 | | Vol. 5.22 – 22 June, 2020 |
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| In vitro cultures of synthetic vascular smooth muscle cells (VSMCs) showed decreased expression of contractile markers CNN1, αSMA and SM22α and an increase in synthetic marker S100A4 compared to contractile VSMCs.
[Circulation Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Direct co-culture with postnatal cardiac fibroblasts increased cardiomyocyte binucleation, which could be inhibited by RGD peptide treatment.
[Circulation Research] |
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| The expression of LINC00261 was significantly down-regulated in myocardial tissues and H9C2 cells. Overexpression of LINC00261 improved cardiac function and reduced myocardium apoptosis.
[Journal of Cellular and Molecular Medicine] |
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| Researchers present a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits.
[Molecular Therapy-Methods & Clinical Development] |
| | Investigators found that protein and mRNA expression levels of PHD finger protein 20 (PHF20) were decreased during myogenic differentiation in C2C12 cells.
[Cell Death & Differentiation] |
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| The authors found that rexinoid x receptor signaling associated with the distribution of myogenin at poised enhancers and a distinct E-box motif. They also found an association of myogenin with rexinoid-responsive gene expression and identified an epigenetic signature related to histone acetyltransferase p300.
[Communications Biology] |
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| Scientists showed a significant enrichment of mitochondrial membrane proteins among proteins showing altered expression in Zbed6−/− myoblasts.
[FASEB Journal] |
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| Scientists used multicolor lineage-tracing models to confirm that the mature smooth muscle cell could give rise to a hyperproliferative cell which appeared to promote inflammation via elaboration of complement-dependent anaphylatoxins.
[Proceedings of the National Academy of Sciences of the United States of America] |
| | In human aortic smooth muscle cells, diphenylthiourea caused membrane hyperpolarization, mediated by activation of KATP and Kv7 potassium channels.
[Pharmacological Research] |
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| The effects of dysregulated ladybird homeobox 2 antisense RNA 1 or ladybird homeobox 2 on vascular smooth muscle cell biological processes were surveyed via cell counting kit-8, methyl thiazolyl tetrazolium, terminal-deoxynucleoitidyl transferase mediated nick end labeling and caspase-3 activity assays.
[Biomedicine & PharmacoTherapy] |
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| The authors focus on the mechanisms that regulate ryanodine receptor 2 (RYR2), the major sarcoplasmic reticulum Ca2+-release channel in the heart, and how RYR2 becomes dysfunctional in heart failure and atrial fibrillation.
[Nature Reviews Cardiology] |
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| Sarepta Therapeutics, Inc. and Selecta Biosciences, Inc. announced that they have entered into a research license and option agreement granting Sarepta an option to license the rights to develop and commercialize Selecta’s immune tolerance platform for use in Duchenne muscular dystrophy and certain limb-girdle muscular dystrophies.
[Sarepta Therapeutics, Inc.] |
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| Sarepta Therapeutics, Inc. and Codiak BioSciences, Inc. announced a global research and option agreement to design and develop engineered exosome therapeutics to deliver gene therapy, gene editing and RNA technologies for neuromuscular diseases.
[Sarepta Therapeutics, Inc.] |
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| A bipartisan group of US senators proposed sweeping—and controversial—changes in how the federal government manages academic research in the face of threats from other countries.
[ScienceInsider] |
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| 2020-10-04 – 2020-10-07
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| | Northwestern University – Chicago, Illinois, United States |
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| | University of Miami Health System – Miami, United States |
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| | Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| | Berlin School of Integrative Oncology – Berlin, Germany |
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| | University of California, Davis – Davis, California, United States |
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| | Stanford University School of Medicine – Stanford, California, United States |
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| | Spanish National Center for Cardiovascular Research – Madrid, Spain |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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