Muscle Cell News Volume 5.25 | Jul 13 2020

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    MUSCN 5.25 | July 13 2020


    Muscle Cell News by STEMCELL Technologies
    Vol. 5.25 – 13 July, 2020
    TOP STORY

    Targeting Muscle-Enriched Long Non-Coding RNA H19 Reverses Pathological Cardiac Hypertrophy

    Vector-based, cardiomyocyte-directed gene therapy using murine and human H19 strongly attenuated heart failure even when cardiac hypertrophy was already established.
    [European Heart Journal]

    Full Article

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    Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes

    Researchers demonstrated massive expansion of human induced pluripotent stem cell-derived cardiomyocytes in vitro by glycogen synthase kinase-3β inhibition using CHIR99021 and concurrent removal of cell-cell contact.
    [Cell Stem Cell]

    Abstract

    Anti-Integrin αV Therapy Improves Cardiac Fibrosis after Myocardial Infarction by Blunting Cardiac PW1+ Stromal Cells

    Scientists used transcriptomic and proteomic approaches to identify specific cell-surface markers for cardiac PW1+ cells and found that αV-integrin was expressed in almost all cardiac PW1+ cells, predominantly as the αVβ1 complex.
    [Scientific Reports]

    Full Article

    Suppression of Sox4 Protects against Myocardial Ischemic Injury by Reduction of Cardiac Apoptosis in Mice

    Overexpression of Sox4 promoted cardiomyocyte apoptosis with or without H2O2, whereas knocking down of Sox4 alleviated H2O2‐induced apoptosis in cardiomyocytes.
    [Journal of Cellular Physiology]

    Abstract

    GRP78 Effectively Protect Hypoxia/Reperfusion-Induced Myocardial Apoptosis via Promotion of the Nrf2/HO-1 Signaling Pathway

    Scientists explored the effects of GRP78 on hypoxia/reperfusion (H/R)-induced cardiomyocyte injury.They observed that GRP78 overexpression significantly protected myocytes from H/R-induced apoptosis.
    [Journal of Cellular Physiology]

    Full Article

    Single-Cell Deconstruction of Post-Sepsis Skeletal Muscle and Adipose Tissue Microenvironments

    In skeletal muscle, scRNA‐seq analysis classified 1438 single cells into myocytes, endothelial cells, fibroblasts, mesenchymal stem cells, macrophages, neutrophils, T‐cells, B‐cells, and dendritic cells.
    [Journal of Cachexia Sarcopenia and Muscle]

    Abstract

    AChR Antibodies Show a Complex Interaction with Human Skeletal Muscle Cells in a Transcriptomic Study

    Researchers explored the effects of acetylcholine receptor (AChR) antibodies binding to mature human myotubes with agrin-induced AChR clusters and pathways relevant for AChR degradation using bulk RNA sequencing.
    [Scientific Reports]

    Full Article

    Focal Adhesion Displacement Magnitude Is a Unifying Feature of Tensional Homeostasis

    Micropattern traction microscopy was used to study a wide range of focal adhesion traction forces generated by bovine vascular smooth muscle cells and bovine aortic endothelial cells cultured on substrates of stiffness of 3.6, 6.7, 13.6, and 30 kPa.
    [Acta Biomaterialia]

    Abstract

    A Multi-Layered Scaffold for Regeneration of Smooth Muscle and Connective Tissue Layers

    Researchers showed that within a single scaffold, the architecture supported alignment of contractile smooth muscle cells and deposition by fibroblasts of a meshwork of extracellular matrix fibrils.
    [Journal of Biomedical Materials Research Part A]

    Abstract


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    REVIEWS

    Sclerostin and Vascular Pathophysiology

    Sclerostin is becoming a marker for clinical and subclinical vascular diseases and several lines of evidence illustrate its role in the pathophysiology of the vascular system.
    [International Journal of Molecular Sciences]

    Full Article

    INDUSTRY AND POLICY NEWS

    ‘I Feel Like I Am Not Welcome’: Medical, Doctoral Students from Abroad Grapple with Uncertainty from New ICE Rules

    International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country.
    [STAT News]

    Editorial

    ‘Disturbing and Cruel.’ Universities Blast New Visa Rule for International Students

    A new US immigration policy, which threatens to revoke visas for certain international students if they are not taking in-person classes, is stirring panic and confusion and causing some universities to push back with lawsuits.
    [Science]

    Editorial

    FEATURED EVENT

    2020 Parenteral Drug Association (PDA) Annual Meeting

    July 20 – July 22
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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cardiac Regeneration

    Duke University – Durham, North Carolina, United States

    In Vitro Scientist – Atherosclerosis and Cardiovascular Research

    Novo Nordisk A/S – Måløv, Denmark

    Postdoc Position – Cardiovascular Research

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Researcher/Surgery – Muscle Fibrosis

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Fellow – Aging Muscle

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    > See All Jobs

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