Muscle Cell News 5.00 January 6, 2020 | |
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TOP STORYArterial Sca1+ Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration The authors performed cell fate mapping and single-cell RNA sequencing to identify Sca1+ vascular stem cells (VSCs) in the adventitial layer of artery walls. After severe injury, Sca1+ VSCs migrated into the medial layer and generated de novo smooth muscle cells, which subsequently expanded more efficiently compared with pre-existing smooth muscle. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSResearchers uncovered that proliferating border zone cardiomyocytes had very distinct transcriptomes compared to the nonproliferating remote cardiomyocytes and that they resembled embryonic cardiomyocytes. [eLife] Abstract Scientists showed that Rb1 abolished high calcium-induced delayed afterdepolarizations, depressed the increase in intracellular calcium, relieved calcium overload and protected cardiomyocytes. [Sci Rep] Full Article SKELETAL MUSCLE CELLSThanks to the compartmentalization of fish muscle fibers the authors developed a slow myoblast cell culture for rainbow trout. Slow and fast muscle-derived myoblasts had similar morphology, but with differential expression of slow muscle markers such as slow myhc, sox6 and pgc-1α. [J Exp Biol] Abstract Investigators established three cell pools consisting of M. rhomboideus or M. longissimus from ten or six piglets, each with one gender and medium birth weight. Real-time impedimetric monitoring was used to evaluate the proliferative growth behavior of myoblasts for the cell pools in comparison to their corresponding unpooled cells over a period of 72 hours, with a measurement being taken every 30 minutes. [In Vitro Cell Dev Biol Anim] Full Article SMOOTH MUSCLE CELLSIn cell culture and in rat carotid arterial injury models, specificity protein 1 (Sp‐1) expression was significantly induced, and correlated with smooth muscle cell proliferative phenotype. [J Am Heart Assoc] Full Article The authors investigated the benefits of melatonin in asthma, with an emphasis on airway remodeling. The results indicated that melatonin significantly attenuated airway hyperresponsiveness, inflammation and remodeling in a house dust mite model. [Cell Tissue Res] Abstract Scientists detected pyruvate kinase isoform M2 (PKM2) expression and pyruvate kinase activity in oxidized low-density lipoprotein (oxLDL)-treated vascular smooth muscle cells (VSMCs) and explored the regulation of PKM2 in oxLDL-treated VSMCs and apoE−/− mice. [Acta Biochim Biophys Sin] Abstract Researchers examined the effects of plasma small extracellular vesicles in Wistar Kyoto rats and spontaneously hypertensive rats on the proliferative and migratory functions of primary rat aortic smooth muscle cells. [J Vet Med Sci] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & ESC & iPSC News. | |
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REVIEWSThe authors summarize and discuss the effects of iron overload on cardiac mitochondrial function, cardiac mitochondrial dynamics, ferroptosis of cardiomyocytes, and left ventricular function in in vitro and in vivo reports. [Arch Biochem Biophys] Abstract | Graphical Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSSarepta Therapeutics, Inc. announced that Sarepta and Roche have entered into a licensing agreement providing Roche exclusive commercial rights to SRP-9001, Sarepta’s investigational gene therapy for Duchenne muscular dystrophy, outside the United States. [Sarepta Therapeutics, Inc.] Press Release Cytokinetics Announces Start of Redwood-HCM, a Phase II Clinical Trial of CK-3773274 Cytokinetics, Incorporated announced that REDWOOD-HCM (Randomized Evaluation of Dosing With CK-274 in Obstructive Outflow Disease in HCM) has opened to enrollment. REDWOOD-HCM is a Phase II clinical trial of CK-3773274, a next-generation cardiac myosin inhibitor discovered by company scientists, which Cytokinetics is developing for the potential treatment of hypertrophic cardiomyopathy. [Cytokinetics, Incorporated] Press Release | |
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POLICY NEWSA Year After the Midterm Elections, Where Are They Now? November 2018 saw a wave of candidates from all walks of science-engineering, physics, medicine, and other life sciences-win first-time positions in the House, Senate, and state legislatures across the country. Of 20 STEM candidates running for Congressional seats that The Scientist counted last year, 10 won their races, the vast majority of them Democrats as well as political newcomers. [The Scientist] Editorial
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EVENTSNEW FEBS3+ Life Sciences Switzerland Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Doctoral Student – Biomedical Sciences (Linnaeus University) NEW PhD Student – Aortic Disease (University Hospital of Cologne) Postdoctoral Fellow – Computation Systems and Skeletal Muscles (University of Luxembourg) Postdoctoral Researcher – Muscle Stem Cell Biology (University at Albany) Postdoctoral Researcher – Skeletal Muscle Aging (St. Jude Children’s Research Hospital) Senior Scientist – Muscle Cell Biology (Shape Therapeutics) Asistant Professor – Ion Channels (University of Tennessee) Assistant Professor – Muscle Biology (Purdue University) Postdoctoral Researcher – Genome Editing in Cardiac Microtissues (The Jackson Laboratory) Assistant Specialist – Cardiovascular Medicine (University of California, Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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