Mesenchymal Cell News Volume 16.05 | Feb 13 2024

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    2024-02-13 | MESCN 16.05


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.18 – 13 February, 2024
    TOP STORY

    Neoteric Semiembedded β-Tricalcium Phosphate Promotes Osteogenic Differentiation of Mesenchymal Stem Cells under Cyclic Stretch

    A novel semiembedded technique was utilized to anchor β-TCP nanoparticles onto the surface of the elastic polymer, followed by hydrophilic modification with the polymerization of dopamine.
    [ACS Applied Materials & Interfaces]

    AbstractGraphical Abstract
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    Mesenchymal Stem Cell-Derived Extracellular Vesicles Exert Pro-Angiogenic and Pro-Lymphangiogenic Effects in Ischemic Tissues by Transferring Various microRNAs and Proteins Including ITGa5 and NRP1

    Scientists analyzed biological effects of bone marrow MSC-extracellular vesicles on endothelial cells in ischemic tissues both in in vitro and in vivo conditions and elucidated the molecular mechanisms underlying the tissue repair.
    [Journal Of Nanobiotechnology]

    Full Article

    Unravelling microRNA Regulation and miRNA–mRNA Regulatory Networks in Osteogenesis Driven by 3D Nanotopographical Cues

    Researchers profiled genes and microRNAs via next-generation sequencing in human MSCs driven toward osteogenesis via architectural cues in 3D matrices and compared with cells in 2D culture driven toward osteogenesis via soluble osteoinductive factors.
    [Biomaterials Science]

    AbstractGraphical Abstract

    3D Bio Scaffold Support Osteogenic Differentiation of Mesenchymal Stem Cells

    A hydrogel prepared from decellularized human umbilical cord tissue was developed and evaluated for osteochondral regeneration. MSCs isolated from the umbilical cord were seeded with hydrogel for 28 days, and cell-hydrogel composites were cultured in basal and osteogenic media.
    [Cell Biology International]

    Abstract

    Endometrial Mesenchymal Stromal/Stem Cells Improve Regeneration of Injured Endometrium in Mice

    Electrocoagulation was applied to the left uterine horn of NOD/SCID mice causing endometrial injury. Human endometrial MSCs or phosphate-buffered saline was then injected into the left injured horn while the right normal horn served as controls.
    [Biological Research]

    Full Article

    Suppression of MALAT1 Promotes Human Synovial Mesenchymal Stem Cells Enhance Chondrogenic Differentiation and Prevent Osteoarthritis of the Knee in a Rat Model via Regulating miR-212-5p/MyD88 Axis

    To determine whether or not human MSCs isolated from the human synovial membrane might differentiate, researchers used a number of different culture settings and labeling techniques.
    [Cell And Tissue Research]

    Abstract

    Chitosan Hydrogel Dressing Loaded with Adipose Mesenchymal Stem Cell-Derived Exosomes Promotes Skin Full-Thickness Wound Repair

    A composite wound dressing consisting of the chitosan hydrogel and adipose MSC-derived exosome was designed and fabricated by a physical mixing method to promote the skin full-thickness wound repair.
    [ACS Applied Bio Materials]

    AbstractGraphical Abstract

    Mesenchymal Stem Cells Enhance Targeted Bone Growth from Injectable Hydrogels with BMP-2 Peptides

    MSC-laden DWIVA peptide-functionalized hydrogels presented rapidly induce targeted bone formation and have the potential to form nascent bone within bones in jeopardy of an osteoporotic fracture such as the femur.
    [Journal Of Orthopaedic Research]

    Full Article

    Icariin Promotes Bone Marrow Mesenchymal Stem Cells Osteogenic Differentiation via the mTOR/Autophagy Pathway to Improve Ketogenic Diet-Associated Osteoporosis

    Thirty mice were divided into: sham, ketogenic diet (KD), and KD + icariin groups. Post a 12-week intervention, evaluations including bone microstructures, serum concentrations of tartrate-resistant acid phosphatase and bone-specific alkaline phosphatase were carried out.
    [Journal Of Orthopaedic Surgery And Research]

    Full Article
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    REVIEWS

    Enhancing Osteoporosis Treatment with Engineered Mesenchymal Stem Cell-Derived Extracellular Vesicles: Mechanisms and Advances

    The authors review advancements in utilizing MSCs and their derived extracellular vesicles for osteoporosis treatment.
    [Cell Death & Disease]

    Full Article

    Mesenchymal Stem Cell-Derived Exosomes: A Promising Alternative in the Therapy of Preeclampsia

    Scientistss elaborate on the potential therapeutic mechanism of MSC-exosomes (Exos) in treating preeclampsia, considering the main pathogenic factors of the condition, including placental vascular dysplasia, immunological disorders, and oxidative stress, based on the biological function of MSC-Exos.
    [Stem Cell Research & Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Biomedical Researcher Seeks to Improve Outcomes in Stem Cell Treatments

    Rebekah Samsonraj, an assistant professor of biomedical engineering, has made the study of stem cells her life’s work, and her latest goal is to improve the quality of mesenchymal stem cells (MSCs) biomanufactured for medical treatments, particularly in regenerative medicine.
    [University of Arkansas]

    Press Release

    The Untapped Potential of Stem Cells in Menstrual Blood

    Roughly 20 years ago, a biologist named Caroline Gargett went in search of some remarkable cells in tissue that had been removed during hysterectomy surgeries. The cells came from the endometrium, which lines the inside of the uterus.
    [VaccinesWork]

    Press Release
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    JOB OPPORTUNITIES

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    Case Western Reserve University – Cleveland, Ohio, United States

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    Boston University – Boston, Massachusetts, United States

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