Muscle Cell News Volume 5.26 | Jul 20 2020

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    MUSCN 5.26 | July 20 2020


    Muscle Cell News by STEMCELL Technologies
    Vol. 5.26 – 20 July, 2020
    TOP STORY

    Cardiac Ischemic Preconditioning Promotes MG53 Secretion through H2O2-Activated PKC-δ Signaling

    Researchers examined Mitsugumin 53 secretion in response to ischemic preconditioning and explored the underlying mechanism using rodents in in vivo, isolated perfused hearts, and cultured neonatal rat ventricular cardiomyocytes.
    [Circulation]

    Abstract

    a6b79c2b-118d-4b2b-a71e-6239c561b622_ON810MYO-MyoCult
    PUBLICATIONSRanked by the impact factor of the journal

    Modeling Secondary Iron Overload Cardiomyopathy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

    Using human induced pluripotent stem cell-derived cardiomyocytes, scientists model iron overload cardiomyopathy and screen for drugs to rescue the iron overload phenotypes.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Increased Predominance of the Matured Ventricular Subtype in Embryonic Stem Cell-Derived Cardiomyocytes In Vivo

    When transplanted into athymic rat hearts, proliferative capacity was lower for nodal-like than working-type cardiomyocytes with grafted cardiomyocytes eventually comprising only relatively matured ventricular cardiomyocytes.
    [Scientific Data]

    Full Article

    Printed Elastic Membranes for Multimodal Pacing and Recording of Human Stem-Cell-Derived Cardiomyocytes

    The authors demonstrated interfacing of cardiomyocytes derived from human induced pluripotent stem cells, which were engineered to express Channelrhodopsin-2.
    [npj Flexible Electronics]

    Full Article

    Gene Expression Profile of Adhesion and Extracellular Matrix Molecules during Early Stages of Skeletal Muscle Regeneration

    After day five, as myoblast migration and differentiation started, genes for basement membrane constituents were found down-regulated, whereas genes for extracellular matrix molecules, macrophage, myoblast adhesion, and migration receptors were up-regulated.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    MBNL1 Reverses the Proliferation Defect of Skeletal Muscle Satellite Cells in Myotonic Dystrophy Type 1 by Inhibiting Autophagy via the mTOR Pathway

    Dystrophy type 1 skeletal muscle satellite cell (SSC) lines and primary SSCs showed decreased muscleblind-like 1 expression and elevated autophagy levels.
    [Cell Death & Disease]

    Full Article

    Metabolomic Analysis of Primary Human Skeletal Muscle Cells during Myogenic Progression

    Scientists built a comprehensive profile of metabolites in primary human skeletal muscle cells during myogenic progression in an untargeted metabolomics approach using a high resolution Orbitrap Fusion Tribrid Mass Spectrometer.
    [Scientific Reports]

    Full Article

    The Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis

    The authors conducted a comprehensive single-cell RNA-seq of advanced human carotid endarterectomy samples and compared these with scRNA-seq from murine micro-dissected advanced atherosclerotic lesions with smooth muscle cells.
    [Circulation]

    Abstract

    Early Modulation of Macrophage ROS-PPARγ-NF-κB Signaling by Sonodynamic Therapy Attenuates Neointimal Hyperplasia in Rabbits

    5-aminolevulinic acid-mediated sonodynamic therapy inhibited neointima formation without affecting re-endothelialization, increased blood perfusion, decreased the content of macrophages, proliferating smooth muscle cells and collagen but increased elastin by day 28.
    [Scientific Reports]

    Full Article

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    REVIEWS

    The Hippo Pathway in Cardiac Regeneration and Homeostasis: New Perspectives for Cell-Free Therapy in the Injured Heart

    The authors summarize the most recent studies that have revealed the function of the Hippo pathway in heart regeneration and homeostasis.
    [Biomolecules]

    Full Article

    INDUSTRY AND POLICY NEWS

    Nexien BioPharma, Inc. Has Been Issued a US Patent for the Methods and Compositions for Treating Non-Dystrophic Myotonia and Myotonic Dystrophies Types 1 and 2

    Nexien BioPharma, Inc. announced that it was issued a patent by the United States Patent and Trademark Office. This patent covers methods and compositions for treating patients having non-dystrophic myotonia and myotonic dystrophies with oral formulations of cannabidiol and tetrahydrocannabinol.
    [Nexien BioPharma, Inc. (BusinessWire, Inc.)]

    Press Release

    Open-Access Plan S to Allow Publishing in Any Journal

    Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing.
    [Nature News]

    Press Release

    During the Pandemic, Students Do Field and Lab Work without Leaving Home

    Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences.
    [Science Insider]

    Press Release

    FEATURED EVENT

    The New York Stem Cell Foundation (NYSCF) Conference

    October 20 – October 21
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cardiac Regeneration

    Duke University – Durham, North Carolina, United States

    In Vitro Scientist – Atherosclerosis and Cardiovascular Research

    Novo Nordisk A/S – Måløv, Denmark

    Postdoctoral Position – Cardiovascular Molecular Mechanics

    Spanish National Center for Cardiovascular Research – Madrid, Spain

    Postdoctoral Position – Muscle Function

    Spanish National Center for Cardiovascular Research – Madrid, Spain

    Postdoctoral Researcher/Surgery – Muscle Fibrosis

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    > See All Jobs

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