 | | Vol. 5.23 – 29 June, 2020 |
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| Investigators identified a rare subset of muscle cells concentrated at two precise anatomical locations and in tight association with photoreceptor axons.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) from individuals who experienced doxorubicin-induced cardiotoxicity (DIC) showed significantly greater sensitivity to doxorubicin compared to iPSC-CMs from doxorubicin-treated individuals who did not develop DIC in cell viability and optical mapping experiments.
[Scientific Reports] |
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| The authors showed that KPP regulated cardiomyocyte proteins associated with, but not limited to, apoptosis, muscle contraction, protein turnover, and the respiratory chain.
[Journal of Proteome Research] |
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| Investigators developed pre-innervated tissue-engineered muscle comprised of long aligned networks of spinal motor neurons and skeletal myocytes on aligned nanofibrous scaffolds.
[Communications Biology] |
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| Scientists analyzed the level of calpain pathway members in mice and human cellular spinal muscular atrophy models. They indicated an increase of calpain activity in survival motor neuron-reduced motoneurons.
[Cell Death & Disease] |
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| Abscisic acid (ABA) increased expression of important glycogen synthase, glucose, fatty acid and mitochondrial metabolism genes and increased direct measures of fatty acid oxidation, glucose oxidation and metabolic flexibility in soleus muscle cells from ABA-treated mice with diet-induced obesity.
[Scientific Reports] |
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| Researchers established the adenine-induced chronic renal failure (CRF) rat model and in vitro vascular calcification (VC) models based on vascular smooth muscle cells to examine histone deacetylase/lysine demethylase 1A/SESN2 as a novel molecular pathway in CRF-induced VC.
[Journal of Cellular and Molecular Medicine] |
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| Scientists investigated the function of transient receptor potential mucolipin 1 (TRPML1) channels in fully differentiated contractile vascular smooth muscle cells.
[Science Signaling] |
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| Scientists describe the latest advances in the understanding of the processes involved in coronary vessel formation, with mechanistic insights taken from developmental studies.
[Nature Reviews Cardiology] |
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Further understanding of key metabolic factors driving cardiac maturation will facilitate the generation of more mature human pluripotent stem cell-derived cardiomyocyte models.
[Current Cardiology Reports] |
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| PeerWell announces a new partnership with comprehensive risk management innovator, CorVel Corporation. Together, CorVel and PeerWell will offer cutting-edge remote care solutions to thousands of injured workers.
[PeerWell] |
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| On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News] |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States | |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | Spanish National Center for Cardiovascular Research – Madrid, Spain |
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| | University of California, Davis – Davis, California, United States |
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| | Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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