Muscle Cell News 1.24 September 12, 2016 | |
| |
TOP STORYResearchers showed that Gli1+ cells located in the arterial adventitia are progenitors of vascular smooth muscle cells and contribute to neointima formation and repair after acute injury to the femoral artery. [Cell Stem Cell] Abstract | Graphical Abstract | Press Release | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSResearchers showed that telomerase-competent induced pluripotent stem cells with relatively long telomeres and high expression of the shelterin-complex protein TRF1 differentiate sooner and more efficiently into cardiomyocytes than those with relatively short telomeres and low TRF1 expression. [Stem Cells] Abstract Regulation of Myoglobin in Hypertrophied Rat Cardiomyocytes in Experimental Pulmonary Hypertension Scientists explored how cardiac hypertrophy, oxidative capacity, and myoglobin expression in right ventricular cardiomyocytes are regulated at the transcriptional and translational levels in an early stage of experimental pulmonary hypertension, in order to identify targets to improve the oxygen supply/demand ratio. [Pflugers Arch] Full Article As the effects of tumor necrosis factor-α (TNF) are specific to its two receptors (TNFRs), investigators tested the hypothesis that TNF differentially modulates cardiac stem cell function in a TNFR-specific manner. [Am J Physiol Heart Circ Physiol] Abstract Scientists revealed that lithium induced a concentration- and time-dependent rise in mitochondrial ROS formation, inhibition of respiratory complexes, mitochondrial membrane potential collapse, mitochondrial swelling, and cytochrome c release in rat heart mitochondria and also induced Caspase 3 activation through mitochondrial pathway, decline of ATP and lipid peroxidation in rat cardiomyocytes. [J Biochem Mol Toxicol] Abstract SKELETAL MUSCLE CELLSIdentification and Characterization of the Dermal Panniculus Carnosus Muscle Stem Cells Investigators analyzed Panniculus carnosus satellite cells with regard to developmental origin and purported function. Lineage tracing shows that they originate in Myf5+, Pax3/Pax7+ cell populations. [Stem Cell Reports] Full Article | Graphical Abstract Upon removal of Noggin, the number of mesenchymal Pax7+ muscle precursor cells was reduced and they were more prone to differentiate into adipocytes in vitro. [Sci Rep] Full Article SMOOTH MUSCLE CELLSMuSK Is a BMP Co-Receptor that Shapes BMP Responses and Calcium Signaling in Muscle Cells Researchers showed that muscle-specific kinase (MuSK) also promotes bone morphogenetic protein (BMP) signaling in muscle cells. MuSK bound to BMP4 and related BMPs with low nanomolar affinity in vitro and to the type I BMP receptors ALK3 and ALK6 in a ligand-independent manner both in vitro and in cultured myotubes. [Sci Signal] Abstract Scientists used CCK-8 to quantify cell proliferation after liposome-mediated transfection. Subsequently, they investigated the change in PODN and its downstream signaling proteins, including cyclin-dependent kinase 2 and p21. [Sci Rep] Full Article The authors studied early changes in pulmonary artery smooth muscle cell (PASMC) proliferation and metabolism using a unique ovine model of pulmonary over-circulation. Consistent with pulmonary arterial hypertension in adults, PASMCs derived from four-week old lambs exposed to increased pulmonary blood flow exhibited increased rates of proliferation. [Am J Physiol Heart Circ Physiol] Abstract The authors investigated myogenic constriction and vascular function of mesenteric arteries of rats chronically treated with FTY720. [PLoS One] Full Article | |
| |
REVIEWSThe authors present the idea that O2 levels regulate myogenesis and muscle regeneration, they elucidate the molecular mechanisms underlying myogenesis and muscle regeneration in hypoxia and depict therapeutic strategies using changes in O2 levels to promote muscle regeneration. [FASEB J] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
| |
INDUSTRY NEWSCapricor Therapeutics, Inc. announced that the randomized Phase I/II HOPE-Duchenne clinical trial has completed its enrollment with 25 subjects. [Capricor Therapeutics, Inc.] Press Release Parent Project Muscular Dystrophy Awards Iowa State University $200,000 Grant Parent Project Muscular Dystrophy announced plans to award Joshua Selsby, PhD of Iowa State University with a $200,000 grant to continue the study of the effects of quercetin-based therapy on dystrophic muscle. [Parent Project Muscular Dystrophy (PR Newswire Association LLC.)] Press Release | |
| |
POLICY NEWSWorkshop on Ethics of Monkey Research Earns Cheers and Boos Depending on whom you ask, the U.S. government workshop on the state of nonhuman primate research was either a raging success or a complete fiasco. The event, held at the National Institutes of Health brought together dozens of scientists, veterinarians, and bioethicists to discuss how research on monkeys and related animals is contributing to human medicine and to review the welfare policies that surround this work. [ScienceInsider] Editorial Cancer Experts Unveil Wishlist for US Government ‘Moonshot’ Advisers to the US Cancer Moonshot Initiative have produced a wide-ranging laundry list of research targets for the project — even as its funding remains uncertain. The ten recommendations released on 7 September include the launch of a national clinical-trial network specifically targeted at therapies that harness the immune system, and the creation of a 3D cancer atlas to catalogue how a tumour interacts with neighbouring normal cells. [Nature News] Editorial US Science Agencies Face Budget Limbo Another year, another round of budget roulette for US science agencies. When Congress returns from its summer break on 6 September, it will have just three weeks to pass a new government funding bill before the 2017 budget year begins on 1 October. Policy analysts predict that lawmakers will pass a stopgap funding measure that will keep agencies’ budgets flat until the presidential election in November — and perhaps into next year. [Nature News] Editorial
| |
EVENTSNEW International Conference on Stem Cell Engineering NEW International Vascular Biology Meeting NEW Cell Culture & Downstream World Congress 2017 NEW World Advanced Therapies & Regenerative Medicine Congress 2017 Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Faculty Position – Biomedical Metabolomics and Metabolism (University of Ottawa) NEW Postdoctoral Position – Lipid Metabolism (Baylor College of Medicine) NEW Project Scientist – Muscle Metabolism (University of California, Berkeley) NEW Chair – Medical Biology (Masaryk University) Faculty Positions – Cell and Molecular Physiology (Loyola University Chicago) Faculty Positions – Genetics and Genomics (Boston University) Research Technician – Muscle Growth and Wasting (Howard Hughes Medical Institute) Postdoctoral Position – Cardiovascular Stem Cell Biology (Yale University) Postdoctoral Research Fellowship – Functional Genomics and Bioinformatics (L’Institut du Thorax) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Muscle Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|