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Pulmonary Cell News| Mesenchymal Cell News 8.40 October 11, 2016 | |
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TOP STORYIdentification of a Common Mesenchymal Stromal Progenitor for the Adult Hematopoietic Niche On the basis of the differential expression of cell-surface markers, investigators identified a mesenchymal stromal progenitor hierarchy, where progenitors give rise to intermediate and mature osteo-progenitors. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROCancer Cells Enter Dormancy After Cannibalizing Mesenchymal Stem/Stromal Cells (MSCs) Using 3D cocultures to mimic the cellular interactions of an emerging tumor niche, investigators observed that MSCs sequentially surrounded the breast cancer cell, promoted formation of cancer spheroids, and then were internalized/degraded through a process resembling the well-documented yet ill-defined clinical phenomenon of cancer cell cannibalism. This practical 3D coculture model could provide a valuable tool to understand the antitumor activity of MSCs and cell cannibalism. [Proc Natl Acad Sci USA] Abstract Subcellular Cell Geometry on Micropillars Regulates Stem Cell Differentiation Researchers prepared a series of micropillar arrays of poly(lactide-co-glycolide) and discovered a first-order transition of nuclear shape as a function of micropillar height under the examined section area and interspacing of the pillars. The deformed state of the nuclei of mesenchymal stem cells (MSCs) was well maintained even after osteogenic or adipogenic induction for several days. [Biomaterials] Abstract The authors investigated the mechanistic basis underlying the connection between multi-cellular aggregation and stemness enhancement in human mesenchymal stem cells by testing the hypothesis that cellular events induced during 3D aggregation on non-adherent substratum induces changes in mitochondrial metabolism that promote the expression of stem cell genes Oct4, Sox2, and Nanog. [Stem Cells] Abstract | Full Article Researchers evaluated the potential differentiation ability of gingiva originated human mesenchymal stem cells in the presence of tacrolimus. [Sci Rep] Full Article Investigators aimed to analyze how the mutation of Tks4 affects the differentiation potential of multipotent bone marrow MSCs. [Sci Rep] Full Article Impact of Polo-Like Kinase 1 Inhibitors on Human Adipose Tissue-Derived Mesenchymal Stem Cells Scientists showed that both visceral and subcutaneous adipose tissue-derived mesenchymal stem cells display monopolar spindles, reduced viability and strong apoptosis induction upon treatment with BI 2536 and BI 6727, the Plk1 kinase domain inhibitors, and with Poloxin, the regulatory Polo-box domain inhibitor. [Oncotarget] Full Article IN VIVOScientists examined the effectiveness of hypoxia preconditioning for enhancing the bioactivity and tissue-regenerative potential of adipose-derived mesenchymal stem cells (MSCs). Hypoxia preconditioning enhanced the proliferative potential of MSCs by promoting the expression of normal cellular prion protein. [Cell Death Dis] Full Article Mesenchymal stem cells derived from human umbilical cord tissue, termed UCX®, have the potential to promote a full range of events leading to tissue regeneration and homeostasis. Scientists investigated UCX® action in experimentally induced hindlimb ischemia. [Stem Cell Res Ther] Full Article DNA N6-Methyladenine Demethylase ALKBH1 Enhances Osteogenic Differentiation of Human MSCs The authors demonstrated that the expression of ALKBH1 in human mesenchymal stem cells (MSCs) was upregulated during osteogenic induction. Knockdown of ALKBH1 increased the genomic DNA N6-methyladenine levels and significantly reduced the expression of osteogenic-related genes, alkaline phosphatase activity, and mineralization. [Bone Res] Full Article The current study demonstrated that systemic administration of allogenic mesenchymal stem cells (MSCs) had no obvious effect on osteoporotic bone loss in ovariectomized (OVX) rats when using the cells from the same donor; and repeated injection of allogeneic MSCs from different donors might promote bone loss in OVX rats. [PLoS One] Full Article | |
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REVIEWSThe Role of Autophagy in the Maintenance of Stemness and Differentiation of Mesenchymal Stem Cells The authors review the current literature on the complex liaison between autophagy induced by various extra- or intracellular stimuli and the molecular targets that affect mesenchymal stem cells proliferation and differentiation. [Stem Cell Rev] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSPall Corporation announced the signing of a commercial collaboration agreement with RoosterBio Inc. The agreement will encompass a co-development and marketing partnership, delivering complete solutions for industrial-scale bioreactor expansion of human mesenchymal stem/stromal cells. [Pall Corporation] Press Release Six Researchers at UC San Diego Receive $5 Million from NIH for Transformative Research Four biologists, a nanoengineer and a biophysicist at UC San Diego received a total of more than $5 million in grants from the National Institutes of Health to pursue innovative and transformative research projects. [UC San Diego] Press Release | |
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POLICY NEWSA recruitment and retention program launched by the Howard Hughes Medical Institution in Chevy Chase, Maryland, aims to reduce barriers for women and under-represented minorities who seek academic-research careers in the life sciences. [Nature Careers] Editorial Investors Flee as Firm Scraps RNA-Interference Drug Candidate A prominent developer of drugs that use RNA interference has abandoned one of its leading candidates amid safety concerns — sending a fresh wave of worry through a field that has long struggled to bring treatments to market. [Nature News] Editorial The Many Shades of European Postdoc Funding Finding the right grant or fellowship to fund a postdoc can be a challenge, and the situation is all the more complex in Europe, where academic systems, career prospects, and living costs vary widely among countries. [Science Careers] Editorial
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EVENTSNEW Stem Cells and Regenerative Medicine 2nd International Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowship(s) – Multiple Laboratories (Cleveland Clinic Lerner Research Institute) Research Associate – Mesenchymal (STEMCELL Technologies, Inc.) Postdoctoral Position – Gene Therapy (UC Davis) Faculty Position – Pluripotent Stem Cell Research (Stanford University) Research Group Leader Position – Mesenchymal Cancer Biology (Oslo University Hospital) Postdoctoral Fellow – Role of Stromal Mesenchymal Cells in Tissue Injury/Repair (Institut Pasteur) Faculty Positions – Various Areas (Jackson Laboratory) Postdoctoral Fellow/Scientist – Osteoblast Biology (Michigan State University) Postdoctoral Position – Bone and Stem Cell Research (University of Connecticut Health) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Mesenchymal Cell News Volume 8.40 | Oct 11 2016
