun 14 2016

TOP STORY

EZH2 and HDAC9c Regulate Age-Dependent Mesenchymal Stem Cell Differentiation into Osteoblasts and Adipocytes

Investigators investigated the relationship between age, and osteogenic and adipogenic differentiation potential of mesenchymal stem cells by comparing enhancer of zeste homolog 2 (EZH2) and HDAC9c expression in osteoblasts and adipocytes of both human and mice origins to determine whether the EZH2-HDAC9c axis regulates age-associated osteoporosis and obesity. [Stem Cells] Abstract

(Ranked by impact factor of the journal)

IN VITRO

Suppression of Neutrophil-Mediated Tissue Damage – A Novel Skill of Mesenchymal Stem Cells

Investigators report the therapeutic skill of mesenchymal stem cells to suppress unrestrained neutrophil activation and to attenuate severe tissue damage in a murine immune-complex mediated vasculitis model of unbalanced neutrophil activation. [Stem Cells] Abstract

Calcitonin Gene-Related Peptide Is a Key Factor in the Homing of Transplanted Human MSCs to Sites of Spinal Cord Injury

Scientists demonstrated that calcitonin gene-related peptide, a neural peptide synthesized in spinal cord, can dramatically aid the homing of human umbilical cord mesenchymal stem cells in spinal cord-transected spinal cord injury rats. [Sci Rep] Full Article

Overexpression of HSPA1A Enhances the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells via Activation of the Wnt/β-Catenin Signaling Pathway

HSPA1A, which encodes cognate heat shock protein 70, plays important roles in various cellular metabolic pathways. To investigate its effects on osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), its expression level was compared between undifferentiated and differentiated BMSCs. [Sci Rep] Full Article

Differentiation of Human Mesenchymal Stem Cells toward Quality Cartilage Using Fibrinogen-Based Nanofibers

Researchers showed that human adipose derived mesenchymal stem cells establishes significant chondrogenic differentiation and may generate quality cartilage when cultured on 2D and randomly oriented fibrinogen/poly-lactic acid nanofibers compared to 3D sandwich-like environments. [Macromol Biosci] Abstract

Allogeneic Chondrogenically Differentiated Human Mesenchymal Stromal Cells Do Not Induce Immunogenic Responses from T Lymphocytes In Vitro

The authors investigated the interactions between allogeneic chondrogenically differentiated human bone marrow mesenchymal stromal cell pellets and T lymphocytes in vitro. [Cytotherapy] Abstract

Paclitaxel-Releasing Mesenchymal Stromal Cells Inhibit the Growth of Multiple Myeloma Cells in a Dynamic 3D Culture System

This study confirms, by an in vitro 3D dynamic culture system, that Paclitaxel loaded bone marrow mesenchymal stromal cells (PTXr-MSCs) are active on the proliferation of RPMI 8226, a human myeloma cell line. Scientists demonstrated a dramatic suppression of myeloma cell growth by PTXr-MSCs, suggesting that drug loaded MSCs could be a tool to deliver drug into the bone marrow. [Hematol Oncol] Abstract

IN VIVO

Stepwise Differentiation of Mesenchymal Stem Cells Augments Tendon-Like Tissue Formation and Defect Repair In Vivo

Scientists established an efficient approach to induce tenogenesis of bone marrow-derived mesenchymal stem cells, which are the most common seed cells in tendon tissue engineering. [Stem Cells Transl Med] Abstract

Iron Overload Inhibits Osteogenic Commitment and Differentiation of Mesenchymal Stem Cells via the Induction of Ferritin

The authors demonstrated that in response to iron, bone marrow mesenchymal stem cells upregulated the expression of ferritin. Iron overload in mice was associated with elevated ferritin and decreased runt-related transcription factor 2 mRNA levels in compact bone osteoprogenitor cells. [Biochim Biophys Acta] Abstract

Brain Mesenchymal Stem Cells: Physiology and Pathological Implications

Mesenchymal stem cell/pericyte properties such as differentiation capability, as well as immunoregulatory and paracrine effects make them a potential resource in regenerative medicine. [Dev Growth Differ] Abstract

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Bone Biologics Announces Signing of Option to License Revolutionary Bone Growth Factor Nell-1 from UCLA for Use in Osteoporosis

Bone Biologics announced the signing of an option agreement with UCLA, for an opportunity to exclusively license the use of the revolutionary bone growth factor Nell-1 in the treatment of osteoporosis. [Bone Biologics Corp. (Business Wire)] Press Release

Mesoblast Provides Update on Global Heart Failure Program

Mesoblast Limited announced that it has regained full worldwide rights and full strategic flexibility to exploit its mesenchymal precursor cell technology platform for the cardiovascular field. [Mesoblast Ltd.] Download Press Release

NEW 11^th International BMP Conference
October 26-30, 2016
Boston, United States

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NEW Tenure Track Positions – Regenerative Medicine (Lund University)

Postdoctoral Position – MSC Research (GENYO)

PhD Studentship – Vascular Tissue Engineering (Trinity College Dublin)

Faculty Position – Stem Cell Biology and Regenerative Medicine (University of Illinois, College of Medicine)

Postdoctoral Research Fellow – Neurobiology (McLean Hospital/Harvard Medical School)

Postdoctoral Positions – Immunology, Cancer, and Stem Cells (The University of Connecticut)

Postdoctoral Positions – Regenerative Medicine (Gladstone Institutes)

Postdoctoral Position – Bone/Stem Cell Biology (University of California, Los Angeles)

Postdoctoral Fellow – Skeletal Biology (Perelman School of Medicine)

Postdoctoral Scholar – Neurobiology (Penn State College of Medicine)

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