| Vol. 5.31 – 31 August, 2020 |
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| Investigators showed that canonical Wnt signaling in mesoderm was critical to confer trachea mesenchymal identity in human and mouse. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers characterized the mechanisms behind enhanced cardiomyocyte adhesion and hyper-adhesion. Dissociation assays performed in HL-1 cells and murine ventricular cardiac slice cultures allowed them to define a set of signaling pathways regulating cardiomyocyte adhesion under basal and hyper-adhesive conditions. [JCI Insight] |
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| Scientists defined a novel role for vertebrate Llgl1 in regulating Yap stability in cardiomyocytes, which impacts heart development. [Development] |
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| Experiments with neonatal rat cardiomyocyte monolayers grown on nanovolcano arrays demonstrated that electroporation pulses with characteristics derived from analytical models increased the efficiency of nanovolcano recordings. [Microsystems & Nanoengineering] |
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| Scientists investigated a novel mechanism underlying skeletal muscle atrophy. They examined AQP4 expression and its regulation in muscle using the rotator cuff tear model. [Scientific Reports] |
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| Superoxide dismutase 1 (SOD1) myotubes had loosely arranged myosin heavy chain and reduced acetylcholine receptor expression per immunocytochemical analysis. Functional analysis indicated considerably reduced contractile force and synchrony in SOD1 myotubes. [Scientific Reports] |
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| Investigators assumed that the hybrid training promoted metabolism of the whole skeletal muscle including lipids, which reduced the amount of intramyocellular lipid, and led to a secondary enlargement of the diffusion space in the skeletal muscle cells. [Magnetic Resonance Imaging] |
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| ReNcell-extracellular vesicles inhibited hypoxia-induced proliferation, migration, and phenotype switch of pulmonary artery smooth muscle cells. [Hypertension] |
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| A series of mimic, inhibitor or siRNA plasmids were delivered into vascular smooth muscle cells (VSMCs) to explore the effects of miR-22 and p38MAPKα in controlling VSMCs apoptosis in vitro. [Molecular Therapy-Nucleic Acids] |
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| In mouse vascular smooth muscle cell (VSMC) cultures, osteoprotegerin treatment upregulated the expression of collagen and TGF-β1 genes, and activated VSMC proliferation; the inhibition of TGF-β1 signaling nullified this effect. [Journal of the American Heart Association] |
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| Analysis of splenic artery aneurysms revealed the presence of atherosclerotic lesions, calcifications, and intraluminal thrombus. Splenic artery aneurysms were characterized by a profound vascular remodeling with a dramatic loss of vascular smooth muscle cells, elastin degradation, adventitial fibrosis associated with enhanced apoptosis, and increased matrix metalloproteinase 9 expression. [Angiology] |
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| The use of model organisms, such as mice, rats, flies, and worms, has advanced the field of sarcopenia research by identifying therapeutic strategies and genetic mutations that result in improved muscle mass and function of elderly animals. [Aging Cell] |
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INDUSTRY AND POLICY NEWSGenetics |
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| Cure SMA and Cytokinetics announced the renewal of their partnership to increase education, awareness, public policy and fundraising for spinal muscular atrophy (SMA). [Cure SMA (Globe Newswire, Inc.)] |
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| November 18, 2020 Virtual |
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| Albert Einstein College of Medicine – New York, New York, United States |
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| Duke University – Durham, North Carolina, United States |
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| University of California, Davis – Davis, California, United States |
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| University of North Carolina at Chapel Hill – Chapel Hill, North Carolina, United States |
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| UPMC Children’s Hospital of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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