Muscle Cell News 5.13 April 13, 2020 | |
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TOP STORYResearchers developed an off-the-shelf therapeutic cardiac patch composed of a decellularized porcine myocardial extracellular matrix scaffold and synthetic cardiac stromal cells generated by encapsulating secreted factors from isolated human cardiac stromal cells. [Sci Transl Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSUsing cardiac stem cells expressing plasma membrane reporters, extracellular vesicles of W8B2+ cardiac stem cells were found to be transferred to the heart and other organs at four weeks post-implantation. [Cardiovasc Res] Abstract | Graphical Abstract The authors evaluated the effect of mammalian target of rapamycin (mTOR) inhibition by rapamycin on the cellular function of human cardiac progenitor cells and discovered that treatment with rapamycin markedly attenuated replicative cell senescence in human cardiac progenitor cells and promoted their cellular functions. [Exp Mol Med] Full Article Human Cardiac Organoids for the Modelling of Myocardial Infarction and Drug Cardiotoxicity The authors showed that cardiac organoids that incorporated an oxygen-diffusion gradient and that were stimulated with the neurotransmitter noradrenaline model the structure of the human heart after myocardial infarction. [Nat Biomed Eng] Abstract Researchers investigated cardiomyopathy resulted from the programmed cell death-1 (PD-1)/programmed cell death ligand-1 axis blockade using the anti-PD-1 antibody in embryonic stem cells-derived cardiomyocytes and a melanoma tumor-bearing murine model. [Int J Mol Sci] Full Article SKELETAL MUSCLE CELLSSynaptic Silencing of Fast Muscle Is Compensated by Rewired Innervation of Slow Muscle By generating mutant zebrafish whose fast muscles were synaptically silenced, scientists examined the contribution of fast muscles in both larval and adult zebrafish. [Sci Adv] Full Article Mechanism of Actin N-Terminal Acetylation Investigators showed that NAA80 did not associate with filamentous actin in cells, and its natural substrate was the monomeric actin-profilin complex, consistent with amino-terminal-acetylation preceding polymerization. [Sci Adv] Full Article Muscle tissues as well as isolated myogenic cells of four-day-old German Landrace piglets were analyzed. Two heterogeneous satellite cell subpopulations, which contributed differently to muscle development, were isolated from low birth weight pigs by Percoll density gradient centrifugation. [Sci Rep] Full Article The authors investigated the effects of extracellular matrix and supplementation of a small molecule, which has been reported to enhance α7β1 integrin expression, on cell migration speed, cell fusion rate, myoblast differentiation and contractile force generation of tissue-engineered artificial skeletal muscles. [J Biosci Bioeng] Abstract Researchers showed that exercise in the form of voluntary wheel running accelerated muscle repair in old mice and improved old muscle stem cell function. [Nat Metab] Abstract | Press Release SMOOTH MUSCLE CELLSSurface topographies were not associated with a clear orientation or elongation of vascular smooth muscle cells. The number of cells was increased on wrinkled surfaces compared with that on other surfaces, contributing to continuously increased cell proliferation. [Biochem Biophys Res Commun] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & ESC & iPSC News. | |
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REVIEWSMechanobiology Assays with Applications in Cardiomyocyte Biology and Cardiotoxicity The authors provide a brief overview of techniques that can be used to quantify changes in the active force that cardiomyocytes generate and variations in their inherent stiffness in response to cardiotoxic drugs. [Adv Healthc Mater] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSHospital Gets €6 Million Research Grants Catharina Hospital has received two research grants with each worth €3 million. The hospital will use the grants in the areas of bowel cancer and cardiovascular disease. Catharina Hospital is an international leader in these two areas. [Catharina Hospital (Eindhoven News)] Press Release | |
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POLICY NEWSAfter Claims of Sex Bias, Scientific Leader at NIH’s Child Health Institute Withdraws from New Job Constantine Stratakis, the geneticist who directed intramural science at the National Institute of Child Health and Human Development for the past decade, withdrew today from a position he was slated to take in June as executive director and chief scientific officer of the Research Institute of the McGill University Health Centre in Montreal, Canada. [ScienceInsider] Editorial President of Europe’s Premier Science Funder Resigns amid Criticism That He Neglected Post The president of Europe’s most prestigious funding agency has resigned suddenly after only three months in the post – prompting fiery accusations from the organization’s governing body that he largely neglected his responsibilities. [Nature News] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Fellow – Therapy for Cardiovascular Disease (University of Iowa) Professor – Molecular Physiology (Karolinska Institutet) Postdoctoral Fellow – NAD Metabolism in Heart Disease (Oklahoma Medical Research Foundation) Associate Professor – Cancer Biology (University of Cincinnati) Group Leader – Cancer Biology (Institute of Pharmacology and Structural Biology) Postdoctoral Researcher – Soft Tissue Biology (Mayo Clinic) Postdoctoral Fellow – Cardiac Tissue Engineering and Regeneration (Duke University) Postdoctoral Research Associate – Muscle Stem Cell Biology (State University of New York) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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