Muscle Cell News 4.01 January 14, 2019 | |
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TOP STORYScientists addressed the question about the physiological advantage of implementation of anoctamin 1 (ANO1) into the euteleost skeletal-muscle excitation-contraction coupling machinery. Their results revealed that Cl− influx through ANO1 played an essential role in restricting the width of skeletal-muscle action potentials by accelerating the repolarisation phase. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSDeletion of thrombospondins 3 (Thbs3) in mice enhanced integrin membrane expression and membrane stability, protecting the heart from disease stimuli. Researchers showed that mutating Thbs3 to contain the conserved RGD integrin binding domain normally found in Thbs4 and Thbs5 rescued the defective expression of integrins on the sarcolemma. [Nat Commun] Full Article Inhibition of Cardiomyocyte Sprouty1 Protects from Cardiac Ischemia-Reperfusion Injury Sprouty1-deficient cardiomyocytes showed better preserved mitochondrial membrane potential following ischemic injury and an increase in levels of phosphorylated extracellular signal-regulated kinase and phosphorylated glycogen synthase kinase-3β in mitochondria of hypoxic cardiomyocytes. [Basic Res Cardiol] Full Article The authors showed that the RIP3/p-MLKL necroptotic pathway and BNIP3-dependent apoptosis signaling are enhanced in H9c2 cells under hypoxic conditions, whereas compared with these pathways in the controls, those in miR-105-treated H9c2 cells are suppressed. [Mol Ther Nucleic Acids] Abstract | Full Article miR-375-3p knockdown reduced the surface area of primary cardiomyocytes increased by angiotensin II treatment and decreased the B-natriuretic peptide and β-myosin heavy chain mRNA and protein levels. miR-375-3p was also observed to directly target lactate dehydrogenase B. [J Cell Physiol] Abstract SKELETAL MUSCLE CELLSMyogenin Promoter-Associated lncRNA Myoparr Is Essential for Myogenic Differentiation Mechanistically, Myoparr interacted with Ddx17, a transcriptional coactivator of MyoD, and regulated the association between Ddx17 and the histone acetyltransferase PCAF. Myoparr also promoted skeletal muscle atrophy caused by denervation, and knockdown of Myoparr rescued muscle wasting in mice. [EMBO Rep] Abstract | Graphical Abstract Adiponectin Promotes Muscle Regeneration through Binding to T-Cadherin Purified high-molecular multimeric adiponectin accumulated intracellularly and colocalized with CD63-positive endosomes and enhanced exosome secretion in differentiating C2C12 myotubes but not in undifferentiated myoblasts. Knockdown of T-cadherin in differentiating C2C12 myotubes attenuated both adiponectin-accumulation and adiponectin-mediated exosome production. [Sci Rep] Full Article Rat H9c2 myoblasts were seeded into the 3D gelatin bubble-based scaffolds and compared to those grown on 2D gelatin-coating substrates to demonstrate the influences of spatial cues on cell behaviors. Relative to cells on the 2D substrates, the H9c2 myoblasts were featured by a good survival, normal mitochondrial activity, but slower cell proliferation within the 3D scaffolds. [Biotechnol Bioeng] Abstract SMOOTH MUSCLE CELLSToll-like receptor 2 (TLR2) deficiency suppressed TLR2 agonist-mediated vascular smooth muscle cell chondrogenic differentiation and consequent calcification, which were triggered via the concerted actions of interleukin 6 (IL-6)-mediated receptor activator of nuclear factor κB ligand (RANKL) induction and OPG suppression. [Arterioscler Thromb Vasc Biol] Abstract miRNA Let-7b Promotes the Development of Hypoxic Pulmonary Hypertension by Targeting ACE2 Investigators found that exposure to chronic hypoxia stimulated miRNA let-7b expression in rat lung via a HIF-1α dependent pathway. Let-7b downregulated angiotensin-converting enzyme 2 (ACE2) expression by directly targeting the coding sequence of ACE2. [Am J Physiol Lung Cell Mol Physiol] Abstract Calcium Sensing Receptor in Developing Human Airway Smooth Muscle Using cells from 18-22 week human fetal lungs, researchers tested the hypothesis that Ca2+ sensing receptor regulates intracellular Ca2+ in fetal airway smooth muscle. [J Cell Physiol] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & ESC & iPSC News. | |
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REVIEWSCatechins Enhance Skeletal Muscle Performance The authors review the functions and mechanisms of catechins in the differentiation of myogenic stem cells, biogenesis of mitochondria, synthesis and degradation of proteins, regulation of glucose level, and metabolism of lipids in muscle cells; and effect of catechins on the blood vessels, bones, and nerves that are closely related to skeletal muscles. [Crit Rev Food Sci Nutr] Abstract Regulation of Ribosome Biogenesis During Skeletal Muscle Hypertrophy Investigators review evidence demonstrating that transcription of ribosomal RNA genes is necessary for the increase in ribosomal capacity, and this is critical for muscle growth in human and animal models of hypertrophy. [Exerc Sport Sci Rev] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSTARA Biosystems and Insilico Medicine Announce Collaboration for Cardiac Disease Insilico Medicine announced the launch of a collaboration to discover and develop novel therapies for cardiac disease and diseases associated with cardiac muscle aging. [Insilico Medicine, Inc. (EurekAlert!)] Press Release Lupin announced that the European Commission has approved NaMuscla® for the symptomatic treatment of myotonia in adults with non-dystrophic myotonic disorders. Non-dystrophic myotonic disorders are a group of rare, inherited neuromuscular disorders which cause the inability to relax muscles following voluntary contraction. [Lupin] Press Release Pfizer Inc. announced that the FDA accepted for filing the company’s New Drug Applications (NDAs) for tafamidis for the treatment of transthyretin amyloid cardiomyopathy. Pfizer has submitted two NDAs based on two forms of tafamidis: meglumine salt and free acid. [Pfizer Inc.] Press Release Motor Neurone Disease Breakthrough: Patient Trial Shows Impressive Clinical Results A new drug developed by scientists at the Florey Institute of Neuroscience, and the School of Chemistry and Bio21 Institute at the University of Melbourne has dramatically improved clinical and cognitive symptoms of motor neurone disease, also called amyotrophic lateral sclerosis. [The University of Melbourne] Press Release | |
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POLICY NEWSOpen-Access Row Prompts Editorial Board of Elsevier Journal to Resign The editorial board of an influential scientometrics journal — the Journal of Informetrics — has resigned in protest over the open-access policies of its publisher, Elsevier, and launched a competing publication. [Nature News] Editorial If the Shutdown Drags on at FDA, It Will Put Anticipated New Treatments in Jeopardy The government shutdown could soon jeopardize highly anticipated new drugs from Janssen, Sanofi and Novartis for depression, diabetes and multiple sclerosis, as well as a host of other potential new therapies, according to a STAT analysis of upcoming regulatory decision dates. [STAT News] Editorial
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EVENTSNEW 2nd Annual Meeting of the American Society for Gene & Cell Therapy (ASGCT) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Positions – Cardiovascular Research (Ludwig-Maximilians-University in Munich) NEW Postdoctoral Position – Cardiomyocyte Mechanobiology (Queen Mary University of London) NEW Postdoctoral Research Position – Cardiovascular Medicine (University of California, Davis) Assistant Professor – Sarcoma & Skeletal-Related Malignancies (UC Davis School of Medicine) Scientist – Myotonic Dystrophy Type 1 Drug Discovery (Expansion Therapeutics, Inc.) Professor – Cardiovascular Research (The University of Tennessee Health Science Center) Assistant Professor Positions – Department of Cardiology (Boston Children’s Hospital) Postdoctoral Fellowship – Cardiovascular Sciences (Medical College of Wisconsin) Postdoctoral Research Fellow – Sarcopenia (Lee Kong Chian School of Medicine) Assistant/Associate Adjunct Professor – Cardiovascular Medicine (UC Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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