Muscle Cell News Volume 4.10 | Mar 25 2019

TOP STORY

Amphiphysin 2 Modulation Rescues Myotubular Myopathy and Prevents Focal Adhesion Defects in Mice

Researchers investigated the functional relationship between myotubularin and bridging integrator 1 (BIN1) in healthy skeletal muscle and in the physiopathology of centronuclear myopathy (CNM). Genetic overexpression of human BIN1 efficiently rescued the muscle weakness and life span in a mouse model of X-linked CNM. [Sci Transl Med] Abstract

(Ranked by impact factor of the journal)

CARDIAC MUSCLE CELLS

DNA Damage-Induced PARP1 Activation Confers Cardiomyocyte Dysfunction through NAD⁺ Depletion in Experimental Atrial Fibrillation

Scientists report that tachypacing-induced functional loss of atrial cardiomyocytes is precipitated by excessive poly(ADP)-ribose polymerase 1 (PARP1) activation in response to oxidative DNA damage. [Nat Commun] Full Article

Exosomes from Adipose-Derived Mesenchymal Stem Cells Prevent Cardiomyocyte Apoptosis Induced by Oxidative Stress

Investigators characterized exosomes from adipose-derived stem cells and evaluated their cardioprotective actions against ischemia reperfusion injury. [Cell Death Discov] Full Article

Induction of Cardiomyocyte-Like Cells from Hair Follicle Cells in Mice

Scientists demonstrated that hair follicle cells were able to be induced to differentiate into cardiomyocyte‑like cells in vitro under specific conditions. [Int J Mol Med] Abstract

SKELETAL MUSCLE CELLS

ZEB1 Protects Skeletal Muscle from Damage and Is Required for Its Regeneration

The authors report an unexpected role for ZEB1 regulating inflammatory and repair responses in dystrophic and acutely injured muscles. ZEB1 was upregulated in the undamaged and regenerating myofibers of injured muscles. [Nat Commun] Full Article

Single-Cell Analysis of Adult Skeletal Muscle Stem Cells in Homeostatic and Regenerative Conditions

Investigators compared the transcriptomes of thousands of muscle stem cells and primary myoblasts isolated from homeostatic or regenerating muscles by single-cell RNA-sequencing. [Development] Abstract

The DNA Methylation Status of Wnt and Tgfβ Signals Is a Key Factor on Functional Regulation of Skeletal Muscle Satellite Cell Development

Researchers systematically investigated the changes of genome-wide DNA methylation in satellite cells during skeletal muscle development. [Front Genet] Full Article

SMOOTH MUSCLE CELLS

Protective Role of RNA Helicase DEAD-Box Protein 5 in Smooth Muscle Cell Proliferation and Vascular Remodeling

Researchers showed that DEAD-box protein 5 was the most abundant DEAD-box protein expressed in human and rodent artery, which is mainly located in smooth muscle cells. [Circ Res] Abstract

Palmitate Decreases Migration and Proliferation and Increases Oxidative Stress and Inflammation in Smooth Muscle Cells. Role of the Nrf2 Signaling Pathway

Researchers showed that palmitate activates the transcription factor Nrf2 and the upstream kinases ERK1/2 and Akt in human coronary artery smooth muscle cells (HCASMCs). The inhibitor of Nrf2, trigonellin, significantly attenuated palmitate-induced HCASMC expression of the Nrf2 target gene NQO1. [Am J Physiol Cell Physiol] Abstract

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The Effect of Type 2 Diabetes Mellitus and Obesity on Muscle Progenitor Cell Function

A key component to the maintenance of skeletal muscle integrity and plasticity is the presence of muscle progenitor cells, including satellite cells, fibroadipogenic progenitors, and some interstitial progenitor cells associated with vessels. [Stem Cell Res Ther] Full Article

Visit our reviews page to see a complete list of reviews in the muscle cell research field.

Wave Life Sciences to Present Suvodirsen Phase I Safety and Tolerability Data and Phase II/III Clinical Trial Design

Wave Life Sciences Ltd. announced that four poster presentations highlighting new data and progress for its Duchenne muscular dystrophy (DMD) programs will be shared. [Press release from Wave Life Sciences Ltd. discussing research presented at the 2019 Muscular Dystrophy Association (MDA) Clinical and Scientific Conference, Orlando] Press Release

Amgen, Cytokinetics and Servier Announce Continuation of GALACTIC-HF Following Planned Interim Analysis

Amgen, Cytokinetics, Incorporated and Servier announced that the Data Monitoring Committee for GALACTIC-HF recently completed the first planned interim analysis, which included consideration of pre-specified criteria for futility. [Amgen Inc.] Press Release

Historic Partnership between the Weizmann Institute of Science and Institut Curie

The Weizmann Institute of Science in Rehovot, Israel, and Institut Curie in Paris, France, signed a historic partnership that will allow their teams to work closely together to improve knowledge in the field of life sciences, particularly in the areas of physics and chemistry, and most specifically, in the field of cancer research. [Weizmann Institute of Science] Press Release

Scientists among Thousands Marching to Demand Say on Brexit

Scientists took to the streets of London on 23 March as part of a major demonstration calling for the terms of Brexit to be put to the British people in a vote. [Nature News] Editorial

Chinese-American Scientist Societies Fear Racial Profiling

In a strongly worded letter published in Science, a group of Chinese-American scientists voiced concern that recent proposals from the National Institutes of Health and FBI actions could lead to unjust targeting of ethnically Chinese scientists. [The Scientist] Editorial

NEW 2019 Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress
May 27-31, 2019
Rhodes, Greece

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Scholar – Cardiovascular Genomics (Stanford Medicine)

Early Stage Researchers – Various (Institutions across Europe in the TRIM-NET – ITN Network)

Postdoctoral Research Associate – Cardiovascular Research (Old Dominion University)

Postdoctoral Position – Mechanotransduction in Heart Development and Regeneration (Brown University)

Assistant Professor – Sarcoma or Skeletal Related Malignancies (University of California, Davis)

Postdoctoral Position – Muscle Stem Cell Biology (University of Sherbrooke)

Postdoctoral Fellow – Stem Cells & Cardiac Regeneration (Temple University)

Assistant Specialist – Cardiovascular Research (University of California, Davis)

Postdoctoral Research Associate – Cardiac Stem Cells (University of Louisville)

Postdoctoral Position – Cardiomyopathy (University of Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute)

Postdoctoral Research Position – Cardiovascular Medicine (University of California, Davis)

Assistant/Associate Adjunct Professor – Cardiovascular Medicine (University of California, Davis)

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