Muscle Cell News 1.11 May 30, 2016 | |
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TOP STORYAsymmetric Division of Clonal Muscle Stem Cells Coordinates Muscle Regeneration In Vivo Researchers define a zebrafish muscle stem cell population analogous to the mammalian satellite cell and image the entire process of muscle regeneration from injury to fiber replacement in vivo. [Science] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSPostnatal Telomere Dysfunction Induces Cardiomyocyte Cell-Cycle Arrest through p21 Activation Scientists showed that telomerase activity and cardiomyocyte telomere length decrease sharply in wild-type mouse hearts after birth, resulting in cardiomyocytes with dysfunctional telomeres and anaphase bridges and positive for the cell-cycle arrest protein p21. [J Cell Biol] Abstract | Press Release Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes Investigators showed that the RNA-binding protein RBFOX2 contributes to transcriptome changes under diabetic conditions. RBFOX2 controls alternative splicing of genes with important roles in heart function relevant to diabetic cardiomyopathy. [Cell Rep] Full Article | Graphical Abstract | Press Release Investigators isolated and characterized mouse and human mesenchymal stem cells (MSCs) and knocked down class II transactivator (CIITA) expression. Wild-type or CIITA-knockout mouse MSCs were implanted into infarcted mouse myocardia, and recipient allo-antibody formation, cell survival, and cardiac function were measured. [FASEB J] Abstract Scientists investigated the role of microRNAs in regulating p53-p21 pathway in high glucose (HG)-induced cardiomyocyte hypertrophy and apoptosis. Cardiac expression of microRNAs was measured in diabetic patients, diabetic rats, and in HG-treated cardiomyocytes. [Mol Cell Biochem] Abstract SKELETAL MUSCLE CELLSResearchers uncovered at the heart of this response a signaling module encompassing NOTCH, GSK-3βSNAI1 and β-catenin. Independent of its transcriptional function, NOTCH profoundly inhibits GSK-3βactivity. [Elife] Abstract | Download Full Article Scientists present a human Duchenne muscular dystrophy model using human induced pluripotent stem cells (iPSCs). Their model revealed concordant disease-related phenotypes with patient-dependent variation, which are partially reversed by genetic and pharmacological approaches. [Cell Rep] Full Article | Graphical Abstract | Press Release Investigators developed a scalable monolayer system to differentiate human embryonic stem cells into mature skeletal muscle cells within 26 days, without cell sorting or genetic manipulation. [Stem Cells Transl Med] Abstract | Press Release Low Six4 and Six5 Gene Dosage Improves Dystrophic Phenotype and Prolongs Life Span of mdx Mice To investigate SIX4 and SIX5 functions during muscle regeneration, investigators introduced knockout alleles of Six4 and Six5 into an animal model of Duchenne muscular dystrophy, mdx mice, characterized by frequent degeneration-regeneration cycles in muscles. [Dev Growth Differ] Abstract SMOOTH MUSCLE CELLSMethyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation In Vitro and In Vivo The authors investigated the ability and molecular mechanisms of methyl protodioscin, a steroidal saponin isolated from the root of Dioscorea nipponica, to inhibit neointimal formation. They demonstrated that methyl protodioscin markedly inhibited the growth and migration of vascular smooth muscle cells (A7r5 cells). [J Nat Prod] Abstract Researchers investigated the alteration of voltage-dependent K+ channels in mesenteric arterial smooth muscle cells from control and diabetic rats during the early and chronic phases of diabetes. [Clin Exp Pharmacol Physiol] Abstract | |
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REVIEWSGene Transfer to Promote Cardiac Regeneration Leading from the large quantity of new information gathered over the last few years on the mechanisms controlling cardiomyocyte proliferation during embryonic and fetal life, it is now possible to devise innovative therapies based on cardiac gene transfer. [Crit Rev Clin Lab Sci] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field.
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INDUSTRY NEWSNSF Grant Will Help Decipher Cells’ Electric Properties A Michigan State University researcher will use a National Science Foundation grant to decipher the secrets of electric organs in fish and apply the insights to human electrically excitable tissue. [Michigan State University] Press Release Regen BioPharma, Inc. Announces ucVax: Universal Donor Cancer Cellular Immunotherapy Regen BioPharma, Inc. and announced initiation of a preclinical development program aimed at creating the first cord blood based cancer immunotherapeutic product leveraging its NR2F6 immunological checkpoint. [Regen BioPharma, Inc. (PR Newswire Association LLC.)] Press Release | |
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EVENTSNEW 2016 New Directions in Biology and Disease of Skeletal Muscle Conference Visit our events page to see a complete list of events in the muscle cell community.
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JOB OPPORTUNITIESResearch Technologist – Myogenic and Progenitor Cell (STEMCELL Technologies Inc.) Postdoctoral Fellow – Regeneration of the Mammalian Heart (UT Southwestern Medical Center) Postdoctoral Fellow – Skeletal Muscle Repair and Performance (GlaxoSmithKline) Postdoctoral Scientist – Airway Smooth Muscle Biology (UCSF) Postdoctoral Fellow – Genome Editing for Striated Muscle Regeneration (Duke University) Postdoctoral Position – Chemical and Structural Biology of RNA (The Scripps Research Institute) PhD Position – Muscle Fiber Type Switch in Congenital Myopathies (King’s College London) Postdoctoral Fellow – Pathogenesis of Heart and Vascular Injury (University of Alberta) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Muscle Cell News Volume 1.11 | May 30 2016