Muscle Cell News Volume 5.34 | Sep 28 2020

May 12, 2022

2020-28-09 | MUSCN 5.34

Muscle Cell News by STEMCELL Technologies

Vol. 5.34 – 28 September, 2020

TOP STORY

Single-Cell
Genomics Reveals a Novel Cell State during Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human

To reveal the trajectories of smooth muscle cell (SMC) transdifferentiation during atherosclerosis and to identify molecular targets for disease therapy, researchers combined SMC fate mapping and single-cell RNA sequencing of both mouse and human atherosclerotic plaques.
[Circulation]

Abstract

hPSC-derived cardiomycyte generated by STEMdiff™ Cardiomyocyte Differentiation Kit

PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

Transplanted
Microvessels Improve Pluripotent Stem Cell–Derived Cardiomyocyte Engraftment and Cardiac Function after Infarction in Rats

Ready-made microvessels promoted a sixfold increase in human induced pluripotent stem cell–derived cardiomyocyte (hiPSC-CM) survival and superior functional recovery when compared to hiPSC-CMs transplanted alone or cotransplanted with a suspension of dissociated endothelial cells in infarcted rat hearts.
[Science Translational Medicine]

Abstract

LRP6 Downregulation Promotes Cardiomyocyte Proliferation and Heart Regeneration

Researchers investigated the role of lipoprotein receptor-related protein 6 (LRP6) in heart repair through regulation of cardiomyocyte proliferation. Lrp6 deficiency increased cardiomyocyte cell cycle activity in neonatal, juvenile and adult mice.
[Cell Research]

Full Article

Transcriptomic
Profiling of Human Cardiac Cells Predicts Protein Kinase Inhibitor-Associated Cardiotoxicity

Investigators obtained transcriptional profiles of human heart-derived primary cardiomyocyte like cell lines treated with a panel of 26 FDA-approved kinase inhibitors and classified their effects on subcellular pathways and processes.
[Nature Communications]

Full Article

SARS-CoV-2
Infects and Induces Cytotoxic Effects in Human Cardiomyocytes

The authors demonstrated that SARS-CoV-2 infects cardiomyocytes in vitro in an ACE2- and cathepsin-dependent manner.
[Cardiovascular Research]

Abstract Graphical Abstract

12-O-Tetradecanoylphorbol-13-Acetate
Increases Cardiomyogenesis through PKC/ERK Signaling

Scientists showed that 12-O-tetradecanoylphorbol-13-acetate can be applied as a cardiomyogenesis-promoting factor for the differentiation of mouse embryonic stem cells in vitro.
[Scientific Reports]

Full Article

SKELETAL MUSCLE CELLS

Linc‐MYH
Configures INO80 to Regulate Muscle Stem Cell Numbers and Skeletal Muscle Hypertrophy

Investigators describe that the evolutionary conserved long non‐coding RNA linc‐MYH regulated the composition of the INO80 chromatin remodeler complex in muscle stem cells and prevented interaction with WDR5 and the transcription factor YY1.
[EMBO Journal]

Abstract Graphical Abstract

Body Temperature-Dependent MicroRNA Expression Analysis in Rats: rno-miR-374-5p
Regulates Apoptosis in Skeletal Muscle Cells via Mex3B under Hypothermia

To elucidate the molecular mechanism of homeostasis in hypothermia and identify novel molecular markers to inform the diagnosis of fatal hypothermia, researchers focused on microRNA expression in skeletal muscle, which plays a role in cold-induced thermogenesis in mammals.
[Scientific Reports]

Full Article

SMOOTH MUSCLE CELLS

Circular
RNA CDR1as Promotes Pulmonary Artery Smooth Muscle Cell Calcification by Upregulating CAMK2D and CNN3 via Sponging miR-7-5p

Scientists investigated the implication and regulatory effect of a typical circular RNA, CDR1as, in the pathological process of vascular calcification in pulmonary hypertension.
[Molecular Therapy-Nucleic Acids]

Abstract Graphical Abstract

Derive and expand human skeletal muscle progenitors in a serum-free setting using MyoCult™-SF Expansion Supplement Kit (Human)

REVIEWS

Autophagy and Cardiac Diseases: Therapeutic Potential of Natural Products

The authors focus on the role of autophagy in various cardiac diseases and the pharmacological basis and therapeutic potential of reported natural products in cardiac diseases by modifying autophagic processes.
[Medicinal Research Reviews]

Abstract

INDUSTRY AND POLICY NEWS

Muscular
Dystrophy Association Awards 15 Grants Totaling More Than $4 Million for Neuromuscular Disease Research

The Muscular Dystrophy Association (MDA) announced the awarding of 15 new MDA grants totaling more than $4 million toward research focused on a variety of neuromuscular diseases, including Duchenne muscular dystrophy, Charcot-Marie-Tooth disease, Becker’s muscular dystrophy, spinal muscular atrophy, amyotrophic lateral sclerosis, myotonic dystrophy type 1 and facioscapulohumeral muscular dystrophy.
[The Muscular Dystrophy Association]

Press Release

Sarepta Therapeutics Investigational Gene Therapy SRP-9003 for the Treatment of Limb-Girdle Muscular Dystrophy Type 2E Shows Sustained Functional Improvements 18-months after Administration

Sarepta Therapeutics, Inc. announced positive results from the ongoing study of SRP-9003, the company’s investigational gene therapy for limb-girdle muscular dystrophy Type 2E.
[Sarepta Therapeutics, Inc. (GlobeNewswire, Inc.)]

Press Release

FEATURED EVENT

Single-Cell
Genomics Reveals a Novel Cell State during Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human

Transplanted
Microvessels Improve Pluripotent Stem Cell–Derived Cardiomyocyte Engraftment and Cardiac Function after Infarction in Rats

LRP6 Downregulation Promotes Cardiomyocyte Proliferation and Heart Regeneration

Transcriptomic
Profiling of Human Cardiac Cells Predicts Protein Kinase Inhibitor-Associated Cardiotoxicity

SARS-CoV-2
Infects and Induces Cytotoxic Effects in Human Cardiomyocytes

12-O-Tetradecanoylphorbol-13-Acetate
Increases Cardiomyogenesis through PKC/ERK Signaling

Linc‐MYH
Configures INO80 to Regulate Muscle Stem Cell Numbers and Skeletal Muscle Hypertrophy

Body Temperature-Dependent MicroRNA Expression Analysis in Rats: rno-miR-374-5p
Regulates Apoptosis in Skeletal Muscle Cells via Mex3B under Hypothermia

Circular
RNA CDR1as Promotes Pulmonary Artery Smooth Muscle Cell Calcification by Upregulating CAMK2D and CNN3 via Sponging miR-7-5p

Autophagy and Cardiac Diseases: Therapeutic Potential of Natural Products

Muscular
Dystrophy Association Awards 15 Grants Totaling More Than $4 Million for Neuromuscular Disease Research

Sarepta Therapeutics Investigational Gene Therapy SRP-9003 for the Treatment of Limb-Girdle Muscular Dystrophy Type 2E Shows Sustained Functional Improvements 18-months after Administration

49^th European Muscle Conference

> See All Events

Faculty
Position – Cytoskeleton, Molecular Motors or Contractile Systems

Postdoctoral Research Fellow – Skeletal Muscle

Postdoctoral Fellow – Cardiac Regeneration

Project Scientist – Division of Cardiovascular Medicine

Postdoctoral Research Associate – Translational Cancer

> See All Jobs