 | | Vol. 5.21 – 15 June, 2020 |
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| Scientists found that SHANK3 localized in Z-discs in the skeletal muscle sarcomere and co-immunoprecipitated with α-ACTININ.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers used acellular biologic extracellular matrix scaffolds (bioscaffolds) to stimulate pathways of muscle repair and restore tissue function. They showed that acellular bioscaffolds with bioinductive properties can redirect cardiac fibroblasts to rebuild microvascular networks and avoid tissue fibrosis.
[Scientific Reports] |
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| Neurons were individually induced, facilitating the regulation of the beating rates of hiPSC-derived cardiomyocytes in an antagonistic manner.
[Scientific Reports] |
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| Overexpression of divalent metal transporter 1 (DMT1) promoted H/R-induced myocardial cell ferroptosis, while knockdown of DMT1 significantly inhibited the ferroptosis.
[Cell Biology and Toxicology] |
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| In cells, phosphorylation of Y155, or its phospho-mimetic mutation, prevented the interaction of regulatory light chain with the myosin heavy chain to form functional non-muscle myosin II units.
[Current Biology] |
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| Cultivation of myogenic progenitor cells in smooth muscle differentiation medium significantly increased the fraction of alpha smooth muscle actin and smoothelin-positive cells, while leaving the number of desmin-positive cells unchanged.
[Stem Cell Research & Therapy] |
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| In vitro phenotypic modulation of vascular smooth muscle cells (VSMC) was associated to an increased functional expression of Kv1.3 channels, and only selective Kv1.3 channel blockers were able to inhibit porcine VSMC proliferation.
[Translational Research] |
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| Knocking down insulin‐like growth factor binding protein 6 in vascular smooth muscle cells significantly attenuated cell proliferation and induced the S phase arrest during the cell cycle.
[Journal of Cellular Physiology] |
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| Pretreatment with autophagy activator rapamycin and AMPK activator AICAR both upregulated the autophagy level and downregulated the effects of advanced glycation end-products on osteoblastic differentiation of vascular smooth muscle cells.
[Molecular and Cellular Biochemistry] |
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| B cells produce antibodies that interfere with cardiomyocyte function, which culminates as the result of recruitment and activation of a variety of innate and structural cell populations, including neutrophils, macrophages, fibroblasts, and T cells.
[ESC Heart Failure] |
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| Sarepta Therapeutics announced positive results from a study of SRP-9003, its investigational gene therapy for limb-girdle muscular dystrophy Type 2E.
[Sarepta Therapeutics] |
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| The FDA revoked its emergency use authorization for hydroxychloroquine sulfate and chloroquine phosphate to treat COVID-19.
[ScienceInsider] |
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| China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
[Nature News] |
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| 2020-06-22 – 2020-06-24
Virtual |
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| | University of Miami Health System – Miami, United States |
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| | Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| | Berlin School of Integrative Oncology – Berlin, Germany |
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| | University of California, Davis – Davis, California, United States |
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| | Spanish National Center for Cardiovascular Research – Madrid, Spain |
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| | Stanford University School of Medicine – Stanford, California, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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