Muscle Cell News Volume 5.30 | Aug 24 2020

May 12, 2022

MUSCN 5.30 | 24 Aug 2020

Muscle Cell News by STEMCELL Technologies

Vol. 5.30 – 24 August, 2020

TOP STORY

Myofiber
Necroptosis Promotes Muscle Stem Cell Proliferation via Releasing Tenascin-C During Regeneration

By releasing factors into the muscle stem cell (MuSC) microenvironment, necroptotic myofibers facilitated muscle regeneration. Tenascin-C, released by necroptotic myofibers, was found to be critical for MuSC proliferation.
[Cell Research]

Full Article

Virtual Conference Exhibition: Pluripotent Stem Cells

PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

A
Specialized Population of Periostin-Expressing Cardiac Fibroblasts Contributes to Postnatal Cardiomyocyte Maturation and Innervation

In order to better understand cardiac fibroblast (CF) functions in heart maturation and postnatal cardiomyocyte cell-cycle arrest, scientists have performed gene expression profiling and ablation of postnatal CF populations.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

MicroRNA-99b-3p
Promotes Angiotensin II-Induced Cardiac Fibrosis in Mice by Targeting GSK-3β

Upregulation of miR-99b-3p and fibrotic responses were observed in cultured rat cardiac fibroblasts treated with angiotensin II in vitro.
[Acta Pharmacologica Sinica]

Abstract

SKELETAL MUSCLE CELLS

Inhibition
of Inflammatory CCR2 Signaling Promotes Aged Muscle Regeneration and Strength Recovery after Injury

Researchers found stimulation of CC-chemokine-receptor 2-activity inhibited myogenic progenitor fusion and contribution to myofibers. This occured in association with increases in MAPKp38δ/γ signaling, MyoD phosphorylation, and repression of the terminal myogenic commitment factor Myogenin.
[Nature Communications]

Full Article

A
Cell Atlas of Adult Muscle Precursors Uncovers Early Events in Fibre-Type Divergence in Drosophila

Researchers identified distinct transcriptional signatures for indirect flight muscle and direct flight muscle myoblasts that underlie the molecular basis of their divergence.
[EMBO Reports]

Full Article Graphical Abstract

MICAL2 Is Essential for Myogenic Lineage Commitment

Scientists found that Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2 (MICAL2) increased during myogenic differentiation of adult and pluripotent stem cells towards skeletal, smooth and cardiac muscle cells and localized in the nucleus of acute and chronic regenerating muscle fibers.
[Cell Death & Disease]

Full Article

Targeting cPLA₂
Derived Lipid Hydroperoxides as a Potential Intervention for Sarcopenia

Investigators showed that loss of innervation in several muscle atrophy models including aging induced generation of lipid hydroperoxides produced by arachidonic acid metabolism in the cPLA2 pathway contributing to loss of muscle mass.
[Scientific Reports]

Full Article

Imaging ATP Consumption in Resting Skeletal Muscle: One Molecule at a Time

Researchers imaged the binding lifetime and location of single, fluorescently-labeled BODIPY-adenosine triphosphate molecules in relaxed skeletal muscle sarcomeres from rat soleus.
[Biophysical Journal]

Abstract

SMOOTH MUSCLE CELLS

Upregulation
of Orai1 and Increased Calcium Entry Contribute to Angiotensin II-Induced Human Coronary Smooth Muscle Cell Proliferation

Scientists showed that Angiotensin (Ang) II-induced human coronary smooth muscle cell (HCSMC) proliferation was associated with increased calcium entry. The expression of Orai1, but not that of Stim1, was significantly upregulated in Ang II-treated HCSMCs.
[Peptides]

Abstract

hPSC-derived cardiomycyte generated by STEMdiff™ Cardiomyocyte Differentiation Kit

REVIEWS

Modified mRNA as a Therapeutic Tool for the Heart

The authors present a comprehensive overview of modified mRNA’s role in cardiomyocyte proliferation, cardiac vascularization, and prevention of cardiac apoptosis.
[Cardiovascular Drugs and Therapy]

Full Article

INDUSTRY AND POLICY NEWS

Audentes
Therapeutics Provides Update on the ASPIRO Clinical Trial Evaluating AT132 in Patients with X-linked Myotubular Myopathy

Audentes Therapeutics, Inc. announced that a third study patient has passed away in the ASPIRO clinical trial evaluating AT132 in patients with X-linked Myotubular Myopathy, which is a serious, life-threatening neuromuscular disease characterized by extreme muscle weakness, respiratory failure, and early death.
[Audentes Therapeutics, Inc. (Businesss Wire)]

Press Release

Triplet
Therapeutics Announces Participation in Natural History Study of Myotonic Dystrophy Type 1

Triplet Therapeutics, Inc. announced its participation in Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1, a large international natural history study designed to advance understanding of myotonic dystrophy type 1 and ultimately support the development of new clinical approaches to address this unmet medical need.
[Triplet Therapeutics, Inc. (Business Wire)]

Press Release

FEATURED EVENT

Myofiber
Necroptosis Promotes Muscle Stem Cell Proliferation via Releasing Tenascin-C During Regeneration

A
Specialized Population of Periostin-Expressing Cardiac Fibroblasts Contributes to Postnatal Cardiomyocyte Maturation and Innervation

MicroRNA-99b-3p
Promotes Angiotensin II-Induced Cardiac Fibrosis in Mice by Targeting GSK-3β

Inhibition
of Inflammatory CCR2 Signaling Promotes Aged Muscle Regeneration and Strength Recovery after Injury

A
Cell Atlas of Adult Muscle Precursors Uncovers Early Events in Fibre-Type Divergence in Drosophila

MICAL2 Is Essential for Myogenic Lineage Commitment

Targeting cPLA₂
Derived Lipid Hydroperoxides as a Potential Intervention for Sarcopenia

Imaging ATP Consumption in Resting Skeletal Muscle: One Molecule at a Time

Upregulation
of Orai1 and Increased Calcium Entry Contribute to Angiotensin II-Induced Human Coronary Smooth Muscle Cell Proliferation

Modified mRNA as a Therapeutic Tool for the Heart

Audentes
Therapeutics Provides Update on the ASPIRO Clinical Trial Evaluating AT132 in Patients with X-linked Myotubular Myopathy

Triplet
Therapeutics Announces Participation in Natural History Study of Myotonic Dystrophy Type 1

Vascular Biology 2020

> See All Events

Postdoctoral
Fellow – Therapeutic Genetics in Congenital Muscular Dystrophy

Postdoctoral
Research Associate – Translational Cancer

Postdoc Position – Cardiovascular Research

Postdoctoral
Fellow – Cardiac Regeneration

Postdoctoral
Position – Cardiovascular and Cardiomyopathy Research

> See All Jobs