Muscle Cell News 3.09 March 19, 2018 | |
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TOP STORYTransient HIF2A Inhibition Promotes Satellite Cell Proliferation and Muscle Regeneration The authors report that satellite cells are in an intrinsic hypoxic state in vivo and express hypoxia-inducible factor 2A (HIF2A). HIF2A promotes the stemness and long-term homeostatic maintenance of satellite cells by maintaining the quiescence, increasing the self-renewal and blocking the myogenic differentiation of satellite cells. [J Clin Invest] Abstract | Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSScientists showed that while cylindrical patterns on the substrates resembling mature cardiomyocytes (CMs) enhance the maturation of induced pluripotent stem cell CMs, sub‐micrometer‐level topographical features derived by imprinting primary human CMs further accelerated both the differentiation and maturation processes. [Adv Funct Mater] Abstract | Press Release To experimentally model early cardiac organogenesis in vitro, this protocol combines biomaterials-based cell patterning with stem cell organoid engineering. [Nat Protoc] Full Article | Press Release Myocardial Bmp2 Gain Causes Ectopic EMT and Promotes Cardiomyocyte Proliferation and Immaturity Using a mouse transgenic line conditionally expressing Bmp2, researchers showed that widespread Bmp2 expression in the myocardium leads to valve and chamber dysmorphogenesis and embryonic death by E15.5. Transgenic embryos showed thickened valves, ventricular septal defect, enlarged trabeculae and dilated ventricles, with an endocardium able to undergo EMT both in vivo and in vitro. [Cell Death Dis] Full Article Investigators examined whether suxiao jiuxin pill treatment altered cardiac mesenchymal stem cells-derived exosomes to cause epigenetic chromatic remodeling in recipient cardiomyocytes. [Acta Pharmacol Sin] Abstract SKELETAL MUSCLE CELLSBasal Lamina Remodeling at the Skeletal Muscle Stem Cell Niche Mediates Stem Cell Self-Renewal Researchers showed that upon activation, skeletal muscle stem cells induce local remodeling of the extra-cellular matrix and the deposition of laminin-α1 and laminin-α5 into the basal lamina of the satellite cell niche. [Nat Commun] Full Article Scientists developed and tested a new human stem cell-based approach to increase engraftment, limit rejection, and restore dystrophin expression in the mdx/scid mouse model of Duchenne Muscular Dystrophy (DMD). They introduced two DEC cell lines created by ex vivo fusion of human myoblasts (MB) derived from two normal donors (MBN1/MBN2), and normal and DMD donors (MBN/MBDMD). [Stem Cell Rev] Abstract | Press Release Investigators analyzed the histology and the transcriptomic changes occurring at E14.5 –the end of primary myogenesis and around the onset of intrauterine limb movement, and at E18.5 –the end of secondary myogenesis, in WT, type 1 ryanodine receptor (RYR1)-/-, and Cav1.1-/- murine limb skeletal muscle. [PLoS One] Full Article SMOOTH MUSCLE CELLSHuman and murine vascular smooth muscle cells (VSMCs) were differentiated into functional osteoblast-like cells by hyperphosphatemia (HPM) conditioning. Murine VSMCs from transgenic mice overexpressing lysyl oxidase exhibited an increase in HPM-dependent calcification and osteoblast commitment compared with wild-type cells. [FASEB J] Abstract Using vascular smooth muscle cells (VSMCs) from the vasculature of the human umbilical cord, placenta and cerebrum of cerebral autosomal‐dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients, researchers found that CADASIL VSMCs had a lower proliferation rate compared to control VSMCs. [J Cell Mol Med] Abstract | Full Article Functional roles of type 3 ryanodine receptors (RyR3) in the regulation of Ca2+ signaling in mesenteric artery smooth muscle cells were examined using RyR3 homozygous knockout mice. [Am J Physiol Cell Physiol] Abstract | |
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REVIEWSImmunology Guides Skeletal Muscle Regeneration The authors focus on the initial physiological pathways following skeletal muscle trauma in comparison to bone and tendon trauma and what conclusions can be drawn from new scientific insights for the development of novel therapeutic strategies. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSSummit Expands Enrolment in PhaseOut DMD Phase II Clinical Trial to Include Planned Additional Group Summit Therapeutics plc announced it has opened enrolment in a planned additional group in its Phase II open label clinical trial called PhaseOut DMD. [Summit Therapeutics plc] Press Release AMO Pharma Limited announced the presentation of final data from the company’s Phase II proof-of-concept study of AMO-02, an investigational therapy for treatment of congenital and childhood onset myotonic dystrophy type 1. [AMO Pharma Limited (PR Newswire Association LLC.)] Press Release Missouri Researcher Wins $50,000 Sheila Essey Award: An Award for ALS Research The American Academy of Neurology, The ALS Association and the American Brain Foundation are awarding the 2018 Sheila Essey Award to Timothy M. Miller, MD, PhD, from the Washington University School of Medicine in St. Louis, Mo., and a member of the American Academy of Neurology. The award recognizes significant research contributions in the search for the causes, prevention and cure for amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. [American Academy of Neurology (Newswise, Inc.)] Press Release | |
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POLICY NEWSReporter’s Notebook: House Budget Hearing Shows Science Chairman’s Impact on NSF Peer Review Representative Lamar Smith has repeatedly criticized the peer-review process at the National Science Foundation (NSF) in Alexandria, Virginia, since becoming chairman of the U.S. House of Representatives’s science committee in 2013. It was no surprise, then, that during a hearing on NSF’s 2019 budget request he railed against a handful of grants from NSF’s $6 billion research portfolio as a waste of taxpayer dollars. [ScienceInsider] Editorial ‘Right-to-Try’ Bill Rejected by House, in Major Blow to GOP Efforts In a major blow to the effort to pass a federal “right-to-try” law, House Republicans failed to muster the votes to pass a key compromise measure. [STAT News] Editorial Springer Nature and VSNU Renew Agreement on Open Access Publishing Springer Nature and the Association of Universities in the Netherlands (VSNU) have renewed their agreement to secure open access publishing for Dutch universities up to 2021. [The Association of Universities in the Netherlands] Editorial Science ‘Champion’ Dan Lipinski Faces Tough Race in Illinois Primary Representative Daniel Lipinski—an anti-abortion Democrat who voted against the Affordable Care Act and who only recently has embraced a path to citizenship for undocumented immigrants—knows that he’s out of step with progressives on many social issues. Lipinski will find out whether voters in Illinois’s third congressional district on Chicago’s southwest side feel there’s still room for him in the Democratic Party. [ScienceInsider] Editorial
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EVENTSNEW NAVBO: Vasculata™ 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Molecular Cardiology (National Center for Cardiovascular Research) Postdoctoral Research Assistant – Cardiovascular Medicine (University of Oxford) Director – Whitaker Cardiovascular Institute (Boston University) Postdoctoral Fellowship – Basic and Translational Heart Failure (University of South Florida) Postdoctoral Position – Stem Cell Biology (University of California, Los Angeles) Fellowship – Cardio-Biology (Johns Hopkins University) Postdoctoral Associate – Bioengineering (University of Pittsburgh) Principal Investigator – Cardiology (Boston Children’s Hospital) Postdoctoral Fellow – Metabolic Regulation (Harvard University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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