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Pulmonary Cell News| Mesenchymal Cell News 8.33 August 23, 2016 | |
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TOP STORYScientists showed that a hyaluronic acid hydrogel system enables, across a physiological range of extracellular matrix stiffness, the independent co-presentation of the HAVDI adhesive motif from the EC1 domain of N-cadherin and the RGD adhesive motif from fibronectin. [Nat Mater] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROSilk fibroin films decorated with integrin-binding laminin peptide motifs (YIGSR and G-YIGSR) were prepared and employed for in vitro adult stem cell-based neural tissue engineering applications. [ACS Appl Mater Interfaces] Abstract Scientists demonstrated that estrogen-related receptor α (ERRα) binds to response elements on glutaminase (Gls) promoter and affects glutamine anaplerosis through transcriptional induction of Gls. [Stem Cells] Abstract Investigators showed that osteogenesis not only increased both elastic and viscous moduli, but also converted the intracellular viscoelasticity of differentiating human mesenchymal stromal/stem cells from viscous-like to elastic-like. [Sci Rep] Full Article The authors designed and fabricated a microfluidic device and a culture system for hepatic differentiation of mesenchymal stromal cells using their protocol reported previously. [Stem Cell Res Ther] Full Article Secretome of Human Fetal Mesenchymal Stem Cell Ameliorates Replicative Senescence Researchers hypothesized that the bioactive factors secreted by mesenchymal stem cells (MSC) isolated from human fetal tissues (hFMSC), collectively named as hFMSC secretome, could possess beneficial effect on human adult MSC undergoing replicative senescence, thus promoting their capability of proliferation and differentiation. [Stem Cells Dev] Abstract Scientists investigated the maintenance mechanism of bone marrow-mesenchymal stromal cells by studying signaling through the RAGE, which is thought to be activated under various pathological conditions. [Stem Cells Dev] Abstract Human Mesenchymal Stromal Cells Modulate T-Cell Immune Response via Transcriptomic Regulation By using a microarray-based global gene expression profiling system, researchers aimed to decipher the underlying molecular pathways that may mediate the immunosuppressive activity of umbilical cord-derived mesenchymal stromal cells on activated T cells. [Cytotherapy] Abstract Scientists investigated the behavior of adipose-derived mesenchymal stromal/stem cells in the context of a cell-derived matrix so as to model the in vivo physiological microenvironment. [Int J Mol Sci] Full Article IN VIVOInvestigators examined the proliferation and differentiation capacity of irradiated adipose-derived stem cells over time. [Stem Cell Res Ther] Full Article | |
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REVIEWSThe authors critically reviewed the proliferative and differentiation effects of individual herbal extracts on human mesenchymal stromal cells mainly derived from bone marrow and elaborated on the plausible underlying mechanisms of action. [Stem Cell Res Ther] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSTulane Professor Receives Grant to Improve Stem Cell Survival Kim O’Connor, a professor in Tulane University’s Department of Chemical and Biomolecular Engineering, received a three-year $599,638 grant from the National Science Foundation to study ways to improve the survival of mesenchymal stem cells once they are implanted in patients. [Tulane University] Press Release Mesoblast Strengthens Key United States Patent Portfolio for the Treatment of Rheumatic Diseases Mesoblast Limited announced that its intellectual property portfolio covering the use of its mesenchymal precursor cells in the treatment of rheumatic diseases, including rheumatoid arthritis, has been strengthened by the granting of a key patent by the United States Patent and Trademark Office. [Mesoblast Limited (Globe Newswire)] Press Release | |
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POLICY NEWSPutin Appoints Church Historian as Science Minister Russian President Vladimir Putin has appointed a church historian as the country’s new science and education minister. The president announced that Olga Vasilyeva would succeed the current science minister, Dmitry Livanov, who will become presidential envoy on trade and economic relations with Ukraine, according to the Russian news agency Interfax. [Nature News] Editorial Obama’s Science Legacy: Betting Big on Biomedical Science Ambitious bids to map the brain and cure cancer have not boosted overall research funding. [Nature News] Editorial US Personalized-Medicine Industry Takes Hit From Supreme Court Rejections for US patents related to personalized medicine have spiked after recent Supreme Court decisions tightened the rules for such claims, an analysis of more than 39,000 patent applications reveals. [Nature News] Editorial Chemistry Group Throws out Election Results after Fears of Vote Rigging Members of the Society of Biological Inorganic Chemistry are reacting with puzzlement and shock after learning that the results of a recent online leadership election have been thrown out because of voting irregularities—raising concerns over possible manipulation. [ScienceInsider] Editorial Updated: Companies Settle Gene Technology Patent Fight That Was Shrouded in Mystery Illumina Inc. and Oxford Nanopore Technologies have reached a settlement in this legal battle, according to a U.S. International Trade Commission document released last week. Oxford has agreed not to import or sell any product containing a pore with an amino acid sequence at least 68% similar to Mycobacterium smegmatis porin — the protein at the heart of Illumina’s infringement claim — and to destroy any inventory of such products. [ScienceInsider] Editorial Obama’s Science Legacy: Uneven Progress on Scientific Integrity Many researchers who watched Barack Obama’s inauguration in 2009 were thrilled by his pledge to “restore science to its rightful place”. But scientists and legal scholars say that, in many ways, Obama has failed to live up to that lofty promise. [Nature News] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) Asia 2016 Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow/Scientist – Osteoblast Biology (Michigan State University) Postdoctoral Position – Organogenesis and Mesenchymal Stem Cells (University of Southern California) Postdoctoral Position – Tumor Microenvironment in Sarcoma Progression (Universita’ di Bologna) Cell Biologist – Mesenchymal Stem Cells (Biostage) Postdoctoral Position – Bone and Stem Cell Research (University of Connecticut Health) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Mesenchymal Cell News Volume 8.33 | Aug 23 2016
