Mesenchymal Cell News Volume 8.46 | Nov 22 2016

TOP STORY

Randomized Comparison of Allogeneic vs. Autologous Mesenchymal Stem Cells for Non-Lschemic Dilated Cardiomyopathy: POSEIDON-DCM Trial

While human mesenchymal stem cells have been tested in ischemic cardiomyopathy, few studies exist in chronic non-ischemic dilated cardiomyopathy (NIDCM).The POSEIDON-DCM trial is a randomized comparison of safety and efficacy of autologous vs. allogeneic bone marrow-derived human mesenchymal stem cells in NIDCM. [J Am Coll Cardiol] Full Article | Press Release

(Ranked by impact factor of the journal)

IN VITRO

Adipose Snail1 Regulates Lipolysis and Lipid Partitioning by Suppressing Adipose Triacylglycerol Lipase Expression

The authors have identified a Snail1-adipose triacylglycerol lipase axis that regulates adipose lipolysis and fatty acid release, thereby governing lipid partitioning between adipose and non-adipose tissues. [Cell Rep] Full Article | Graphical Abstract

Mesenchymal Stem Cell-Derived Microvesicles Modulate LPS-Induced Inflammatory Responses to Microglia Cells

Investigators demonstrated that the presence of mesenchymal stromal cells microvesicles prevents Tumor necrosis factor-α, Interleukin-1β and IL-6 upregulation by BV-2 cells and primary microglia cells towards lipopolysaccharides (LPS). [Stem Cells] Abstract

Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis

Investigators found gene expression profiles of mesenchymal stromal cells from idiopathic pulmonary fibrosis subjects with progressive disease were enriched for genes regulating lung development. Most notably, genes regulating early tissue patterning and branching morphogenesis were differentially regulated. [Sci Rep] Full Article

Effects of Light-Emitting Diode Irradiation on the Osteogenesis of Human Umbilical Cord Mesenchymal Stem Cells In Vitro

Scientists examined the effects of light-emitting diode photobiomodulation therapy on the proliferation and differentiation of human umbilical cord mesenchymal stem cells cultured in osteogenic differentiation medium. [Sci Rep] Full Article

Defined Three-Dimensional Culture Conditions Mediate Efficient Induction of Definitive Endoderm Lineage from Human Umbilical Cord Wharton’s Jelly Mesenchymal Stem Cells

The authors present a defined 3D differentiation protocol of Wharton’s jelly-derived mesenchymal stem cells into definitive endoderm cells. [Stem Cell Res Ther] Full Article

Mesenchymal Stem Cells Attenuate the Adverse Effects of Immunosuppressive Drugs on Distinct T Cell Subopulations

Researchers investigated the effects of immunosuppressants on individual T cell subpopulations and the efficacy of mesenchymal stem cells-based treatment combined with immunosuppressive drugs. [Stem Cell Rev] Abstract

Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion

The authors determined the effects of mesenchymal stromal cells (MSC) on Osteosarcoma (OS) stemness and migration, two major features associated with recurrence and chemoresistance. The presence of stromal cells enhanced the number of floating spheres enriched in cancer stem cells of the OS cell population. Furthermore, the co-culturing with MSC stimulated the migratory capacity of OS via TGFβ1 and IL-6 secretion, and the neutralizing antibody anti-IL-6 impaired this effect. [PLoS One] Full Article

IN VIVO

Intravenous Allogeneic Mesenchymal Stem Cells for Non-Ischemic Cardiomyopathy: Safety and Efficacy Results of a Phase II-A Randomized Trial

Researchers assessed the safety and preliminary efficacy of intravenously administered ischemia tolerant mesenchymal stem cells in patients with non-ischemic cardiomyopathy. [Circ Res] Abstract

Cryopreserved, Xeno-Free Human Umbilical Cord Mesenchymal Stromal Cells Reduce Lung Injury Severity and Bacterial Burden in Rodent Escherichia coli-Induced Acute Respiratory Distress Syndrome

Researchers sought to compare mesenchymal stem/stromal cells from human umbilical cord, grown in xeno-free conditions, with mesenchymal stem/stromal cells from human bone marrow, in a rat model of Escherichia coli pneumonia. In addition, they determined the potential for umbilical cord-mesenchymal stem/stromal cells to reduce E. coli-induced oxidant injury. [Crit Care Med] Abstract

A Reproducible Method for the Isolation and Expansion of Ovine Mesenchymal Stromal Cells from Bone Marrow for Use in Regenerative Medicine Preclinical Studies

Scientists described a method for isolation and expansion of fibroblastic-like, adherent ovine mesenchymal stromal cells (MSCs) that express CD44, CD90, CD140a, CD105 and CD166, and display trilineage differentiation potential. The osteogenic potential of MSCs derived following this methodology was further evaluated in vivo in a translational model of osteonecrosis of the femoral head, in which the persistence of grafted cells in the host tissue and their lineage commitment into osteoblasts and osteocytes was demonstrated by tracking enhanced green fluorescent protein-labelled cells. [J Tissue Eng Regen Med] Abstract

Roles of Notch Signaling in Adipocyte Progenitor Cells and Mature Adipocytes

The authors review and discuss the roles of Notch1 signaling in adipogenesis in vitro as well as in beige adipocytes formation, adipocytes dedifferentiation and function in vivo. [J Cell Physiol] Abstract

Wharton’s Jelly Mesenchymal Stromal Cells as a Feeder Layer for the Ex Vivo Expansion of Hematopoietic Stem and Progenitor Cells: A Review

The authors review the rationale for using mesenchymal stromal cells (MSCs), particularly Wharton’s Jelly-MSCs, as a feeder layer for umbilical cord blood-hematopoietic stem and progenitor cells ex vivo expansion. In addition, they report the main findings attesting the use of these MSCs as a support in hematopoiesis. [Stem Cell Rev] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

InGeneron Announces Presentation of Results from Investigator Initiated Case Series of Its Regenerative Cell Therapy in Chronic Back Pain at IFATS

InGeneron, Inc. announced the presentation of initial data from an investigator initiated case series using its proprietary adipose-derived regenerative cell technology for the treatment of facet joint syndrome, one of the major causes of chronic back pain. [Press release from InGeneron, Inc. discussing research presented at 14^th Annual International Federation for Adipose Therapeutics and Science meeting (IFATS), San Diego] Press Release

Positive Early Data from BioTime’s Renevia Pivotal Trial Presented at IFATS Meeting

BioTime, Inc. announced details of positive data from its Renevia^® pivotal trial. The presentation was based on data from the “run-in,” testing sample subjects to the European pivotal trial. [Press release from BioTime, Inc. discussing research presented at the 14^th Annual International Federation for Adipose Therapeutics and Science meeting (IFATS), San Diego] Press Release

$25 Million Awarded to Center for Study of Regulatory Science

The FDA is funding a collaboration between Stanford and UCSF to improve the regulatory infrastructure that helps to shape modern biomedical research. [Stanford Medicine] Press Release

Salk Institute Awarded $25 Million Grant from Helmsley Charitable Trust

The Salk Institute for Biological Studies has received a $25 million grant—a renewal of the largest research gift in the Institute’s 56-year history—that will be used to continue exploring an ambitious range of projects aimed at understanding the role chronic inflammation plays in driving human disease. [Salk Institute for Biological Studies] Press Release

Center for Regenerative Medicine Receives Three Prestigious NIH Awards To Further Stem Cell Research

The Center for Regenerative Medicine at Boston Medical Center and Boston University School of Medicine has received three prestigious awards from the National Institutes of Health (NIH) to further its commitment to induced pluripotent stem cell research and education. [Boston University School of Medicine] Press Release

Immigrant and Minority Scientists Shaken by Trump Win

Scientists are reconsidering whether to work or study in the United States. Worries include job prospects, discrimination — and safety. [Nature News] Editorial

Peer-Review ‘Heroes’ Do Lion’s Share of the Work

In 2015, the number of scientists in the life sciences far exceeded the demand on them for peer review, according to Michail Kovanis, a computational physicist at the French National Institute of Health and Medical Research in Paris, and his colleagues. Yet their study also suggests – based on data obtained from a rapidly-growing website of peer-review activity – that 20% of the scientists undertook between 69% and 94% of reviews last year, lending credence to some researchers’ complaints that they are overburdened. “These ‘peer-review heroes’ may be overworked, with risk of downgraded peer-review standards,” Kovanis and colleagues write in a paper published in PLOS One [Nature News] Editorial

Cautious Welcome for UK’s Vague £2 Billion Research Pledge

UK scientists have welcomed a surprise government promise to invest an extra £2 billion (US$2.5 billion) per year into research and development by 2020 – although details of the pledge will not be made clear for at least another two days. [Nature News] Editorial

Conservatives, Liberals Team Up against Animal Research

“Painful, bizarre, and wasteful experiments.” Buying dogs “just to cut them apart … and kill them.” These statements might sound like the rhetoric used by extreme animal rights groups, but they come from White Coat Waste—a new, unlikely coalition of fiscal conservatives and liberal activists that aims to end federal funding for research involving dogs and other animals by targeting people’s pocketbooks in addition to their heartstrings. [ScienceInsider] Editorial

NEW Regenerative Medicine Workshop at Hilton Head
March 1-4, 2017
Atlanta, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellowship – Aging and Regeneration (University of California San Francisco)

Research Associate – Mesenchymal (STEMCELL Technologies, Inc.)

PhD Position – Cartilage to Bone Transitions (IRCCS)

Scientist – Upstream Process Development-Mesenchymal Stem Cell (Codiak BioSciences)

Postdoctoral Fellows – Mesenchymal Stem Cells (Texas A&M; Health Science Center)

Professor – Cancer Biology (University of Pennsylvania)

The MRC Weatherall Institute of Molecular Medicine – PhD Studentships (The Weatherall Institute of Molecular Medicine)

Mesenchymal Stromal/Stem Cell Scientist (UHN Arthritis Program)

Postdoctoral Fellow – Stem Cells & Cartilage Development/Disease (Boston Children’s Hospital and Harvard Medical School)

Staff Scientist/Research Assistant II – Musculoskeletal Tissue Development (Boston Children’s Hospital and Harvard Medical School)

Postdoctoral Fellow – Role of Stromal Mesenchymal Cells in Tissue Injury/Repair (Institut Pasteur)

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