 | | Vol. 5.28 – 10 August, 2020 |
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| The authors provide an overview of exercise metabolism and the key regulatory mechanisms ensuring that ATP resynthesis is closely matched to the ATP demand of exercise.
[Nature Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Mesenchymal stem cells, endothelial progenitor cells and c-Kit+ cardiac interstitial cells when cultured together spontaneously formed scaffold-free 3D microenvironments termed CardioClusters.
[Nature Communications] |
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| Researchers investigated the metabolic landscape of Danon disease by applying a multi-omics approach and combined structural and functional readouts provided by Raman and atomic force microscopy.
[Journal of Clinical Medicine] |
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| Scientists tested the impact of paracrine signals on human cardiomyocytes, using human pluripotent stem cell-derived cardiomyocytes as the target of mouse and human cardiac mesenchymal stromal cells with progenitor-like features.
[Scientific Reports] |
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| Investigators employed a translationally relevant large animal model with Diabetic Metabolic Derangement, having similar anatomic, physiologic and metabolic characteristics of the cardiovascular system with the human situation.
[Scientific Reports] |
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| Young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro.
[Journal of Cachexia Sarcopenia and Muscle] |
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| Investigators showed that extracellular vesicles released by mesenchymal cells mediated microRNA transfer to muscle stem cells.
[EMBO Reports] |
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| Scientists used an integrative genomics approach to profile muscle stem cells from young and aged animals before and after injury. Integration of these datasets revealed aging impacts multiple regulatory changes through significant differences in gene expression, metabolic flux, chromatin accessibility, and patterns of transcription factor binding activities.
[Cell Reports] |
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| The authors investigated the role of vitamin D in myogenesis and muscle fiber maintenance in an immortalized mouse myogenic cell line.
[Nutrients] |
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| | Investigators report the existence of a communication system among human smooth muscle cells that used mechanical forces to frequency modulate long-range calcium waves.
[Science Advances] |
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| Investigators demonstrated that pyruvate kinase M2 stimulated inflammatory and apoptosis signaling pathways in pulmonary artery smooth muscle cells (PASMCs) and promoted PASMC migration and proliferation.
[Cell and Tissue Research] |
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| Reverse transcription polymerase chain reaction was employed to detect miR‐20a‐5p and ATP‐binding cassette subfamily A member 1 messenger RNA expression.
[Journal of Biochemical and Molecular Toxicology] |
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| Researchers compile the literature describing recent advances in research on dedifferentiation, with an emphasis on tissue-specific findings, cellular mechanisms, and potential therapeutic applications.
[NPJ Regenerative Medicine] |
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| The authors describe the molecular regulation of lysosome biogenesis and detail the emerging anabolic roles of the lysosome in skeletal muscle with particular emphasis on how these roles may mediate adaptations to chronic resistance exercise.
[American Journal of Physiology-Cell Physiology] |
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| Corbus Pharmaceuticals Holdings, Inc. announced the completion of subject enrollment in DETERMINE, a Phase III study assessing the efficacy and safety of lenabasum for the treatment of dermatomyositis. The company expects to report topline results from this study in the fourth quarter of 2021.
[Corbus Pharmaceuticals Holdings, Inc.] |
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| October 12 – October 14
Paris, France |
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| | UPMC Children’s Hospital of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Duke University – Durham, North Carolina, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Novo Nordisk A/S – Måløv, Denmark |
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