Muscle Cell News 1.14 June 20, 2016 | |
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TOP STORYLab-Grown Nerve Cells Make Heart Cells Throb Researchers report that a type of lab-grown human nerve cells can partner with heart muscle cells to stimulate contractions. Because the heart-thumping nerve cells were derived from induced pluripotent stem cells that in turn were made from human skin cells, the researchers believe the cells will be an aid in studying disorders that affect the nervous system. [Press release from John Hopkins Medicine discussing online prepublication in Cell Stem Cell] Press Release | Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSScientists investigated canonical Wnt/β-catenin signaling and how it regulated c-Myc expression in failing hearts of human ischemic heart disease, idiopathic dilated cardiomyopathy, and murine desmin-related cardiomyopathy. [Circ Heart Fail] Abstract Investigators tested the hypothesis that the direct effect of glucocorticoid receptor-mediated epigenetic repression of cyclin D2 gene in the cardiomyocyte plays a key role in the dexamethasone-mediated effects in the developing heart. [J Pharmacol Exp Ther] Abstract Although canstatin is known as an endogenous anti-angiogenic factor, its effects on cardiomyocytes have not been clarified. Researchers examined the effects of canstatin on isoproterenol-induced apoptosis in differentiated H9c2 cardiomyoblasts. [Apoptosis] Abstract SKELETAL MUSCLE CELLSResearchers showed that the microRNA-17-92 cluster promotes mouse myoblast proliferation but inhibits myotube formation. [Cell Death Differ] Full Article Exercise Conditioning in Old Mice Improves Skeletal Muscle Regeneration Investigators examined whether exercise is able to improve regenerative response in skeletal muscle of aged mice. 22 month-old male C57Bl/6J mice (n = 20) underwent an eight weeks progressive exercise training protocol. [FASEB J] Abstract | Press Release The Ubiquitin Ligase Tripartite-Motif-Protein 32 Is Induced in Duchenne Muscular Dystrophy Scientists sought to determine the components of the ubiquitin-proteasome pathway that are specifically activated in human dystrophin-deficient muscles. [Lab Invest] Abstract SMOOTH MUSCLE CELLSSoluble guanylate cyclase, a key enzyme of the nitric oxide signaling pathway, is formed as a heterodimer by various isoforms of its α and β subunit. GUCY1A3, encoding the α1 subunit, was identified as a risk gene for coronary artery disease and myocardial infarction, but its specific contribution to atherosclerosis remains unclear. Investigators sought to decipher the role of Gucy1a3 in atherosclerosis in mice. [Am J Pathol] Full Article miRNA-34a Promotes Proliferation of Human Pulmonary Artery Smooth Muscle Cells by Targeting PDGFRA miR-34 family expression was evaluated in a rat model with hypoxia and in cultured hypoxic pulmonary artery smooth muscle cells, using real-time quantitative PCR. [Cell Prolif] Abstract Researchers found that polymeric IgA-treated human mesangial cells exhibited higher NF-κB activity as reflected by the increased levels of nuclear p65. [Am J Nephrol] Abstract | |
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REVIEWSTargeting Muscle Stem Cell Intrinsic Defects to Treat Duchenne Muscular Dystrophy The authors discuss how new findings affect regenerative therapies for muscular dystrophies. Therapies targeting satellite cells hold great potential and could have long-term efficiency owing to the high self-renewal ability of these cells. [npj Regen Med] Full Article Visit our reviews page to see a complete list of reviews in the muscle cell research field.
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SCIENCE NEWSCapricor Therapeutics Reports Positive 12-Month Data from the DYNAMIC Clinical Trial Capricor Therapeutics, Inc. announced positive preliminary 12-month data from its DYNAMIC clinical trial, which evaluated CAP-1002 in patients with advanced heart failure. [Capricor Therapeutics, Inc.] Press Release | |
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INDUSTRY NEWSTiGenix Announces Six-Month Phase I/II Results of AlloCSC-01 in Acute Myocardial Infarction TiGenix NV announced preliminary six-month results from the CAREMI clinical trial, an exploratory Phase I/II study of AlloCSC-01, TiGenix’s expanded cardiac stem cell treatment for acute myocardial infarction. [TiGenix NV (GlobeNewswire Inc.)] Press Release Lenox Hill Hospital researchers are taking part in a national trial investigating whether damaged heart tissue can be safely and effectively regenerated with the help of adult cardiac stem cells. [Northwell Health] Press Release Mesoblast Provides Update on Global Heart Failure Program Mesoblast Limited announced that it has regained full worldwide rights and full strategic flexibility to exploit its mesenchymal precursor cell technology platform for the cardiovascular field. [Mesoblast Limited (GlobeNewswire, Inc.)] Press Release
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EVENTSNEW ICCSCE 2016: 18th International Conference on Cell and Stem Cell Engineering Visit our events page to see a complete list of events in the muscle cell community.
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JOB OPPORTUNITIESNEW Post-Doc/Associate Specialist – Autophagy (Nestlé Institute of Health Sciences) NEW Postdoctoral Fellow – Skeletal Muscle Biology (University of Michigan) Research Technologist – Myogenic and Progenitor Cell (STEMCELL Technologies Inc.) PhD Position – Phosphoinositides and Related Proteins Mutated in Myopathies (CERBM) Post-Doctoral Researcher – Biophysics of Cytoskeletal Motors (Pennsylvania Muscle Institute) Associate Professor/Professor – Cardiovascular Research (Monash University) Postdoctoral Fellow – Regeneration of the Mammalian Heart (UT Southwestern Medical Center) Postdoctoral Fellow – Skeletal Muscle Repair and Performance (GlaxoSmithKline) Postdoctoral Scientist – Airway Smooth Muscle Biology (UCSF) Postdoctoral Fellow – Genome Editing for Striated Muscle Regeneration (Duke University) PhD Position – Muscle Fiber Type Switch in Congenital Myopathies (King’s College London) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Muscle Cell News Volume 1.14 | Jun 20 2016