| Vol. 5.25 – 13 July, 2020 |
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| Vector-based, cardiomyocyte-directed gene therapy using murine and human H19 strongly attenuated heart failure even when cardiac hypertrophy was already established. [European Heart Journal] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated massive expansion of human induced pluripotent stem cell-derived cardiomyocytes in vitro by glycogen synthase kinase-3β inhibition using CHIR99021 and concurrent removal of cell-cell contact. [Cell Stem Cell] |
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| Scientists used transcriptomic and proteomic approaches to identify specific cell-surface markers for cardiac PW1+ cells and found that αV-integrin was expressed in almost all cardiac PW1+ cells, predominantly as the αVβ1 complex. [Scientific Reports] |
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| Overexpression of Sox4 promoted cardiomyocyte apoptosis with or without H2O2, whereas knocking down of Sox4 alleviated H2O2‐induced apoptosis in cardiomyocytes. [Journal of Cellular Physiology] |
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| Scientists explored the effects of GRP78 on hypoxia/reperfusion (H/R)-induced cardiomyocyte injury.They observed that GRP78 overexpression significantly protected myocytes from H/R-induced apoptosis. [Journal of Cellular Physiology] |
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| In skeletal muscle, scRNA‐seq analysis classified 1438 single cells into myocytes, endothelial cells, fibroblasts, mesenchymal stem cells, macrophages, neutrophils, T‐cells, B‐cells, and dendritic cells. [Journal of Cachexia Sarcopenia and Muscle] |
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| Researchers explored the effects of acetylcholine receptor (AChR) antibodies binding to mature human myotubes with agrin-induced AChR clusters and pathways relevant for AChR degradation using bulk RNA sequencing. [Scientific Reports] |
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| Micropattern traction microscopy was used to study a wide range of focal adhesion traction forces generated by bovine vascular smooth muscle cells and bovine aortic endothelial cells cultured on substrates of stiffness of 3.6, 6.7, 13.6, and 30 kPa. [Acta Biomaterialia] |
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| Researchers showed that within a single scaffold, the architecture supported alignment of contractile smooth muscle cells and deposition by fibroblasts of a meshwork of extracellular matrix fibrils. [Journal of Biomedical Materials Research Part A] |
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| Sclerostin is becoming a marker for clinical and subclinical vascular diseases and several lines of evidence illustrate its role in the pathophysiology of the vascular system. [International Journal of Molecular Sciences] |
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| International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country. [STAT News] |
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| A new US immigration policy, which threatens to revoke visas for certain international students if they are not taking in-person classes, is stirring panic and confusion and causing some universities to push back with lawsuits. [Science] |
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| July 20 – July 22 Virtual |
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| Duke University – Durham, North Carolina, United States |
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| Novo Nordisk A/S – Måløv, Denmark |
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| Albert Einstein College of Medicine – Bronx, New York, United States |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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