Muscle Cell News 3.10 March 26, 2018 | |
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TOP STORYUHRF1 Epigenetically Orchestrates Smooth Muscle Cell Plasticity in Arterial Disease Researchers demonstrated the role of ubiquitin-like, containing PHD and RING finger domains, 1 (UHRF1) as an epigenetic master regulator of vascular smooth muscle cells plasticity. [J Clin Invest] Abstract | Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSInvestigators assessed the appropriateness of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a model to recapitulate some aspects of the pathogenetic mechanism involving cardiac manifestations in myotonic dystrophy type 1 patients. [J Mol Cell Cardiol] Abstract | Graphical Abstract Mechanical Stretch Induced Transcriptomic Profiles in Cardiac Myocytes Scientists used Ingenuity Pathway Analysis to predict functional pathways and upstream regulators of differentially expressed genes in order to identify regulatory networks that may lead to mechanical stretch induced hypertrophic growth of cardiomyocytes. [Sci Rep] Full Article ENPP2 Protects Cardiomyocytes from Erastin-Induced Ferroptosis The authors showed that ENPP2, as a lipid kinase involved in lipid metabolism, protects against erastin-induced ferroptosis in cardiomyocytes. They observed that ENPP2 overexpression regulates ferroptosis-associated gene GPX4, ACSL4 and NRF2 expression and modulates MAPK and AKT signal in H9c2 cells. [Biochem Biophys Res Commun] Abstract SKELETAL MUSCLE CELLSFusogenic Micropeptide Myomixer Is Essential for Satellite Cell Fusion and Muscle Regeneration To investigate the role of Myomixer in muscle regeneration, researchers used CRISPR/Cas9-mediated genome editing to generate conditional knockout Myomixer alleles in mice. They showed that genetic deletion of Myomixer in satellite cells using a tamoxifen-regulated Cre recombinase transgene under control of the Pax7 promoter abolished satellite cell fusion and prevented muscle regeneration, resulting in severe muscle degeneration after injury. [Proc Natl Acad Sci USA] Abstract This protocol resulted in improved in vitro differentiation and maturation of mouse muscle fibers over serum-free protocols and enabled the study of myogenic cell fusion and satellite cell differentiation. [Development] Abstract Modulation of the Neuregulin 1/ErbB System after Skeletal Muscle Denervation and Reinnervation Scientists performed a detailed time-course expression analysis of several neuregulin 1 isoforms and ErbB receptors in the rat superficial digitorum flexor muscle after three types of median nerve injuries of different severities. They found that ErbB receptor expression was correlated with the innervated state of the muscle, with upregulation of ErbB2 clearly associated with the denervation state. [Sci Rep] Full Article The authors found expression of potential fibroblast growth factor 23 receptors and α-Klotho in muscles of two animal models as well as C2C12 myoblasts and myotubes. [Am J Physiol Endocrinol Metab] Abstract Self-Folded Hydrogel Tubes for Implantable Muscular Tissue Scaffolds The development of a recapitulated fascicle-like implantable muscle construct by programmed self-folding of poly(ethylene glycol) diacrylate hydrogels is reported. The system comprised two stacked layers, each with differential swelling degrees, stiffnesses, and thicknesses in 2D, which folds into a 3D tube together. Inside the tubes, muscle cell adhesion and their spatial alignment were controlled. [Macromol Biosci] Abstract SMOOTH MUSCLE CELLSResearchers investigated the binding modes of 20(R/S)‐Rg3 stereoisomers in the peroxisome proliferator‐activated receptor gamma (PPARγ) ligand‐binding domain (PPARγ‐LBD) using molecular modeling and their effects on smooth muscle cell proliferation and migration induced by advanced glycation end products. [J Cell Mol Med] Abstract | Full Article Scientists investigated whether astragaloside IV inhibited agonist-induced vascular smooth muscle cells proliferation and the underlying mechanism. [Life Sci] Abstract | |
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REVIEWSThe authors focus on the current developments in the effects of mitochondrial fusion and fission on cardiomyocyte functions, the implications for cardiomyocyte apoptosis in response to ischemia/reperfusion, and possible mechanisms. [J Cell Physiol] Abstract Scientists present biological properties of mesenchymal stem/stromal cells of bone marrow origin and a heterogeneous population of muscle-resident stem/progenitor cells, their interaction with the inflammatory environment of dystrophic muscle and potential implications for cellular therapies for muscle regeneration. [Arch Immunol Ther Exp (Warsz)] Full Article Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSFlex Pharma, Inc. under FDA Fast Track designation announced positive topline data for FLX-787 from its exploratory Phase II trial in multiple sclerosis patients with frequent muscle cramps/spasms and spasticity. [Flex Pharma, Inc.] Press Release GT Biopharma Inc. announced that it has completed the analysis of pharmacokinetic data from its Phase I clinical trial for GTP-004, its promising treatment for the symptoms of myasthenia gravis. [GT Biopharma Inc.] Press Release BIOPHYTIS Files for Orphan Drug Designation for Sarconeos in Duchenne Muscular Dystrophy BIOPHYTIS announced that it has filed for orphan drug designation with the European Medicines Agency and presents MYODA, the new clinical program of Sarconeos in Duchenne Muscular Dystrophy. [BIOPHYTIS] Press Release | |
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POLICY NEWSDuke’s Mishandling of Misconduct Prompts New U.S. Government Grant Oversight Last week, the U.S. National Institutes of Health imposed unusual new requirements on researchers based at Duke University in Durham, North Carolina, who receive federal funds. The changes are a response to concerns over how the institution handled recent cases involving research misconduct and grant management. [ScienceInsider] Editorial Massive Cyberhack by Iran Allegedly Stole Research from 320 Universities, Governments, and Companies Nine Iranians working on behalf of the Islamic Revolutionary Guard Corps hacked the computers of 7998 professors at 320 universities around the world over the past five years, an indictment filed by a federal grand jury alleges. [ScienceInsider] Editorial Final 2018 Budget Deal Should Help the National Science Foundation in 2019, Too The 4% increase for the National Science Foundation (NSF) in Alexandria, Virginia, in the 2018 omnibus spending bill hammered out by congressional leaders this week may be modest next to what its peer science agencies received. But it does offer NSF officials more breathing room to fund some major initiatives starting next year. [ScienceInsider] Editorial Final 2018 Budget Bill Eases Biomedical Researchers’ Policy Worries The 2018 omnibus spending bill released yesterday is cheering biomedical researchers. Not only because of the 8.8% raise it gives the National Institutes of Health—its largest in 15 years—but also because it blocks or drops several proposed policy changes that had concerned the community. [ScienceInsider] Editorial
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EVENTSNEW 3D Cell Culture 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Scientist – Regenerative Medicine (University of Oxford) NEW Research Associate – Vascular Smooth Muscle Cells (University of Bristol) Postdoctoral Researcher – Molecular Cardiology (National Center for Cardiovascular Research) Postdoctoral Position – Cancer, Immunotherapy, and Fibrosis (University of Alabama at Birmingham) Postdoctoral Research Assistant – Cardiovascular Medicine (University of Oxford) Director – Whitaker Cardiovascular Institute (Boston University) Postdoctoral Fellowship – Basic and Translational Heart Failure (University of South Florida) Fellowship – Cardio-Biology (Johns Hopkins University) Postdoctoral Associate – Bioengineering (University of Pittsburgh) Principal Investigator – Cardiology (Boston Children’s Hospital) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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