| Vol. 5.26 – 20 July, 2020 |
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| Researchers examined Mitsugumin 53 secretion in response to ischemic preconditioning and explored the underlying mechanism using rodents in in vivo, isolated perfused hearts, and cultured neonatal rat ventricular cardiomyocytes. [Circulation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using human induced pluripotent stem cell-derived cardiomyocytes, scientists model iron overload cardiomyopathy and screen for drugs to rescue the iron overload phenotypes. [Cell Reports] |
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| When transplanted into athymic rat hearts, proliferative capacity was lower for nodal-like than working-type cardiomyocytes with grafted cardiomyocytes eventually comprising only relatively matured ventricular cardiomyocytes. [Scientific Data] |
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| The authors demonstrated interfacing of cardiomyocytes derived from human induced pluripotent stem cells, which were engineered to express Channelrhodopsin-2. [npj Flexible Electronics] |
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| After day five, as myoblast migration and differentiation started, genes for basement membrane constituents were found down-regulated, whereas genes for extracellular matrix molecules, macrophage, myoblast adhesion, and migration receptors were up-regulated. [Journal of Cellular and Molecular Medicine] |
| | Dystrophy type 1 skeletal muscle satellite cell (SSC) lines and primary SSCs showed decreased muscleblind-like 1 expression and elevated autophagy levels. [Cell Death & Disease] |
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| Scientists built a comprehensive profile of metabolites in primary human skeletal muscle cells during myogenic progression in an untargeted metabolomics approach using a high resolution Orbitrap Fusion Tribrid Mass Spectrometer. [Scientific Reports] |
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| The authors conducted a comprehensive single-cell RNA-seq of advanced human carotid endarterectomy samples and compared these with scRNA-seq from murine micro-dissected advanced atherosclerotic lesions with smooth muscle cells. [Circulation] |
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| 5-aminolevulinic acid-mediated sonodynamic therapy inhibited neointima formation without affecting re-endothelialization, increased blood perfusion, decreased the content of macrophages, proliferating smooth muscle cells and collagen but increased elastin by day 28. [Scientific Reports] |
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| The authors summarize the most recent studies that have revealed the function of the Hippo pathway in heart regeneration and homeostasis. [Biomolecules] |
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| Nexien BioPharma, Inc. announced that it was issued a patent by the United States Patent and Trademark Office. This patent covers methods and compositions for treating patients having non-dystrophic myotonia and myotonic dystrophies with oral formulations of cannabidiol and tetrahydrocannabinol. [Nexien BioPharma, Inc. (BusinessWire, Inc.)] |
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| Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing. [Nature News] |
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| Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences. [Science Insider] |
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| October 20 – October 21 Virtual |
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| Duke University – Durham, North Carolina, United States |
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| Novo Nordisk A/S – Måløv, Denmark |
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| Spanish National Center for Cardiovascular Research – Madrid, Spain |
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| Spanish National Center for Cardiovascular Research – Madrid, Spain |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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