Muscle Cell News Volume 5.37 | Oct 26 2020

May 12, 2022

2020-26-10 | MUSCN 5.37

Muscle Cell News by STEMCELL Technologies

Vol. 5.37 – 26 October, 2020

TOP STORY

FoxO Maintains a Genuine Muscle Stem-Cell Quiescent State until Geriatric Age

In homeostatic skeletal muscle, scientists identified two quiescent stem-cell states distinguished by relative CD34 expression: CD34^High, with stemness properties, and CD34^Low, committed to myogenic differentiation.
[Nature Cell Biology]

Abstract

Derive and expand human skeletal muscle progenitors in a serum-free setting using MyoCult™-SF Expansion Supplement Kit (Human)

PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

BRD4
Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes

The authors showed that cardiomyocyte-specific deletion of Brd4 in adult mice led to acute deterioration of cardiac contractile function with mutant animals demonstrating a transcriptomic signature enriched for decreased expression of genes critical for mitochondrial energy production.
[Circulation]

Abstract

Redox-Resistant
SERCA Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice

Scientists hypothesized that sarco(endo)plasmic reticulum calcium ATPase oxidation at C674 would modulate the effects of reactive oxygen species on mitochondrial calcium and mitochondria-dependent apoptosis in cardiac myocytes.
[Circulation]

Abstract

Mitochondrial Pyruvate Carrier Abundance Mediates Pathological Cardiac Hypertrophy

Researchers showed that mitochondrial pyruvate carrier (MPC) abundance mediates pathological cardiac hypertrophy. MPC abundance was reduced in failing hypertrophic human hearts, as well as in the myocardium of mice induced to fail by angiotensin II or through transverse aortic constriction.
[Nature Metabolism]

Abstract

Mir-30d
Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling

In rat and mouse models of ischemic heart failure, investigators showed that miR-30d gain of function improves cardiac function, decreases myocardial fibrosis, and attenuates cardiomyocyte apoptosis.
[Circulation Research]

Abstract

Interaction of the Joining Region in Junctophilin-2 with the L-Type Ca²⁺
Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca²⁺ Dynamics

Modified abundance of junctophilin-2 and redistribution of L-type calcium channels were studied in left ventricular hypertrophy in vivo and in cultured adult feline and rat ventricular myocytes.
[Circulation Research]

Abstract

CHIP
Phosphorylation by Protein Kinase G Enhances Protein Quality Control and Attenuates Cardiac Ischemic Injury

Researchers report that carboxyl terminus of Hsc70-interacting protein-mediated protein turnover was markedly post-translationally enhanced by direct protein kinase G phosphorylation at S20.
[Nature Communications]

Full Article

SKELETAL MUSCLE CELLS

miR-322/-503
Rescues Myoblast Defects in Myotonic Dystrophy Type 1 Cell Model by Targeting CUG Repeats

Investigators discovered that miR-322/-503 rescued myoblast defects in myotonic dystrophy type 1 cell model by targeting the expanded CUG repeats.
[Cell Death & Disease]

Full Article

Substrate Utilization of Cultured Skeletal Muscle Cells in Patients with CFS

The authors outline experiments looking at the utilization of different substrates by skeletal muscle cells from chronic fatigue syndrome (CFS) patients and healthy controls using extracellular flux analysis.
[Scientific Reports]

Full Article

A
Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy

Calpain 3 deficiency is associated with impaired CaMKIIβ signaling and blunted transcriptional programs that encode the slow-oxidative muscle phenotype. Researchers conducted a high-throughput screen on a target of CaMKII to identify compounds to override this signaling defect; 4 were tested in vivo in the Capn3 knockout model of limb girdle muscular dystrophy R1.
[Cell Reports Medicine]

Full Article Graphical Abstract

SMOOTH MUSCLE CELLS

The Odorant Receptor OR2W3 on Airway Smooth Muscle Evokes Bronchodilation via a Cooperative Chemosensory Tradeoff between TMEM16A and CFTR

Investigators characterized the effects of a wide range of volatile odorants on the contractile state of airway smooth muscle (ASM) and uncovered a complex mechanism of odorant-evoked signaling properties that regulate excitation-contraction coupling in human ASM cells.
[Proceedings of the National Academy of Sciences of the United States of America]

Full Article

Lineage
Tracing Reveals Evidence of a Popliteal Lymphatic Muscle Progenitor Cell That Is Distinct from Skeletal and Vascular Muscle Progenitors

Researchers characterized the progenitors of popliteal lymphatic vessel (PLV)-lymphatic muscle cells during murine development, towards rational therapies that target their proliferation, recruitment, and differentiation onto PLVs.
[Scientific Reports]

Full Article

hPSC-derived cardiomycyte generated by STEMdiff™ Cardiomyocyte Differentiation Kit

REVIEWS

MicroRNAs
Are Critical in Regulating Smooth Muscle Cell Mineralization and Apoptosis during Vascular Calcification

The authors discuss the roles of microRNAs in the pathophysiological mechanisms of vascular calcification in smooth muscle cells and describe several interventions against vascular calcification by regulating microRNAs.
[Journal of Cellular and Molecular Medicine]

Full Article

INDUSTRY AND POLICY NEWS

Ultragenyx
and Solid Biosciences Announce Strategic Collaboration to Develop and Commercialize New Gene Therapies for Duchenne Muscular Dystrophy

Ultragenyx Pharmaceutical Inc. and Solid Biosciences Inc. announced a strategic collaboration and license agreement to focus on the development and commercialization of new gene therapies for Duchenne.
[Ultragenyx Pharmaceutical Inc.]

Press Release

FEATURED EVENT

FoxO Maintains a Genuine Muscle Stem-Cell Quiescent State until Geriatric Age

BRD4
Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes

Redox-Resistant
SERCA Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice

Mitochondrial Pyruvate Carrier Abundance Mediates Pathological Cardiac Hypertrophy

Mir-30d
Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling

Interaction of the Joining Region in Junctophilin-2 with the L-Type Ca²⁺
Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca²⁺ Dynamics

CHIP
Phosphorylation by Protein Kinase G Enhances Protein Quality Control and Attenuates Cardiac Ischemic Injury

miR-322/-503
Rescues Myoblast Defects in Myotonic Dystrophy Type 1 Cell Model by Targeting CUG Repeats

Substrate Utilization of Cultured Skeletal Muscle Cells in Patients with CFS

A
Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy

The Odorant Receptor OR2W3 on Airway Smooth Muscle Evokes Bronchodilation via a Cooperative Chemosensory Tradeoff between TMEM16A and CFTR

Lineage
Tracing Reveals Evidence of a Popliteal Lymphatic Muscle Progenitor Cell That Is Distinct from Skeletal and Vascular Muscle Progenitors

MicroRNAs
Are Critical in Regulating Smooth Muscle Cell Mineralization and Apoptosis during Vascular Calcification

Ultragenyx
and Solid Biosciences Announce Strategic Collaboration to Develop and Commercialize New Gene Therapies for Duchenne Muscular Dystrophy

8^th
International Conference on Stem Cell Engineering 2021

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Postdoctoral Fellow – Cardiovascular Development and Regeneration

Staff
Scientist – Heart Disease Molecular Mechanisms

Postdoctoral
Research Fellow Position – Urinary Physiology

Postdoctoral Fellow – Computational Systems Biology/Bioinformatics

Faculty
Position – Cytoskeleton, Molecular Motors or Contractile Systems

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