Muscle Cell News 3.36 October 29, 2018 | |
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TOP STORYScientists found that the secreted C1q-like1-4 proteins repressed fusion by specifically interacting with BAI3. They identified Stabilin-2 as a protein that interacted with BAI3 and stimulated its fusion promoting activity. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSHydrogen peroxide (H2O2) treatment significantly suppressed cell viability and increased cell apoptotic rate and caspase-3 activity in human cardiomyocytes (HCMs). Overexpression of SNHG1 attenuated the effects of H2O2 on HCMs viability and apoptosis; while SNHG1 exerted the opposite effects. [Cell Physiol Biochem] Full Article Researchers showed that doxorubicin (DOX) exposure provoked cardiac cyclin-dependent kinase 2 (CDK2) activation and cardiomyocyte cell cycle S-phase re-entry, resulting in enhanced cellular sensitivity to DOX. Genetic or pharmacological inhibition of CDK2 markedly suppressed DOX-induced cardiomyocyte apoptosis. Conversely, CDK2 overexpression augmented DOX-induced apoptosis. [J Biol Chem] Abstract | Full Article SKELETAL MUSCLE CELLSThe authors demonstrated that the decreased expression levels of mechanical unloading-induced muscle atrophy-related long noncoding RNA (lncMUMA) closely associated with a reduction of myogenesis during mechanical unloading. Mechanistically, lncMUMA promoted myogenic differentiation by functioning as a miR-762 sponge to regulate the core myogenic regulator MyoD in vitro. [Mol Ther] Full Article The exposure of murine skeletal muscle C2C12 cells to cigarette smoke extract significantly increased IL-8 and TNF-α levels as well as nuclear factor-κBp65 (NF-κBp65) mRNA and protein levels and NF-κBp65 activity. This effect was reversed by theophylline. Histone deacetylase 2 (HDAC2) knockdown enhanced the activity of NF-κBp65 and increased IL-8 and TNF-α levels in C2C12 cells. [Am J Physiol Lung Cell Mol Physiol] Abstract SMOOTH MUSCLE CELLSFMRP Recruitment of β-Catenin to the Translation Pre-Initiation Complex Represses Translation Investigators report novel components of the vascular smooth muscle cell β-catenin interactome. They revealed a basal recruitment of β-catenin to the messenger ribonucleoprotein and translational pre-initiation complex, fulfilling a translational repressor function. Wnt stimulation antagonized this function, in part, by sequestering β-catenin away from the pre-initiation complex. [EMBO Rep] Abstract | Graphical Abstract Paclitaxel+hirudin inhibited the levels of key proteins and the gene expression, except for that of the MyD88 gene, of the TLR4-MyD88 pathway. The trend of the effect of paclitaxel+hirudin on the pathway proteins was similar to that of MyD88 knockdown. [Cell Physiol Biochem] Full Article Scientists demonstrated that silencing ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) in vascular smooth muscle cells resulted in a tenfold increase in proliferation relative to that of cells transfected with negative control siRNA. The addition of recombinant human ENPP1-Fc, adenosine monophosphate (AMP) or adenosine restored the silenced ENPP1-associated proliferation. [Exp Mol Med] Full Article Overexpression of p53 in normal pulmonary arterial smooth muscle cells inhibited store-operated Ca2+ entry (SOCE) induced by passive depletion of intracellularly stored Ca2+ in the sarcoplasmic reticulum, while downregulation of p53 enhanced SOCE. [Am J Physiol Lung Cell Mol Physiol] Abstract Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating pERK1/2 Agonist-dependent inhibition of cell proliferation was found in human airway smooth muscle (HASM) cells derived from normal and asthmatic human lungs, as well as an immortalized HASM cell line. pERK1/2 downregulation was linked to downregulation of the upstream kinase MEK1/2. [Am J Respir Cell Mol Biol] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & ESC & iPSC News. | |
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REVIEWSAging-related low-grade inflammation is suggested to aggravate sarcopenia and frailty. The authors investigate the influence that drugs with anti-inflammatory effects have on inflammation and skeletal muscle. [Exp Gerontol] Abstract Cancer Cachexia: More Than Skeletal Muscle Wasting Investigators describe recent developments elucidating the roles of different tissues as well as tissue crosstalk in this wasting syndrome, including potential links to other cancer-associated morbidities. [Trends Cancer] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSMyoKardia, Inc. announced that patient dosing has begun in the MAVA Long-Term Extension (MAVA-LTE) clinical trial. The MAVA-LTE study will assess long-term safety of mavacamten, as well as its effects on symptoms and echocardiographic measures of systolic and diastolic cardiac function in patients with hypertrophic cardiomyopathy. [MyoKardia, Inc.] Press Release UC San Diego Signs MOU with Foundation for Biomedical Research and Innovation at Kobe The University of California San Diego and the Foundation for Biomedical Research and Innovation at Kobe have entered into a five-year memo of understanding (MOU). The five-year agreement seeks to promote cooperation and joint discovery in biomedical research. [Regents of the University of California] Press Release | |
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POLICY NEWSHeart Failure Stem Cell Trial to Be Paused after Calls for Retractions The National Institutes of Health will pause human testing of an experimental stem cell therapy for heart failure while a board charged with overseeing patient safety reviews the taxpayer-funded trial, in light of emerging questions about the scientific foundation for the treatment. [The Washington Post] Editorial ‘Tropical Trump’ Victory in Brazil Stuns Scientists Former military officer Jair Bolsonaro rode a wave of anti-establishment anger to victory in Brazil’s presidential election, leaving many researchers stunned and worried about the future of their country. [Nature News] Editorial What a Massive Database of Retracted Papers Reveals about Science Publishing’s ‘Death Penalty’ Nearly a decade ago, headlines highlighted a disturbing trend in science: The number of articles retracted by journals had increased 10-fold during the previous 10 years. Fraud accounted for some 60% of those retractions; one offender, anesthesiologist Joachim Boldt, had racked up almost 90 retractions after investigators concluded he had fabricated data and committed other ethical violations. [ScienceInsider] Editorial Font of Despair: In the Fierce Competition for Science Funding, Even a Typeface Glitch Can Be Fatal To those experienced in requesting cash from both the Department of Veterans Affairs and the National Institutes of Health, rejection on the basis of margin or serif, if not the most pressing problem in biomedical research, is unsurprising and frustrating. [STAT News] Editorial
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EVENTSNEW Keystone Symposia: Myeloid Cells Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Cardiomyocyte Mechanobiology (Queen Mary University of London) Postdoctoral Research Scientist – Integrative Cardiac Pathophysiology (Columbia University) Postdoctoral Associate Specialist – Muscle Aging Biology (Nestle Research – EPFL Campus) Faculty Position – Cardiovascular Diseases (Mayo Clinic) Postdoctoral Fellow – Cardiac Regeneration & Heart Failure (Icahn School of Medicine at Mount Sinai) Postdoctoral Fellow – Cardiovascular Biology (Weill Cornell Medicine) Postdoctoral Fellow – Cardiovascular Tissue Engineering (Stanford University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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