Muscle Cell News 5.09 March 16, 2020 | |
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TOP STORYScientists developed an extracellular nanovesicle-based ribonucleoprotein delivery system named NanoMEDIC by utilizing two distinct homing mechanisms. NanoMEDIC achieved over 90% exon skipping efficiencies in skeletal muscle cells derived from Duchenne muscular dystrophy patient induced pluripotent stem cells. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSResearchers found that hyperglycemia induced oxidative stress and increased cell death by promoting pyroptosis and apoptosis in human cardiac stem cells, which was prevented in matrix metalloproteinase-9 (MMP9)−/− human cardiac stem cells. [Cell Death Dis] Full Article Investigators describe a simple device in modified culture plate on which human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes could form 3D self-organized tissue rings. [Commun Biol] Full Article Cardiopoietic Stem Cell Therapy Restores Infarction-Altered Cardiac Proteome Cell therapy non-stochastically reversed a majority of infarction-provoked changes, remediating 85% of disease-affected protein clusters. Pathway and network analysis decoded functional reorganization, distinguished by prioritization of vasculogenesis, cardiac development, organ regeneration, and differentiation. [NPJ Regen Med] Full Article | Press Release SKELETAL MUSCLE CELLSCRISPR/Cas9 Mediated miR-29b Editing as a Treatment of Different Types of Muscle Atrophy in Mice In vivo, CRISPR-based treatment prevented the muscle atrophy induced by angiotensin II (AngII), immobilization and denervation via activation of AKT-FOXO3A-mTOR signaling pathway and protected against AngII-induced myocyte apoptosis in mice, leading to significantly increased exercise capacity. [Mol Ther] Abstract | Graphical Abstract | Full Article Researchers showed that myogenic stem/progenitor cells exhibited heterogeneous expression of multiple syndecan proteins in cycling myogenic cells, suggesting that syndecans may coordinate myogenic fate regulation. [Cell Rep] Full Article | Press Release | Graphical Abstract Dynamics of Asymmetric and Symmetric Divisions of Muscle Stem Cells In Vivo and on Artificial Niches Scientists generated SNAP-tagged histone H3-reporter mice and found that, unlike fly germline stem cells, differential fate outcomes were associated with a symmetric distribution of the H3.1 and H3.3 histone variants in mouse muscle stem cells. [Cell Rep] Full Article | Graphical Abstract In in vitro experiments, the authors demonstrated that while both primary myoblasts and myocytes presented the antigen to GFP-specific T cells through MHC-I, myoblasts were more resistant to Fas-dependent CTL killing activity. [Mol Ther Methods Clin Dev] Abstract | Graphical Abstract | Full Article Co-Inhibition of BET Proteins and PI3Kα Triggers Mitochondrial Apoptosis in Rhabdomyosarcoma Cells The authors identified a novel synergistic interaction of the bromodomain and extraterminal (BET) inhibitor JQ1 with the PI3Kα-specific inhibitor BYL719 to trigger mitochondrial apoptosis and to suppress tumor growth in models of rhabdomyosarcoma. [Oncogene] Abstract Meteorin-Like Facilitates Skeletal Muscle Repair through a Stat3/IGF-1 Mechanism Mice genetically lacking meteorin-like had impaired muscle regeneration associated with a reduction in immune cell infiltration and an inability to transition towards an anti-inflammatory phenotype. [Nat Metab] Full Article SMOOTH MUSCLE CELLSRole of Isocitrate Dehydrogenase 2 on DNA Hydroxymethylation in Human Airway Smooth Muscle Cells Inhibition of isocitrate dehydrogenase 2 in asthmatic airway smooth muscle (ASM) cells decreased the α-ketoglutarate level, ten-eleven translocation activity, and global DNA hydroxymethylation and reversed the aberrant ASM phenotypes. [Am J Respir Cell Mol Biol] Abstract Treatment with the Trx1-specific inhibitor PX-12 significantly reduced pulmonary arterial pressure and vascular remodeling, as well as improved in vivo cardiac function and right ventricular hypertrophy, in Su/Hox-induced pulmonary arterial hypertension rats. [Exp Cell Res] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & ESC & iPSC News. | |
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REVIEWSThe Regulatory Role of Melatonin in Skeletal Muscle Scientists outline the latest research on the involvement of melatonin in the regulation of muscle development and regeneration in order to better understand its underlying molecular mechanisms and potential applications. [J Muscle Res Cell Motil] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSFDA Inks Research Collaboration Agreement with AnaBios Focused on Human Primary Cardiomyocytes AnaBios announced a Research Collaboration Agreement with the FDA to study adult human primary cardiomyocytes as a reference for cellular properties and drug-induced effects on cardiac function. [AnaBios] Press Release Acceleron Pharma Inc. announced that treatment with ACE-083 in patients with Charcot-Marie-Tooth disease did not demonstrate functional improvement in the Phase II trial. [Acceleron Pharma Inc.] Press Release | |
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POLICY NEWSUK Government to Boost R&D Spending The British government has announced a 15 percent increase in public funding for research and development as part of its 2020 budget in a move that was generally welcomed by scientists. [The Scientist] Editorial Universities Are Forging Ties with the FBI as US Cracks Down on Foreign Influence US universities are forging closer ties with FBI agents, encouraging scientists to disclose foreign sources of research funding, and tightening restrictions on researchers’ travel. [Nature News] Editorial
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EVENTSNEW EMBO Workshop: Neuroepigenetics – From Cells to Behaviour and Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Candidate – Muscle Research (Hannover Medical School) Postdoctoral Fellow – Disuse Atrophy (University of Illinois) Postdoctoral Researcher – Soft Tissue Biology (Mayo Clinic) Postdoctoral Fellow – Neuromuscular Disease (Johns Hopkins Medicine) Postdoctoral Fellow – Vascular Biology (Augusta University) Postdoctoral Position – Molecular Skeletal Muscle Cell Signaling (University of Copenhagen) Postdoctoral Fellow – Cardiac Tissue Engineering and Regeneration (Duke University) Postdoctoral Research Associate – Muscle Stem Cell Biology (State University of New York) Assistant Specialist – Cardiovascular Medicine (University of California, Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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