Muscle Cell News 2.05 February 20, 2017 | |
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TOP STORYA Twist2-Dependent Progenitor Cell Contributes to Adult Skeletal Muscle By lineage tracing of progenitor cells expressing the Twist2 transcription factor in mice, scientists discovered a myogenic lineage that resides outside the basal lamina of adult skeletal muscle. [Nat Cell Biol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSResearchers used human induced pluripotent stem cell–derived cardiomyocytes, generated from 11 healthy individuals and 2 patients receiving cancer treatment, to screen U.S. Food and Drug Administration–approved tyrosine kinase inhibitors for cardiotoxicities by measuring alterations in cardiomyocyte viability, contractility, electrophysiology, calcium handling, and signaling. [Sci Transl Med] Abstract Scientists sought to determine whether dectin-2 signaling is involved in the healing process and cardiac remodeling after myocardial infarction (MI), and to elucidate the underlying molecular mechanisms. They found dectin-2 leads to an increase in cardiac rupture, impairs wound healing, and aggravates cardiac remodeling after MI through the modulation of Th1 differentiation. [Circ Res] Abstract Proteolysis Regulates Cardiomyocyte Maturation and Tissue Integration Investigators showed that proteolysis, via the E3 ubiquitin ligase ASB2, regulates cardiomyocyte maturation and tissue integrity. Their results show that proteolysis has an important role in cardiomyocyte maturation and the formation of a coherent myocardial tissue. [Nat Commun] Full Article Cardiosphere-Derived Cells Do Not Improve Cardiac Function in Rats with Cardiac Failure Researchers challenged the effectiveness of cardiosphere-derived cells (CDC) in post-ischemic heart failure. They evaluated the therapeutic potential of CDC 60 days after myocardial infarction in a rat model. [Stem Cell Res Ther] Full Article SKELETAL MUSCLE CELLSThe authors developed multiple approaches for editing the mutation in dystrophic mdx4cv mice using single and dual adeno-associated viral vector delivery of a muscle-specific Cas9 cassette together with single-guide RNA cassettes and, in one approach, a dystrophin homology region to fully correct the mutation. [Nat Commun] Full Article Scientists showed that silencing of either Tead1, Tead2 or Tead4 did not effect primary myoblast (PM) differentiation, but that their simultaneous knockdown strongly impaired differentiation. In contrast, Tead1 or Tead4 silencing impaired C2C12 differentiation showing their different contributions in PMs and C2C12 cells [PLoS Genet] Full Article Researchers hypothesized muscle regeneration defects are caused by impaired muscle stem cell differentiation. Myogenic progenitors derived from emerin-null mice were used to confirm their impaired differentiation and analyze selected myogenic molecular pathways [Dis Model Mech] Abstract | Full Article SMOOTH MUSCLE CELLSInvestigators attempted to elucidate the signal pathway of the glycocalyx mechanotransduction in shear stress regulated smooth muscle cells contraction. [Sci Rep] Full Article Scientists tested the hypothesis that hypoxia-induced arginase II expression in pulmonary artery smooth muscle cell is mediated through adenosine monophosphate-activated protein kinase signaling. [Am J Physiol Lung Cell Mol Physiol] Abstract Researchers developed a thermoresponsive cell culture platform for growing aligned vascular smooth muscle cell sheets by photografting N-isopropylacrylamide onto micropatterned poly(dimethysiloxane). [Macromol Biosci] Abstract | |
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REVIEWSGeneration of Induced Cardiac Progenitor Cells via Somatic Reprogramming The authors discuss the emerging interest in generating cardiac progenitor cells-like stem cells from somatic cells via somatic reprogramming. This novel approach would provide an unlimited source of stem cells with cardiac differentiation potential. [Oncotarget] Full Article Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSFDA Approves Drug to Treat Duchenne Muscular Dystrophy The U.S. Food and Drug Administration approved Emflaza tablets and oral suspension to treat patients age five years and older with Duchenne muscular dystrophy, a rare genetic disorder that causes progressive muscle deterioration and weakness. Emflaza is a corticosteroid that works by decreasing inflammation and reducing the activity of the immune system. [The U.S. Food and Drug Administration] Press Release Capricor Therapeutics Provides Update on Natriuretic Peptide Program Capricor Therapeutics, Inc. announced that it has elected to terminate its license agreement with the Mayo Clinic relating to natriuretic peptide receptor agonists, including Cenderitide. [Capricor Therapeutics, Inc.] Press Release | |
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POLICY NEWSDelay in Hiring Science Advisers Intensifies Brexit Worries Policy experts want scientists to be at the table when government decides on environmental protection and membership of international collaborations. [Nature News] Editorial Why the CRISPR Patent Verdict Isn’t the End of the Story The US Patent and Trademark Office issued a key verdict this week in the battle over the intellectual property rights to the potentially lucrative gene-editing technique CRISPR–Cas9. But the fight for patent rights to CRISPR technology is by no means over. [Nature News] Editorial
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EVENTSNEW Stem Cells and Regenerative Medicine 2nd International Congress NEW The Biology of Regenerative Medicine Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Scientist – Cardiovascular Research (Rutgers New Jersey Medical School) NEW Postdoctoral Candidate – Cardiovascular Biology and Disease (University at Buffalo) Postdoctoral Fellow – Cell and Gene Therapy for Cardiac Arrhythmias (Duke University) Postdoctoral Fellow – Genome Editing for Cardiac Muscle Regeneration (Duke University) Postdoctoral Position – In Vitro Modeling of Human Skeletal Muscle Disease (Duke University) Postdoctoral Fellow – hiPSC-based Heart Repair (Duke University) Postdoctoral Researcher – Muscle Biology and Muscle Disease (University of Pennsylvania) Assistant/Associate Professor – Physiology and Cell Biology (University of Nevada) Postdoctoral Fellow – Cardiovascular Research (Thomas Jefferson University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Muscle Cell News Volume 2.05 | Feb 20 2017