Muscle Cell News 1.15 June 27, 2016 | |
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TOP STORYHyperamylinemia Increases IL-1β Synthesis in the Heart via Peroxidative Sarcolemmal Injury To determine the impact of hyperamylinemia on cardiac myocytes, researchers investigated human myocardium, compared diabetic HIP rats with diabetic rats expressing endogenous (non-amyloidogenic) rat amylin, studied normal mice injected with aggregated human amylin and developed in vitro cell models. [Diabetes] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSScientists investigated the cardiac progenitor cell (CPC)-derived exosomal microRNA on protecting myocardium under oxidative stress. Sca1+CPCs-derived exosomes were purified from conditional medium, and identified by nanoparticle trafficking analysis, transmission electron microscopy and western blotting using CD63, CD9 and Alix as markers. [Cell Death Dis] Full Article Using a post-myocardial infarction model of heart failure (HF) in mice, researchers applied microarray assay to examine the transcriptome of circular RNAs deregulated in the heart during HF. [Cell Physiol Biochem] Full Article SKELETAL MUSCLE CELLSSatellite cells (SCs) from type 1 diabetes rodent and human samples were examined to discern differences in SC density and functionality compared to their respective controls. [Diabetes] Abstract CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion Researchers found that cellular repressor of E1A-stimulated genes 1 (CREG1) is highly expressed in both embryonic and adult hearts. Gain- and loss-of-function analyses demonstrated that CREG1 is required for differentiation of mouse embryonic stem cell into cardiomyocytes and the formation of cohesive myocardium-like structures in a cell autonomous fashion. [Stem Cells] Abstract Postexercise High-Fat Feeding Suppresses p70S6K1 Activity in Human Skeletal Muscle Scientists examined the effects of reduced CHO but high post-exercise fat availability on cell signaling and expression of genes with putative roles in regulation of mitochondrial biogenesis, lipid metabolism and muscle protein synthesis. [Med Sci Sports Exerc] Abstract Investigators examined whether muscle IL-6 contributes to exercise-induced pyruvate dehydrogenase regulation in skeletal muscle. [PLoS One] Full Article Scientists suggest that SIRT3 does not appear to be regulated by changes in mitochondrial localization at the time points measured in the current study in response to cellular energy stress in human skeletal muscle. [Exp Physiol] Abstract | Press Release SMOOTH MUSCLE CELLSGata3 Hypomorphic Mutant Mice Rescued with a YAC Transgene Suffer a Glomerular Mesangial Cell Defect Scientists demonstrated that GATA3 is specifically expressed in glomerular mesangial cells and plays a critical role in the maintenance of renal glomerular function. [Mol Cell Biol] Abstract Investigators analyzed bindarit effects on ET1-, AngII- and TGFβ-induced mesangial cell dysfunction. Bindarit significantly reduced AngII-, ET1- and TGFβ-induced α-smooth muscle actin upregulation. [Cytokine] Abstract Scientists investigated the effect of eosinophils from asthmatic and non-asthmatic subjects on Wnt-5a, transforming growth factor β1 (TGF-β1), and extracellular matrix protein (fibronectin and collagen) gene expression and airway smooth muscle cells proliferation. [BMC Pulm Med] Full Article | |
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REVIEWSNovel Therapeutic Strategies Targeting Fibroblasts and Fibrosis in Heart Disease The authors outline the origins and roles of fibroblasts in cardiac development, homeostasis and disease; illustrates the involvement of fibroblasts in current and emerging clinical interventions; and identifies future targets for research and development. [Nat Rev Drug Discov] Abstract | Press Release Successful restoration of functional innervation during muscle repair is essential; the authors emphasize the integrative role of satellite-cell biology in the progressive coordination of adaptive cellular and tissue responses during the injury-repair process in voluntary muscle. [Biol Rev Camb Philos Soc] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSSanthera Pharmaceuticals announced that the European Medicines Agency has validated its Marketing Authorization Application for Raxone® for DMD in patients with respiratory function decline who are not taking concomitant glucocorticoids. [Santhera Pharmaceuticals] Press Release PPMD Awards The Ohio State University Grant to Support Cardiomyopathy Therapy for Duchenne Parent Project Muscular Dystrophy (PPMD) announced plans to award Dr. Denis Guttridge of The Ohio State University with a $48,000 grant for his work in cardiac issues in Duchenne. [Parent Project Muscular Dystrophy] Press Release | |
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POLICY NEWSResearchers Reeling as UK Votes to Leave EU The United Kingdom’s vote to leave the European Union has plunged it into political and economic uncertainty — and left researchers worried over the future of their funding and collaborations, the UK’s participation in major European research programs, and the freedom of movement and employment status of thousands of scientists. [Nature News] Editorial
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EVENTSNEW Stem Cell Society Singapore (SCSS) Symposium 2016 NEW From Stem Cells to Human Development Visit our events page to see a complete list of events in the muscle cell community.
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JOB OPPORTUNITIESNEW Postdoctoral Positions – Skeletal Muscle Stem Cells and Molecular Medicine (UPEC) Research Technologist – Myogenic and Progenitor Cell (STEMCELL Technologies Inc.) Post-Doc/Associate Specialist – Autophagy (Nestlé Institute of Health Sciences) Postdoctoral Fellow – Skeletal Muscle Biology (University of Michigan) PhD Position – Phosphoinositides and Related Proteins Mutated in Myopathies (CERBM) Post-Doctoral Researcher – Biophysics of Cytoskeletal Motors (Pennsylvania Muscle Institute) Associate Professor/Professor – Cardiovascular Research (Monash University) Postdoctoral Fellow – Regeneration of the Mammalian Heart (UT Southwestern Medical Center) Postdoctoral Fellow – Skeletal Muscle Repair and Performance (GlaxoSmithKline) Postdoctoral Scientist – Airway Smooth Muscle Biology (UCSF) PhD Position – Muscle Fiber Type Switch in Congenital Myopathies (King’s College London) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Muscle Cell News Volume 1.15 | Jun 27 2016