Muscle Cell News 1.31 November 7, 2016 | |
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TOP STORYHypoxia Induces Heart Regeneration in Adult Mice The authors found that exposure to hypoxemia 1 week after induction of myocardial infarction induces a robust regenerative response with decreased myocardial fibrosis and improvement of left ventricular systolic function. [Nature] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSCardiac Repair in Guinea Pigs with Human Engineered Heart Tissue from Induced Pluripotent Stem Cells Scientists created human engineered heart tissue strips from human induced pluripotent stem cell (hiPSC)–derived cardiomyocytes and hiPSC-derived endothelial cells. They demonstrated that three-dimensional human heart muscle constructs can repair the injured heart. [Sci Transl Med] Abstract CITED2 Cooperates with ISL1 and Promotes Cardiac Differentiation of Mouse Embryonic Stem Cells The transcriptional regulator CITED2 is essential for heart development. Researchers investigated the role of CITED2 in the specification of cardiac cell fate from mouse embryonic stem cells (ESC). The overexpression of CITED2 in undifferentiated ESC was sufficient to promote cardiac cell emergence upon differentiation. [Stem Cell Reports] Full Article | Graphical Abstract The underlying mechanisms responsible for doxorubicin (DOX)-induced cardiotoxicity has not been completely elucidated. Scientists found that the insulin-like growth factor receptor II (IGF-IIR) apoptotic signaling pathway was responsible for DOX-induced cardiotoxicity via proteasome-mediated heat shock transcription factor 1 (HSF1) degradation. [Cell Death Dis] Full Article Scientists employed a lentiviral knockdown strategy against neutral spingomyelinase 2 (nSMase2), a crucial gene in exosome secretion. The authors defined the role of physiologically secreted human cardiosphere-derived cell-derived exosomes on cardiac fibroblast, endothelial cell and primary cardiomyocyte proliferation, cell death, migration and angiogenesis using a series of in vitro coculture assays. [PLoS One] Full Article SKELETAL MUSCLE CELLSResearchers found that skeletal muscle mitochondria express a unique MCU complex containing an alternative splice isoform of MICU1, MICU1.1, characterized by the addition of a micro-exon that is sufficient to greatly modify the properties of the MCU. [Mol Cell] Abstract | Graphical Abstract Scientists demonstrated an empowering microelectrode array technology for high quality, multisite, long-term electrophysiological recordings from cultured skeletal myotubes. [Sci Rep] Full Article Insights into the Role and Regulation of TCTP in Skeletal Muscle Translationally controlled tumor protein (TCTP) overexpression inhibited the promoter activity of the muscle-specific ubiquitin proteasome E3-ligase, MuRF1, suggesting that TCTP may play a role in inhibiting protein degradation. The authors provide novel data on the role and regulation of TCTP in skeletal muscle in vivo. [Oncotarget] Full Article Researchers hypothesized that decreased lattice spacing, achieved through increased sarcomere length or osmotic compression of the fiber via dextran T-500, could slow MgADP release rate and increase cross-bridge attachment duration. They measured cross-bridge cycling and MgADP release rates in skinned soleus fibers using stochastic length-perturbation analysis at 2.5 and 2.0 μm sarcomere lengths as pCa and [MgATP] varied. [Biophys J] Abstract SMOOTH MUSCLE CELLSInvestigators hypothesized that, in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension, decreases in hypoxia inducible factor-1α expression and activity underlie augmented pulmonary vascular contractility. [FASEB J] Abstract Moderate Hyperoxia Induces Extracellular Matrix Remodeling by Human Fetal Airway Smooth Muscle Cells Researchers assessed the impact of 24-72 h of moderate hyperoxia (50%) on human fetal airway smooth muscle extracellular matrix deposition through western blot, modified in-cell western, and zymography techniques. [Pediatr Res] Abstract Activating Transcription Factor-4 Promotes Mineralization in Vascular Smooth Muscle Cells The authors demonstrated the pathophysiological role of activating transcription factor-4 (ATF4) in vascular calcification using global Atf4 KO, smooth muscle cell–specific Atf4 KO, and transgenic mouse models. [JCI Insight] Full Article | |
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REVIEWSStem cell therapy (SCT) raises the hope for cardiac regeneration in ischemic hearts. Growing evidences suggest that cardiac matrix stiffness and differential expressions of miRNAs play a crucial role in stem cell survival and differentiation. However, their roles on transplanted stem cells, for myocardial repair of the ischemic heart, remain unclear. The authors discuss the specific roles of these regulatory components on cardiac regeneration in the ischemic heart during SCT. [Stem Cell Rev] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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SCIENCE NEWSCapricor Therapeutics Presents Positive 12-Month Results from DYNAMIC at TCT 2016 Capricor Therapeutics, Inc. announced detailed results from its DYNAMIC clinical trial of CAP-1002 in patients with advanced heart failure. [Press release from Capricor Therapeutics, Inc. discussing research presented at 28th Transcatheter Cardiovascular Therapeutics (TCT), Washington D.C.] Press Release | |
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INDUSTRY NEWSRenova™ Therapeutics, a biotechnology company developing gene therapy treatments for congestive heart failure and type 2 diabetes, announced that it has completed an End-of-Phase II meeting with the U.S. Food and Drug Administration (FDA) for its lead gene therapy product candidate, RT-100 AC6 gene transfer for the treatment of patients with heart failure and reduced ejection fraction. [Renova™ Therapeutics] Press Release Over Half a Billion in Research Council Grant to Karolinska Institute (KI) Researchers The Swedish Research Council announced the grants it will be awarding in the category of medicine and health. The total sum is almost 980 million Swedish krona (SEK), of which KI researchers will receive SEK 524,325,017. [Karolinska Institute] Press Release Cedars-Sinai Receives Approval to Test Novel Combined Stem Cell and Gene Therapy for ALS Patients Cedars-Sinai regenerative medicine investigators have received approval from the U.S. Food and Drug Administration to test a combination stem cell-gene therapy they developed to stall the progression of amyotrophic lateral sclerosis (ALS), a neurological disease that causes progressive paralysis and ultimately death. [Cedars-Sinai] Press Release | |
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POLICY NEWSTracker Flags up Failures to Report Clinical Trials An automated tool has trawled through thousands of records on the world’s leading clinical-trials database to reveal which drug firms and academic institutions are failing to publish the results of their trials. The US Department of Health and Human Services announced tougher rules to push the researchers that it funds to publish clinical-trial designs and results. [Nature News] Editorial Publisher Pulls 58 Articles by Iranian Scientists over Authorship Manipulation A tranche of 58 articles authored by 282 Iran-based researchers were retracted by a leading scientific publisher, which said it had found signs that the peer review and publication processes had been compromised. [Nature News] Editorial Hard Work, Little Reward: Nature Readers Reveal Working Hours and Research Challenges A poll answered by thousands of Nature readers suggests that nearly two-thirds have considered quitting research, and that almost 40% work more than 60 hours in a week. The fight for funding is the greatest challenge facing early-career scientists, readers said. [Nature] Editorial Twitterstorm Shows Why Scientific Evidence Matters Grammar and Twitter rarely sit happily, so it would be churlish to point out that when the Welsh MP Glyn Davies tweeted at the weekend: “Nothing more irritating than academics rubbishing the efforts of those operating at the sharp end, without facing up to the hard decisions”, he was inadvertently complaining that people at the sharp end (himself included presumably) do not confront hard decisions. [Nature] Editorial
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EVENTSNEW 19th International Conference on Clinical Application of Adult Stem Cells Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Associate – Integrative Biology & Physiology (University of Minnesota) Postdoctoral Position – Muscle Biology (Umeå University) Research Associate – Craniofacial Development and Stem Cell Biology (King’s College London) Assistant Professor – Biomedical Engineering (Univesrity of South Dakota) Faculty Position (Tenure) – Cardiovascular Biology (University of Maryland School of Medicine) National Field Product Service Specialist (Cook MyoSite) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Muscle Cell News Volume 1.31 | Nov 7 2016