Muscle Cell News 3.07 March 5, 2018 | |
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TOP STORYUnlocking a Cell’s Potential to Regenerate the Heart Researchers developed the first efficient and stable method to make adult cardiomyocytes divide and repair hearts damaged by heart attacks, at least in animal models. [Press release from the Gladstone Institutes discussing online prepublication in Cell] Press Release | Abstract | Editorial | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSSETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation Scientists showed that the H3K4 methyltransferase SETD7 controls cardiac differentiation by reading H3K36 marks independently of its enzymatic activity. Through chromatin immunoprecipitation sequencing, researchers found that SETD7 targets distinct sets of genes to drive their stage-specific expression during cardiomyocyte differentiation. [Cell Stem Cell] Abstract | Graphical Abstract Contractile Work Contributes to Maturation of Energy Metabolism in hiPSC-Derived Cardiomyocytes To assess whether cultivation of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in 3D engineered heart tissue format leads to maturation of energy metabolism, the authors analyzed the mitochondrial and metabolic state of 3D hiPSC-CMs and compared it with 2D culture. [Stem Cell Reports] Full Article | Graphical Abstract Investigators isolated cardiac progenitor cells and compared mouse strains with different telomere lengths for phenotypic characteristics of aging. Wild mouse strain Mus musculus castaneus possessing short telomeres exhibited early cardiac aging with cardiac dysfunction, hypertrophy, fibrosis, and senescence, as compared with common lab strains FVB and C57 bearing longer telomeres. [Stem Cells] Abstract SKELETAL MUSCLE CELLSSomatic Mutagenesis in Satellite Cells Associates with Human Skeletal Muscle Aging To study the connection between satellite cell (SC) aging and muscle impairment, scientists analyzed the whole genome of single SC clones of the leg muscle vastus lateralis from healthy individuals of different ages. They found an accumulation rate of 13 somatic mutations per genome per year, consistent with proliferation of SCs in the healthy adult muscle. [Nat Commun] Full Article | Press Release | Editorial High-Yield Purification, Preservation, and Serial Transplantation of Human Satellite Cells Researchers describe a robust and predictable human satellite cell purification process that is effective for each human skeletal muscle tested and the development of storage protocols and transplantation models in dystrophin-deficient and wild-type recipients. [Stem Cell Reports] Full Article miR-27b Regulates Myogenic Proliferation and Differentiation by Targeting Pax3 in Goat Investigators found that miR-27 is expressed in muscle and regulates muscle proliferation and differentiation. They explored the function and regulatory mechanism of miR-27b in goat muscle proliferation and differentiation. [Sci Rep] Full Article SMOOTH MUSCLE CELLSScientists examined the effects of the niclosamide on vascular smooth muscle cell proliferation, migration, and neointimal hyperplasia and elucidated the potential mechanisms. [Br J Pharmacol] Abstract Investigators showed that ARF GTPases are actively involved in vascular smooth muscle cell phenotypic switching through the regulation of actin function in migration and proliferation, and the control of actin dependent gene regulation. [Cell Signal] Abstract Autologous Smooth Muscle Progenitor Cells Enhance Regeneration of Tissue-Engineered Bladder Researchers demonstrated that smooth muscle progenitor cells (SPCs) from the peripheral blood could enhance histological regeneration and functional recovery of the tissue-engineered neobladder through both the direct integration and indirect paracrine effect, supporting the use of SPCs as the cell sources for tissue engineering of the bladder. [Tissue Eng Part A] Abstract PM2.5 Promotes Human Bronchial Smooth Muscle Cell Migration via the Sonic Hedgehog Signaling Pathway Scientists aimed to verify the effects of fine particulate matter on human bronchial smooth muscle cell migration and to explore the underlying signaling pathways. [Respir Res] Full Article | |
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REVIEWSRedox Control of Vascular Smooth Muscle Cell Function and Plasticity The authors summarize current knowledge of how disruptions to redox balance can functionally change vascular smooth muscle cells (SMCs) and how this may influence vascular disease pathogenesis. Specifically, they focus on the current understanding of the role of vascular nicotinamide adenine dinucleotide phosphate oxidases 1, 4, and 5 in SMC function. [Lab Invest] Abstract Researchers provide a brief introduction into stem cell therapies for ischemic heart disease. They summarize cell-based and cell-free paradigms, their limitations, and the benefits of using them to target disease. [Stem Cells Transl Med] Full Article Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSThe Cell and Gene Therapy Catapult announced it has signed a Memorandum of Understanding with the Japanese Society for Regenerative Medicine (JSRM). This agreement between the CGT Catapult and JSRM aims to advance regenerative medicine and cell and gene therapies in both the UK and Japan. [The Cell and Gene Therapy Catapult] Press Release Smithfield Bioscience and University of Virginia Announce Regenerative Medicine Research Partnership Smithfield Foods, Inc. and the University of Virginia School of Engineering & Applied Science announced a research partnership to explore and advance regenerative medicine technologies leveraging porcine bioproducts. The research is part of a collaborative project between UVA and Smithfield Bioscience, a strategic business platform within Smithfield Foods that is focused on supporting a range of biotechnology solutions in areas of human therapeutics, tissue fabrication and regenerative medicine. [Smithfield Foods, Inc.] Press Release | |
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POLICY NEWSNew NSF Rules on Sexual Harassment Leave Many Questions Unanswered The National Science Foundation (NSF) in Alexandria, Virginia, hopes that its new policy on sexual harassment will spur universities to deal more aggressively with the pervasive problem. But the additional reporting requirements, which will be officially published in the Federal Register, are far from a definitive statement about how NSF plans to deal with this complex and sensitive subject. [ScienceInsider] Editorial EU Research Chief’s Next Act: Changing the Future of Academic Publishing Robert-Jan Smits, one of Europe’s most powerful figures in research, has been appointed as a special envoy on open science at the European Commission, to help push efforts to make all publicly funded research in Europe freely available by 2020. [Science|Business] Editorial Here’s How the Scientists Running for Office Are Doing They’re trained problem-solvers, but they have to learn to move beyond data to run successful campaigns. [The Atlantic] Editorial Canadian Science Wins Billions in New Budget Canadian Prime Minister Justin Trudeau’s administration released its 2018 budget and scientists couldn’t be happier. It includes almost CAD 4 billion (USD 3.1 billion) in new funding for science over the next five years, a significant portion of which will go to the country’s three granting councils. [Nature News] Editorial
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EVENTSNEW Gordon Research Conferences: Extracellular Vesicles Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Director – Whitaker Cardiovascular Institute (Boston University) NEW Postdoctoral fellowship – Basic and Translational Heart Failure (University of South Florida) Postdoctoral Position – Stem Cell Biology (University of California, Los Angeles) Fellowship – Cardio-Biology (Johns Hopkins University) Postdoctoral Associate – Bioengineering (University of Pittsburgh) Principal Investigator – Cardiology (Boston Children’s Hospital) Postdoctoral Fellow – Metabolic Regulation (Harvard University) Faculty Position – Translational Research in Cardiac Biology (Temple University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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