Muscle Cell News 1.28 October 17, 2016 | |
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TOP STORYAllogeneic Transplantation of iPS Cell-Derived Cardiomyocytes Regenerates Primate Hearts The authors demonstrated that allogeneic induced pluripotent stem cells (iPSCs) – cardiomyocytes transplantation is sufficient to regenerate the infarcted non-human primate heart. [Nature] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSScientists sought to study the effect of mechanical conditioning and electrical pacing on the maturation of Human induced pluripotent stem cell (hiPSC)-derived cardiac tissues. Cardiomyocytes derived from hiPSCs were used to generate collagen-based bioengineered human cardiac tissue. [Circulation] Abstract CaMKII Induces Permeability Transition through Drp1 Phosphorylation During Chronic β-AR Stimulation Researchers uncovered a pathway downstream of chronic β-adrenergic receptor (β-AR) stimulation that links Ca2+/calmodulin-dependent kinase II (CaMKII), dynamin-related protein 1 (Drp1) and mitochondrial permeability transition pore (mPTP) to bridge cytosolic stress signal with mitochondrial dysfunction in the heart. [Nat Commun] Full Article Scientists showed that targeting Mll1 dependent H3K4 methyltransferase activity provides specificity in the process of cardiac reprogramming. [Cell Discov] Full Article SKELETAL MUSCLE CELLSInvestigators identified Prox1 as an essential transcription factor that regulates skeletal muscle phenotype and myoblast differentiation by interacting with the NFAT and Notch pathways. [Nat Commun] Full Article | Press Release Researchers showed that TEAD1-expressing skeletal muscle of transgenic mice features a dramatic hyperplasia of muscle stem cells (i.e. satellite cells) but surprisingly without affecting muscle tissue size. [ELife] Full Article | Press Release The authors showed that Krüppel-like factor 5 (Klf5) is also an essential mediator of skeletal muscle regeneration and myogenic differentiation. During muscle regeneration after injury (cardiotoxin injection), Klf5 was induced in the nuclei of differentiating myoblasts and newly formed myofibers expressing myogenin in vivo. [Elife] Abstract | Full Article (Download) S6K1 Is Required for Increasing Skeletal Muscle Force During Hypertrophy The authors report that while not required for muscle growth, S6K1 is essential for maintaining muscle structure and force production. Hypertrophy in the absence of S6K1 is characterized by compromised ribosome biogenesis and the formation of p62-positive protein aggregates. [Cell Rep] Full Article | Graphical Abstract Researchers analyzed myogenic progenitor cells and non-myogenic fibroblast-adipocyte progenitors during cardiotoxin-induced muscle injury uncovered miR-501 as a novel muscle-specific miRNA. [Development] Full Article SMOOTH MUSCLE CELLSMiRNA-145 Inhibits VSMC Proliferation by Targeting CD40 Scientists aimed to determine whether CD40 is involved in miR-145 mediated switch of vascular smooth muscle cells (VSMC) phenotypes. In cultured VSMCs, the effects of miR-145 and CD40 on TNF-α, TGF-β, and Homocysteine (Hcy) induced cell proliferation were evaluated by over-expression of miR-145 or by siRNA-mediated knockdown of CD40. [Sci Rep] Full Article Scientists investigated the impact of deficiency of transforming growth factor (TGFβ) receptors on the structural homeostasis of mature aortas. They used an inducible Cre-loxP system driven by a Myh11 promoter to delete Tgfbr1, Tgfbr2, or both in smooth muscle cells of adult mice. [Sci Rep] Full Article Using human aortic vascular smooth muscle cells, scientists investigated the effects of high fructose treatment on insulin receptor substrate-1 serine phosphorylation, insulin versus platelet-derived growth factor (PDGF)-induced phosphorylation of Akt, S6 ribosomal protein, and extracellular signal-regulated kinase, and cell cycle proteins. [Eur J Pharmacol] Abstract | |
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REVIEWSThe authors discuss the emerging knowledge of miRNAs controlling mitochondrial function and insulin signaling in skeletal muscle cells. [J Cell Physiol] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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SCIENCE NEWSNatera announced that it will present data from Horizon™ carrier screen and Spectrum® pre-implementation genetic screening (PGS) studies. The diverse set of data includes a PGS study on the incidence of triploidy, an underdiagnosed embryo abnormality that is estimated to occur in one to three percent of pregnancies; as well as real-world data that provides important insights on Duchenne muscular dystrophy and makes a compelling case for broad-population carrier screening. [Press release from Natera Inc discussing research presented at the Annual Meeting of the American Society for Reproductive Medicine (ASRM) Conference, Salt Lake City] Press Release | |
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INDUSTRY NEWSIowa State Nets $9.6 Million to Increase STEM Diversity, Prepare Future Faculty Iowa State University has received nearly $10 million in funding from the National Science Foundation to improve diversity in both the professional STEM workforce and academia. [Iowa State University] Press Release Clementia Pharmaceuticals Inc. announced top-line results from its Phase II clinical trial investigating palovarotene for the treatment of fibrodysplasia ossificans progressiva. Palovarotene was well-tolerated, with all subjects completing the 12-week trial and enrolling into the open-label extension trial. [Clementia Pharmaceuticals Inc.] Press Release | |
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POLICY NEWSU.S. And Cuban Biomedical Researchers are Free to Collaborate The U.S. Department of the Treasury has authorized U.S. scientists to freely collaborate with Cuban counterparts on everything from cancer therapies to combating the Zika virus. [Science Insider] Editorial
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EVENTSNEW 28th European Organisation for Research and Treatment of Cancer (EORTC), the National Cancer Institute (NCI) and the American Association for Cancer Research (AACR) SYMPOSIUM Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Scholarship – Skeletal Muscle Molecular Physiology (National University of Ireland Galway) Faculty Position (Tenure) – Cardiovascular Biology (University of Maryland School of Medicine) National Field Product Service Specialist (Cook MyoSite) Research and Development Specialist- Muscle Stem Cell (Nestlé Institute of Health Sciences) Postdoctoral Position – Lipid Metabolism (Baylor College of Medicine) Chair – Medical Biology (Masaryk University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Muscle Cell News Volume 1.28 | Oct 17 2016