Muscle Cell News 1.22 August 22, 2016 | |
| |
TOP STORYHeart Muscle Made from Stem Cells Aids Precision Cardiovascular Medicine Researchers discovered that heart muscle cells made from induced pluripotent stem cells share gene expression patterns with native donor tissue. These cells can be used to indicate people who should avoid certain medications that could damage their hearts. [Press release from Stanford University discussing online prepublication in Cell Stem Cell] Press Release | Abstract | Graphical Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSMesp1 Marked Cardiac Progenitor Cells Repair Infarcted Mouse Hearts Investigators captured EYFP+ cells that strongly expressed cardiac mesoderm markers and cardiac transcription factors, but not pluripotent or nascent mesoderm markers. [Sci Rep] Full Article Researchers analyzed the metabolomic profile of late-onset Pompe disease induced pluripotent stem cell-derived cardiomyocytes and found that oxidative stress and mitochondrial dysfunction are likely associated with cardiac complications. [Stem Cells Transl Med] Abstract Activation of HuR Downstream of p38 MAPK Promotes Cardiomyocyte Hypertrophy Investigators showed that human antigen R (HuR) undergoes cytoplasmic translocation, indicative of its activation, in hypertrophic cardiac myocytes. [Cell Signal] Abstract Scientists determined the expression of miRNA (miR)-20a, smoothened (SMO) and marker proteins of cardiomyocytes (cTnT, GATA4 and desmin) by quantitative real-time PCR and western blot assays, respectively, and found that P19 cells have differentiated into cardiomyocytes successfully at differentiation day 10, and downregulation of miR-20a and upregulation of SMO exist in myocardially differentiated P19 cells. [Biol Open] Abstract | Full Article SKELETAL MUSCLE CELLS3D Cell Printing of Functional Skeletal Muscle Constructs Using Skeletal Muscle-Derived Bioink Investigators demonstrated that 3D cell-printing of decellularized skeletal muscle extracellular matrix-based bioink facilitates the fabrication of functional skeletal muscle constructs. [Adv Healthc Mater] Abstract Gut microbiota of obese pigs influenced skeletal muscle development and the lipid metabolic profiles. [Sci Rep] Full Article The authors demonstrated the use of image-based flow cytometry and cell-trace dye to monitor satellite cells proliferation and to identify different stages of satellite cell differentiation. [Methods] Abstract SMOOTH MUSCLE CELLSMURC Deficiency in Smooth Muscle Attenuates Pulmonary Hypertension Scientists showed that hypoxia increased Murc mRNA expression in the mouse lung, and that Murc-null mice exhibited attenuation of hypoxia-induced pulmonary hypertension (PH) accompanied by reduced ROCK activity in the lung. Conditional knockout mice lacking Murc in smooth muscle resisted hypoxia-induced PH. [Nat Commun] Full Article Olfactory Receptors Modulate Physiological Processes in Human Airway Smooth Muscle Cells Investigators demonstrated that the human olfactory receptors OR1D2 and OR2AG1 are expressed at the RNA and protein levels in human airway smooth muscle cells. [Front Physiol] Full Article | |
| |
REVIEWSAging, Metabolism and Stem Cells: Spotlight on Muscle Stem Cells The authors revise exciting recent findings on why stem cells age and the consequences on tissue regeneration, with a special focus on regeneration of skeletal muscle. [Mol Cell Endocrinol] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
| |
INDUSTRY NEWSMarathon Pharmaceuticals, LLC. announced the New Drug Applications for the investigational drug deflazacort have been accepted for filing and granted Priority Review by the U.S. Food and Drug Administration (FDA). [Marathon Pharmaceuticals, LLC.] Press Release BioTime, Inc. announced the issuance of 31 new patents that are owned by or licensed to BioTime, or its family of companies. The new patents add to the over 700 issued and pending patents worldwide in the collective portfolio and further strengthen the Company and its affiliates’ IP position in the field of regenerative medicine. [BioTime, Inc.] Press Release | |
| |
POLICY NEWSMouse Microbes May Make Scientific Studies Harder to Replicate Experimenters are questioning the potential research impact of the microbiome—a term often used to refer to commensal gut bacteria, but which also includes resident viruses, fungi, protozoa, and single-celled archaea species. [Science] Editorial US Personalized-Medicine Industry Takes Hit from Supreme Court Rejections for US patents related to personalized medicine have spiked after recent Supreme Court decisions tightened the rules for such claims, an analysis of more than 39,000 patent applications reveals. [Nature News] Editorial UK Government Gives Brexit Science Funding Guarantee British scientists say they’re relieved by a government promise to guarantee them funding for existing EU research projects, even after the country leaves the European Union. But the reassurance only partly allays concerns about Brexit’s effect on UK science. [Nature News] Editorial Spiking Genomic Databases with Misinformation Could Protect Patient Privacy Large genomic databases are indispensable for scientists looking for genetic variations associated with diseases. But they come with privacy risks for people who contribute their DNA. A 2013 study showed that hackers could use publicly available information on the Internet to identify people from their anonymized genomic data. [Nature News] Editorial
| |
EVENTSNEW 7th International Conference on Stem Cells and Cancer (ICSCC-2016): Proliferation, Differentiation and Apoptosis Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Faculty Positions – Cell and Molecular Physiology (Loyola University Chicago) NEW Faculty Positions – Genetics and Genomics (Boston University) Research Technician – Muscle Growth and Wasting (Howard Hughes Medical Institute) Research Associate – Lipid Metabolism (Wright State University, Boonshoft School of Medicine) Postdoctoral Position – Cardiovascular Stem Cell Biology (Yale University) Postdoctoral Research Fellowship – Functional Genomics and Bioinformatics (L’Institut du Thorax) Postdoctoral Position – Biomedical Engineering (University of South Dakota) Postdoctoral Position – Duchenne Muscular Dystrophy (Leiden University Medical Center) Postdoctoral Fellow – Muscle Energetics (National Institutes of Health) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Muscle Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|
Home Muscle Cell News Volume 1.22 | Aug 22 2016