Muscle Cell News Volume 5.36 | Oct 19 2020

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    2020-10-19 | MUSCN 5.36


    Muscle Cell News by STEMCELL Technologies
    Vol. 5.36 – 19 October, 2020
    TOP STORY

    Inhibition
    of Aquaporin-1 Prevents Myocardial Remodeling by Blocking the Transmembrane Transport of Hydrogen Peroxide

    Researchers showed that hydrogen peroxide (H2O2), produced extracellularly, was necessary for the hypertrophic response of isolated cardiac myocytes and that aquaporin-1 facilitated the transmembrane transport of H2O2 through its water pore, resulting in activation of oxidant-sensitive kinases in cardiac myocytes.
    [Science Translational Medicine]

    Abstract


    hPSC-derived cardiomycyte generated by STEMdiff™ Cardiomyocyte Differentiation Kit
    PUBLICATIONSRanked by the impact factor of the journal
    CARDIAC MUSCLE CELLS

    Dioxin Disrupts Dynamic DNA Methylation Patterns in Genes that Govern Cardiomyocyte Maturation

    To test the hypothesis that the disruption caused by tetrachlorodibenzo-p-dioxin in the heart results from changes in DNA methylation and gene expression patterns of cardiomyocytes, scientists established a stable mouse embryonic stem cell line expressing a puromycin resistance selectable marker under control of the cardiomyocyte-specific Nkx2-5 promoter.
    [Toxicological Sciences]

    Abstract

    Effects of Fibrillin Mutations on the Behavior of Heart Muscle Cells in Marfan Syndrome

    Both induced pluripotent stem cells derived from a Marfan syndrome (MFS)-patient and the line with the corrected fibrillin-1 mutation were differentiated to cardiomyocytes. Several functional analyses were performed on this model to study MFS related cardiomyopathy.
    [Scientific Reports]

    Full Article

    Hydrojet-Based Delivery of Footprint-Free iPSC-Derived Cardiomyocytes Into Porcine Myocardium

    Scientists analyzed the applicability of a hydrojet-based method to deliver footprint-free induced pluripotent stem cell-derived cardiomyocytes into the myocardium.
    [Scientific Reports]

    Full Article

    Minimal Contribution of IP3R2 in Cardiac Differentiation and Derived Ventricular-Like Myocytes from Human Embryonic Stem Cells

    Thre authors investigated the role of Type 2 inositol 1,4,5-trisphosphate receptor (IP3R2) in the differentiation of human embryonic stem cells (hESCs) to cardiomyocytes and in the hESC-derived cardiomyocytes.
    [Acta Pharmacologica Sinica]

    Abstract

    SKELETAL MUSCLE CELLS

    The Rho-GEF PIX-1 Directs Assembly or Stability of Lateral Attachment Structures between Muscle Cells

    Researchers showed that a PIX protein has an important function in muscle. From a genetic screen in C. elegans, they found that pix-1 was required for the assembly of integrin adhesion complexes at borders between muscle cells, and was required for locomotion of the animal.
    [Nature Communications]

    Full Article

    BNIP3L/Nix-Induced Mitochondrial Fission, Mitophagy, and Impaired Myocyte Glucose Uptake Are Abrogated by PRKA/PKA Phosphorylation

    In a series of gain-of-function and loss-of-function experiments in rodent and human myotubes, scientists demonstrated that BNIP3L accumulation triggered mitochondrial depolarization, calcium-dependent activation of DNM1L/DRP1, and mitophagy.
    [Autophagy]

    Full Article

    DUX4 Transcript Knockdown with Antisense 2′-O-Methoxyethyl Gapmers for the Treatment of Facioscapulohumeral Muscular Dystrophy

    Using immortalized patient-derived muscle cells and local intramuscular injections in the FLExDUX4 FSHD mouse model, investigators showed that their designed 2’-MOE gapmers significantly reduced DUX4 transcript levels in vitro and in vivo, respectively.
    [Molecular Therapy]

    AbstractGraphical Abstract

    MiR-324-5p Inhibits C2C12 Myoblasts Differentiation and Promotes Intramuscular Lipid Deposition through LncDUM and PM20D1, Respectively

    Researchers investigated the role of mmu-miR-324-5p in the differentiation of C2C12 myoblasts and lipid droplet deposition in myotubes for future targeted therapies.
    [Molecular Therapy-Nucleic Acids]

    AbstractGraphical Abstract

    ActivinA Activates Notch1-Shh Signaling to Regulate Proliferation in C2C12 Skeletal Muscle Cells

    Scientists determined the physiological functions of Activin A, Notch and Sonic Hedgehog signaling in the proliferation of mouse C2C12 myoblasts and explored their interactions.
    [Molecular and Cellular Endocrinology]

    Full Article

    SMOOTH MUSCLE CELLS

    All-Trans
    Retinoic Acid Prevented Vein Grafts Stenosis by Inhibiting Rb-E2F Mediated Cell Cycle Progression and KLF5-RARα Interaction in Human Vein Smooth Muscle Cells

    All-trans retinoic acid (ATRA) could repress the PDGF-bb-induced excessive proliferation and migration of human umbilical vein smooth muscle cells, which was mediated by Rb-E2F dependent cell cycle inhibition.
    [Cardiovascular Drugs and Therapy]

    Abstract


    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart
    REVIEWS

    Myogenic,
    Genomic and Non‐Genomic Influences of the Vitamin D Axis in Skeletal Muscle

    The authors consider the biomolecular role for the vitamin D/Vitamin D receptor (VDR) axis in myogenesis, while also exploring global evidence for genomic and non‐genomic mechanisms of action for 1,25(OH)2D3/VDR.
    [Cell Biochemistry and Function]

    Full Article

    INDUSTRY AND POLICY NEWS

    Revance
    Reports Positive Results from ASPEN-1 Phase 3 Trial of DaxibotulinumtoxinA for Injection in Cervical Dystonia

    Revance Therapeutics, Inc. announced positive topline results from its ASPEN-1 Phase III randomized, double-blind, placebo-controlled, parallel group clinical trial for its investigational drug candidate DaxibotulinumtoxinA for injection for the treatment of cervical dystonia, a chronic and debilitating neurologic condition affecting the muscles of the neck.
    [Revance Therapeutics, Inc.]

    Press Release

    Italfarmaco Receives FDA Rare Pediatric Disease Designation for Givinostat in Duchenne Muscular Dystrophy, Announces Completed Enrollment in EPIDYS Phase III Trial

    The US FDA have granted a Rare Pediatric Disease designation to The Italfarmaco Group’s proprietary histone deacetylase inhibitor, Givinostat, for the treatment of Duchenne Muscular Dystrophy, which allows an expedited review process for new treatment modalities. The company also announced the completion of patient enrollment in the EPIDYS Phase III trial.
    [ITALFARMACO S.p.A.]

    Press Release

    FEATURED EVENT

    Cell Symposia: 20 Years of the Human Genome: From Sequence to Substance

    April 11 – April 13, 2021
    San Diego, California, United States


    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cardiovascular Development and Regeneration

    Center for Vascular and Inflammatory Diseases – Baltimore, Maryland, United States

    Staff
    Scientist – Heart Disease Molecular Mechanisms

    Sanford Research – Sioux Falls, South Dakota, United States

    Postdoctoral Research Fellow Position – Urinary Physiology

    Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States

    Postdoctoral Fellow – Computational Systems Biology/Bioinformatics

    University of Luxembourg – Luxembourg, Luxembourg

    Faculty
    Position – Cytoskeleton, Molecular Motors or Contractile Systems

    University of Vermont – Burlington, Vermont, United States

    > See All Jobs

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