Muscle Cell News 1.18 July 18, 2016 | |
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TOP STORYSignal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA Investigators described a signal-dependent mechanism for the regulation of BRD4 in cardiomyocytes. BRD4 expression was suppressed by microRNA-9, which targeted the 3′ UTR of the Brd4 transcript. [Cell Rep] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSFAK Forms a Complex with MEF2 to Couple Biomechanical Signaling to Transcription in Cardiomyocytes Investigators showed that focal adhesion kinase (FAK) interacts with and regulates myocyte enhancer factor 2 (MEF2), a master cardiac transcriptional regulator. [Structure] Abstract | Graphical Abstract Unsupervised co-expression network analysis of transcriptomic profiles identified discrete modules of co-expressed genes associated with the degree of muscle weakness and atrophy in early and sustained ICU acquired weakness. Modules were enriched for genes involved in skeletal muscle regeneration and extracellular matrix deposition. [Sci Rep] Full Article SKELETAL MUSCLE CELLSDnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2 Researchers investigated the consequences of mutating Dnmt3a in muscle precursor cells in mice. Pax3 promoter-driven Dnmt3a-conditional knockout mice exhibit decreased organ mass in the skeletal muscles, and attenuated regeneration after cardiotoxin-induced muscle injury. [PLoS Genet] Full Article Generation and Evaluation of Myostatin Knock-Out Rabbits and Goats Using CRISPR/Cas9 System The authors efficiently generated 24 Myostatin (Mstn) knock-out (KO) rabbits out of 32 newborn infants after embryo injection with two sgRNAs targeting rabbit Mstn, and found that the Mstn KO rabbits exhibited increased birthweight and a significant increase in the weight ratios of the quadriceps and biceps muscles to the whole body. [Sci Rep] Full Article SMOOTH MUSCLE CELLSTissue-Engineered Vascular Rings from Human iPSC-Derived Smooth Muscle Cells Scientists derived a large quantity of highly enriched functional vascular smooth muscle cells from human induced pluripotent stem cells. [Cell Rep] Full Article | Graphical Abstract Atrogin-1 Increases Smooth Muscle Contractility through Myocardin Degradation The authors showed that overexpression of atrogin-1 increased contractility of cultured smooth muscle cells and mouse aortic tissues in organ culture. [J Cell Physiol] Abstract Scientists explored the role of myoendothelial gap junctions in phenotypic switching of human coronary artery smooth muscle cells co-cultured with human coronary artery endothelial cells exposed to shear stress. [Cell Physiol Biochem] Abstract Investigators evaluated the role of K+ channel 2.1 (Kir2.1) on vascular smooth muscle cell proliferation, migration, phenotype switching, and post-injury carotid neointimal formation. [Biochem Biophys Res Commun] Abstract | |
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REVIEWSThe Role of AMPK in Cardiomyocyte Health and Survival The authors discuss the important role that adenosine monophosphate-activated protein kinase (AMPK) plays in regulating cardiac metabolism, as well as the additional cellular processes that may contribute to cardiomyocyte function and survival in the healthy and the diseased heart. [Biochim Biophys Acta] Abstract Cardiac Progenitor Cells for Heart Repair This review outlines current research into cardiac progenitor cell populations and their cardiac repair/regenerative potential. [Cell Death Disc] Full Article Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSRoivant Sciences Ltd. and Plexcera Therapeutics LLC announced the formation of Enzyvant Sciences Ltd., a new biopharmaceutical company focused on the development of recombinant human acid ceramidase, an enzyme replacement therapy for the treatment of patients with Farber disease. [Roivant Sciences Ltd.] Press Release Santhera Pharmaceuticals announced that it has received written correspondence from the U.S. Food and Drug Administration on its proposed subpart H approval pathway for Raxone in DMD patients not taking concomitant glucocorticoids. [Santhera Pharmaceuticals] Press Release | |
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POLICY NEWSPolicy: Five Cornerstones of a Global Bioeconomy Bioscience leaders such as the European Union, Japan and the United States see expanding the bioeconomy as a means of reindustrializing and creating wealth. Emerging industrial economies such as China and India see biotechnology as a nascent field of innovation in which they can quickly compete. Brazil, South Africa and Malaysia are investing to add value to their vast biological resources. [Nature News] Editorial After Protest, Canada’s Health Science Funder Reverses Course on Peer-Review Changes Canada’s scientific community carved a major notch in its belt by successfully forcing Canadian Institutes of Health Research President Alain Beaudet into a partial retreat from his controversial introduction of online peer review. [ScienceInsider] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) 2016 Visit our events page to see a complete list of events in the muscle cell community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Biomedical Engineering (University of South Dakota) NEW Postdoctoral Position – Duchenne Muscular Dystrophy (Leiden University Medical Center) NEW Group Leader – Cardio Pulmonary Science (Justus-Liebig-Universität Gießen) Postdoctoral Fellow – Muscle Energetics (National Institutes of Health) Postdoctoral Fellow – Skeletal Muscle Biology (University of Texas Health Science Center) Post-Doc/Associate Specialist – Autophagy (Nestlé Institute of Health Sciences) Postdoctoral Fellow – Skeletal Muscle Biology (University of Michigan) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Muscle Cell News Volume 1.18 | Jul 18 2016