Muscle Cell News 3.25 July 23, 2018 | |
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TOP STORYSilencing of THOC2 or THOC5 led to dedifferentiation of vascular smooth muscle cells (VSMCs) in vitro, characterized by decreased VSMC marker gene expression, and increased migration and proliferation. THOC2 and THOC5 physically interacted with and functionally relied upon each other to bind to specific motifs on VSMC marker gene mRNAs. [Circ Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSIn doxorubicin-treated cardiomyocytes, upregulation of miR-29b resulted in a significant decrease in Bax expression, with an increase in Bcl-2 expression, accompanied by inhibition of mitochondrial membrane depolarization, cytochrome c release, and caspase activation. [Cell Physiol Biochem] Full Article In isolated cardiocytes of hibernating ground squirrels generating stationary Ca2+ transients in the absence of actual myocellular excitation, low doses of this polyamine induced the Gβγ-dependent activation of PI3-kinase with subsequent stimulation of Akt-kinase and nitric oxide (NO) production by endothelial NO-synthase. [Cell Signal] Abstract | Graphical Abstract Rat neonatal cardiac myocytes were subjected to a hypoxia/reoxygenation procedure in vitro, which significantly decreased the cell viability, increased lactate dehydrogenase release, induced cardiomyocyte apoptosis, and increased [Ca2+]i. [Acta Pharmacol Sin] Abstract PARP1 Interacts with HMGB1 and Promotes Its Nuclear Export in Pathological Myocardial Hypertrophy Poly(ADP-ribose) polymerase 1 (PARP1) overexpression by infection with adenovirus PARP1 promoted the nuclear export of high-mobility group box 1 (HMGB1), facilitated its secretion outside the cell, and aggravated cardiomyocyte hypertrophy, which could be alleviated by HMGB1 overexpression. [Acta Pharmacol Sin] Abstract SKELETAL MUSCLE CELLSThe AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells AMPK activation or ectopic expression of a phosphomimetic p27Kip1 mutant was sufficient to suppress in vitro apoptosis, increase proliferation, and improve in vivo transplantation efficiency of aged skeletal muscle stem cells. [Stem Cell Reports] Full Article | Graphical Abstract Caveolae-Mediated Effects of TNF-α on Human Skeletal Muscle Cells Investigators demonstrated that TNF-α induced the formation of additional caveolae at the plasma membrane of myoblasts. TNF-α prevented myoblast fusion suggesting that inflammation could modulate caveolae organization/function and satellite cell function. [Exp Cell Res] Abstract Compared with the model group, chromium malate could significantly promote the secretion levels of GLUT-4, Akt, Irs-1, PPARγ, PI3K and p38-MAPK, promote AMPKβ1 phosphorylation, and reduced the level of p-Irs-1 in L6 cells with insulin resistance. [Biometals] Abstract | Graphical Abstract SMOOTH MUSCLE CELLSDefective Autophagy in Vascular Smooth Muscle Cells Enhances Cell Death and Atherosclerosis Vascular smooth muscle cells (SMCs) cultured from mice with SMC-specific deletion of the essential autophagy gene atg7 showed reduced serum-induced cell growth, increased cell death, and decreased cell proliferation rate. [Autophagy] Abstract Mir34a−/− smooth muscle cells (SMCs) were less prone to undergo senescence and under osteogenic conditions deposited less calcium compared with Mir34a+/+ cells. Unlike in Mir34a+/+ SMC, the known vascular calcification inhibitors SIRT1 and Axl were only partially downregulated in calcifying Mir34a−/− SMC. [Arterioscler Thromb Vasc Biol] Abstract Interaction between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure Scientists reported that Panx1 and Cav1 colocalized on the vascular smooth muscle cell plasma membrane of resistance arteries near sympathetic nerves in an adrenergic stimulus-dependent manner. Genetic deletion of Cav1 significantly blunted adrenergic-stimulated ATP release and vasoconstriction, with no direct influence on endothelium-dependent vasodilation or cardiac function. [Arterioscler Thromb Vasc Biol] Abstract Increased expression of microRNA-141, decreased expressions of RhoA and RhoA/Rho associated kinase 2 (mRNA and protein), accelerated cell proliferation rate and reduced cell apoptosis were found in the microRNA-141 mimics group and the siRNA-Rho group. [Cell Physiol Biochem] Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & ESC & iPSC News. | |
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REVIEWSBiomarkers for the Identification of Cardiac Fibroblast and Myofibroblast Cells The authors provide an outline of what is currently known about cardiac fibroblasts and myofibroblasts, the physiological and pathological roles within the heart, and causes for the transition of fibroblasts into myoblasts. [Heart Fail Rev] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSCARMELINA® (CArdiovascular safety and Renal Microvascular outcomE with LINAgliptin in patients with type 2 diabetes at high vascular risk) met its primary endpoint, defined as time to first occurrence of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, with Trajenta® demonstrating similar cardiovascular safety compared to placebo. [Boehringer Ingelheim International GmbH] Press Release UC San Diego Researchers Receive Funding to Pursue Novel Stem Cell-Based Treatments Proposed therapies would address a rare heart condition and a chronic lung disease. The first grant for almost $1.4 million was awarded to Eric Adler, MD, to pursue the use of genetically modified hematopoietic stem cells to treat Danon disease, a progressive condition characterized by weakening of the heart muscle, weakening of muscles used for movement and cognitive disability. [Regents of the University of California] Press Release Lawrence J. Ellison Institute for Transformative Medicine of USC Announces New Home in West L.A. The Ellison Institute’s new 79,000-sq. ft. building will house a cancer clinic, interdisciplinary research laboratories focused on scientific discovery and innovation, a think tank, community education and outreach, and a wellness program. It is slated to open in May 2019. [Lawrence J. Ellison Institute for Transformative Medicine (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSTrump and Brexit Could Lure More Scientists to Ireland, Says Research Chief Uncertainty in the UK and US scientific communities because of combined effects of Brexit and Donald Trump’s controversial policies could provide Ireland with a competitive advantage, according to the director general of Science Foundation Ireland. [The Irish Times] Editorial University of Edinburgh Demands Retraction of Researcher’s Papers The University of Edinburgh has asked for the retraction of five papers by cell biologist and former faculty member Irina Stancheva following an internal investigation into scientific misconduct allegations, according to Times Higher Education. [The Scientist] Editorial Dutch Publishing Giant Cuts Off Researchers in Germany and Sweden Elsevier stopped thousands of scientists in Germany from reading its recent journal articles, as a row escalates over the cost of a nationwide open-access agreement. The move comes weeks after researchers in Sweden lost access to the most recent Elsevier research papers, when negotiations on its contract broke down over the same issue. [Nature News] Editorial
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EVENTSNEW LabRoots: 6th Annual Cancer Research & Oncology Virtual Event Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Laboratory Research Scientist – Left Ventricle Heart Development (The Francis Crick Institute) Postdoctoral Position – BIH StemCell Techniques (Helmholtz Centre for Environmental Research) Postdoctoral Research Fellow – Cardiac Cells (University of British Columbia) Postdoctoral Associate – Muscle Cell Research (University of Louisville) Postdoctoral Fellow – Immunoengineering for Muscle Regeneration (Duke University) Postdoctoral Fellow – Cell-Based Cardiac Regeneration (Karolinska Institutet) Postdoctoral Fellow – Human Skeletal Muscle Disease Modeling and Regeneration (Duke University) Postdoctoral Fellow – hiPSC Based Cardiac Regeneration (Duke University) Postdoctoral Fellow – Cardiovascular Tissue Engineering (Stanford University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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