Muscle Cell News 3.23 July 9, 2018 | |
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TOP STORYInvestigators showed that transplantation of ~750 million cryopreserved human embryonic stem cell-derived cardiomyocytes enhances cardiac function in macaque monkeys with large myocardial infarctions. [Nat Biotechnol] Abstract | Full Article | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSTreg-conditioned medium promoted cardiomyocyte proliferation, similar to the serum from pregnant animals. Proliferative cardiomyocytes were detected in the heart of pregnant mothers, and Treg depletion during pregnancy decreased both maternal and fetal cardiomyocyte proliferation. [Nat Commun] Full Article Investigators showed that canonical TGF-β signaling promotes senescence via miR-29-induced loss of H4K20me3. Loss of H4K20me3 mediated by the senescent TGF-β/miR-29 pathway contributed to cardiac aging in vivo. [Nat Commun] Full Article A human 3D cardiac microtissue containing human induced pluripotent stem cell-derived cardiomyocytes, cardiac endothelial cells and cardiac fibroblasts was used to assess their suitability to detect drug induced changes in cardiac structure. [Sci Rep] Full Article ETV1 Activates a Rapid Conduction Transcriptional Program in Rodent and Human Cardiomyocytes Scientists demonstrated that ETV1 (ER81)-dependent gene networks dictate the unique electrophysiological characteristics of atrial and His-Purkinje myocytes. Cardiomyocyte-specific deletion of ETV1 resulted in cardiac conduction abnormalities, decreased expression of rapid conduction genes, His-Purkinje system hypoplasia, and ventricularization of the unique sodium channel properties that define Purkinje and atrial myocytes in the adult heart. [Sci Rep] Full Article SKELETAL MUSCLE CELLSSkeletal Muscle Stem Cells from PSC-Derived Teratomas Have Functional Regenerative Capacity Investigators showed that teratomas formed in adult skeletal muscle differentiate in vivo to produce large numbers of α7-Integrin+ VCAM-1+ myogenic progenitors. [Cell Stem Cell] Full Article | Press Release | Graphical Abstract MEK Inhibition Induces MYOG and Remodels Super-Enhancers in RAS-Driven Rhabdomyosarcoma Researchers demonstrated that oncogenic RAS, acting through the RAF-MEK [mitogen-activated protein kinase (MAPK) kinase]-ERK (extracellular signal-regulated kinase) MAPK effector pathway, inhibits myogenic differentiation in rhabdomyosarcoma by repressing the expression of the prodifferentiation myogenic transcription factor, MYOG. [Sci Transl Med] Abstract A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription in trans Depletion of either cohesin or DRReRNA reduced chromatin accessibility, prevented myogenin activation, and hindered muscle cell differentiation. [Mol Cell] Abstract | Graphical Abstract Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis Investigators showed that deletion of the highly conserved Rbfox1 and Rbfox2 alternative splicing regulators in adult mouse skeletal muscle causes rapid, severe loss of muscle mass. [Cell Rep] Full Article | Graphical Abstract Scientists found that hepatocyte growth factor expression was upregulated in skeletal muscle tissue following surgical denervation and in hSOD1-G93A transgenic mice showing severe muscle loss. [Mol Ther Nucleic Acids] Abstract | Graphical Abstract SMOOTH MUSCLE CELLSStimulation of muscularis macrophages via transient receptor potential vanilloid 4 (TRPV4) promoted the release of prostaglandin E2 and elicited colon contraction in a paracrine manner via prostaglandin E receptor signaling in intestinal smooth muscle cells without input from the enteric nervous system. [Immunity] Abstract | Graphical Abstract Through silencing distinct Notch receptors, the authors identified that Notch1 mainly mediated cartilage oligomeric matrix protein-initiated embryonic stem cell-vascular smooth muscle cell differentiation. [J Mol Cell Cardiol] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & ESC & iPSC News. | |
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REVIEWSThe Epicardium as a Hub for Heart Regeneration Scientists describe recent advances in the understanding of the biology of the epicardium and the effect of these findings on the candidacy of this structure as a therapeutic target for heart repair and regeneration. [Nat Rev Cardiol] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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SCIENCE NEWSSanthera Pharmaceuticals announced that new data further supporting the clinical relevance of Peak Expiratory Flow and providing a link between the treatment effect of idebenone observed in the pivotal Phase III DELOS study and measures of disease progression will be presented. [Press release from Santhera Pharmaceuticals discussing research to be presented at the 15th International Congress on Neuromuscular Diseases (ICNMD), Vienna] Press Release | |
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INDUSTRY NEWSGrant to Explore Genome Editing and Stem Cell Potential for Cardiac Treatment Examining the treatment potential of cardiac cells derived from human pluripotent stem cells may lead to dramatically altering the care of cardiac disease and heart injuries, thanks to a grant from the National Institutes of Health. [The Pennsylvania State University] Press Release Catabasis Pharmaceuticals, Inc. announced plans for the Phase III POLARIS DMD trial with edasalonexent in patients with Duchenne muscular dystrophy. [Catabasis Pharmaceuticals, Inc.] Press Release Axovant Sciences announced that it has licensed exclusive global rights to an investigational Silence-and-Replace gene therapy program from Benitec Biopharma for the treatment of oculopharyngeal muscular dystrophy. [Axovant Sciences (GlobeNewswire, Inc.)] Press Release Orion Has Started a Phase III Trial to Develop a Drug for ALA – the Patient Recruitment Has Begun Orion has recruited the first patients in the Phase III clinical trial in which orally administered levosimendan is being evaluated for the treatment of symptoms of amyotrophic lateral sclerosis (ALS). [Orion (GlobeNewswire, Inc.)] Press Release Summit Announces PhaseOut DMD Did Not Meet Primary Endpoint Summit Therapeutics plc announced PhaseOut DMD has not met its primary or secondary endpoints after 48 weeks of treatment of ezutromid in patients with Duchenne muscular dystrophy. [Summit Therapeutics plc (GlobeNewswire, Inc.)] Press Release | |
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POLICY NEWSThe country is making a serious investment in becoming a world-class science superpower. [Scientific American] Editorial Hidden Conflicts? Pharma Payments to FDA Advisers after Drug Approvals Spark Ethical Concerns In examining compensation records from drug companies to physicians who advised FDA on whether to approve 28 psychopharmacologic, arthritis, and cardiac or renal drugs between 2008 and 2014, Science found widespread after-the-fact payments or research support to panel members. The agency’s safeguards against potential conflicts of interest are not designed to prevent such future financial ties. [ScienceInsider] Editorial Hungarian Academy to Draw Up Alternative Research Budget The Hungarian Academy of Sciences is set to put forward an “alternative proposal” for the country’s research budget, after the government moved to put the Ministry of Innovation and Technology in charge of financing research institutions, seen as the latest attack on sector autonomy by the authoritarian Orbán administration. [Times Higher Education] Editorial
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EVENTSNEW World Muscle Society (WMS) Congress 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Associate – Muscle Cell Research (University of Louisville) Research Associate – Smooth Muscle Cells (University of Cambridge) Postdoctoral Fellow – Immunoengineering for Muscle Regeneration (Duke University) Postdoctoral Fellow – Cell-Based Cardiac Regeneration (Karolinska Institutet) Canada Excellence Research Chair – Cardiac Regeneration (University of Toronto) Senior Scientist/Scientist – Cardiac Differentiation and Cardiac Tissue Engineering (Novoheart) Postdoctoral Fellow – Human Skeletal Muscle Disease Modeling and Regeneration (Duke University) Postdoctoral Fellow – hiPSC Based Cardiac Regeneration (Duke University) Postdoctoral Fellow – Cardiovascular Tissue Engineering (Stanford University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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