Muscle Cell News Volume 5.38 | Nov 2 2020

May 12, 2022

2020-02-11 | MUSCN 5.38

Muscle Cell News by STEMCELL Technologies

Vol. 5.38 – 2 November, 2020

TOP STORY

Macrophage-Derived Glutamine Boosts Satellite Cells and Muscle Regeneration

The uptake of macrophage-derived glutamine by satellite cells through the glutamine transporter SLC1A5 activated mTOR and promoted the proliferation and differentiation of satellite cells.
[Nature]

Abstract

Virtual Conference Exhibition: Pluripotent Stem Cells

PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

Interleukin-1 Receptor-Induced PGE₂
Production Controls Acetylcholine-Mediated Cardiac Dysfunction and Mortality during Scorpion Envenomation

Scientists demonstrated that cardiac dysfunction and fatal outcomes caused by lethal scorpion envenomation in mice are mediated by a neuro-immune interaction linking IL-1 receptor signaling, prostaglandin E₂ (PGE₂), and acetylcholine release.
[Nature Communications]

Full Article

GDF11
Inhibits Cardiomyocyte Pyroptosis and Exerts Cardioprotection in Acute Myocardial Infarction Mice by Upregulation of Transcription Factor HOXA3

Researchers determined that growth differentiation factor 11 (GDF11) was abnormally downregulated in the heart tissue of myocardial infarction mice and hypoxic cardiomyocytes.
[Cell Death & Disease]

Full Article

Disease
Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes from Brugada Syndrome Patients with a Loss-of-Function SCN5A Mutation

The authors investigated the pathophysiological phenotypes and mechanisms using induced pluripotent stem cell (iPSC)-derived cardiomyocytes from two Brugada syndrome patients carrying a heterozygous SCN5A mutation p.S1812X.
[Frontiers in Cell and Developmental Biology]

Full Article

NSAIDs-Dependent
Adaption of the Mitochondria-Proteasome System in Immortalized Human Cardiomyocytes

Researchers evaluated the effects of Ketoprofen in comparison with Diclofenac in immortalized human cardiomyocytes. The results obtained highlight the dose-dependent cardiotoxicity of Diclofenac compared to Ketoprofen.
[Scientific Reports]

Full Article

Soluble
Factors Released by Dedifferentiated Fat Cells Reduce the Functional Activity of iPS Cell‐Derived Cardiomyocytes

Scientists evaluated the effects of soluble factor interactions in indirect cocultures of dedifferentiated fat cells and induced pluripotent stem cell‐derived cardiomyocytes.
[Cell Biology International]

Abstract

Age
and Sex Influence Mitochondria and Cardiac Health in Offspring Exposed to Maternal Glucolipotoxicity

The authors demonstrated ongoing cardiometabolic consequences by cross-fostering and following echocardiography, cardiomyocyte bioenergetics, mitochondria-mediated turnover and cell death following metabolic stress in aged adults.
[iScience]

Abstract Full Article
Graphical Abstract

Myocardial
Infarction Affects Cx43 Content of Extracellular Vesicles Secreted by Cardiomyocytes

Using a comprehensive strategy that included cell-based approaches, animal models and human patients, scientists demonstrated that myocardial ischemia impairs the secretion of Cx43 into circulating, intracardiac and cardiomyocyte-derived vesicles.
[Life Science Alliance]

Full Article

SKELETAL MUSCLE CELLS

Defective Lysosome Reformation during Autophagy Causes Skeletal Muscle Disease

Researchers showed the inositol polyphosphate 5-phosphatase INPP5K regulates autophagic lysosome reformation, a lysosome recycling pathway, in muscle. INPP5K hydrolysed phosphatidylinositol-4,5-bisphosphate to phosphatidylinositol 4-phosphate and INPP5K mutations caused muscular dystrophy by unknown mechanisms.
[Journal of Clinical Investigation]

Abstract Full Article
Graphical Abstract

Dynamin-2
Regulates Postsynaptic Cytoskeleton Organization and Neuromuscular Junction Development

Investigators revealed that dynamin-2 (Dyn2) was involved in postsynaptic development of neuromuscular junctions (NMJs). Mutations of Dyn2 have been linked to human muscular disorder and centronuclear myopathy, as well as featured with muscle atrophy and defective NMJs, yet the function of Dyn2 at the postsynaptic membrane is largely unknown.
[Cell Reports]

Full Article Graphical Abstract

Radiation-Induced Damage to Prepubertal Pax7⁺
Skeletal Muscle Stem Cells Drives Lifelong Deficits in Myofiber Size and Nuclear Number

Using a small animal radiation research platform, the authors investigated the effects of local fractionated radiation treatment on prepubertal satellite cells.
[iScience]

Abstract Full Article
Graphical Abstract

SMOOTH MUSCLE CELLS

Phosphorylation
of Msx1 Promotes Cell Proliferation through the Fgf9/18-MAPK Signaling Pathway during Embryonic Limb Development

Investigators demonstrated that Msh homeobox 1 (Msx1) promotes the proliferation of myoblasts and mesenchymal stem cells by enhancing mitogen-activated protein kinase (MAPK) signaling.
[Nucleic Acids Research]

Full Article

Generate functional cardiomyocytes from hPSCs with the STEMdiff™ Cardiomyocyte Differentiation Kit

REVIEWS

MicroRNAs
Are Critical in Regulating Smooth Muscle Cell Mineralization and Apoptosis during Vascular Calcification

The authors discuss the roles of microRNAs in the pathophysiological mechanisms of vascular calcification in smooth muscle cells and describes several interventions against vascular calcification by regulating microRNAs.
[Journal of Cellular and Molecular Medicine]

Full Article

INDUSTRY AND POLICY NEWS

Novus
Therapeutics Announces First Patient Enrolled in Phase IIa Clinical Trial of Anti-CD40L Antibody AT-1501 in Amyotrophic Lateral Sclerosis

Novus Therapeutics, Inc. announced that the first subject has been enrolled in the Phase IIa clinical trial evaluating AT-1501, the company’s lead product candidate, in adults with amyotrophic lateral sclerosis.
[Novus Therapeutics, Inc.]

Press Release

FEATURED EVENT

Macrophage-Derived Glutamine Boosts Satellite Cells and Muscle Regeneration

Interleukin-1 Receptor-Induced PGE₂
Production Controls Acetylcholine-Mediated Cardiac Dysfunction and Mortality during Scorpion Envenomation

GDF11
Inhibits Cardiomyocyte Pyroptosis and Exerts Cardioprotection in Acute Myocardial Infarction Mice by Upregulation of Transcription Factor HOXA3

Disease
Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes from Brugada Syndrome Patients with a Loss-of-Function SCN5A Mutation

NSAIDs-Dependent
Adaption of the Mitochondria-Proteasome System in Immortalized Human Cardiomyocytes

Soluble
Factors Released by Dedifferentiated Fat Cells Reduce the Functional Activity of iPS Cell‐Derived Cardiomyocytes

Age
and Sex Influence Mitochondria and Cardiac Health in Offspring Exposed to Maternal Glucolipotoxicity

Myocardial
Infarction Affects Cx43 Content of Extracellular Vesicles Secreted by Cardiomyocytes

Defective Lysosome Reformation during Autophagy Causes Skeletal Muscle Disease

Dynamin-2
Regulates Postsynaptic Cytoskeleton Organization and Neuromuscular Junction Development

Radiation-Induced Damage to Prepubertal Pax7⁺
Skeletal Muscle Stem Cells Drives Lifelong Deficits in Myofiber Size and Nuclear Number

Phosphorylation
of Msx1 Promotes Cell Proliferation through the Fgf9/18-MAPK Signaling Pathway during Embryonic Limb Development

MicroRNAs
Are Critical in Regulating Smooth Muscle Cell Mineralization and Apoptosis during Vascular Calcification

Novus
Therapeutics Announces First Patient Enrolled in Phase IIa Clinical Trial of Anti-CD40L Antibody AT-1501 in Amyotrophic Lateral Sclerosis

Keystone
Symposia: Emerging Cell Therapies: Realizing the Vision of NextGen Cell Therapeutics

> See All Events

Postdoctoral Fellow – Cardiovascular Development and Regeneration

Staff
Scientist – Heart Disease Molecular Mechanisms

Postdoctoral Research Fellow Position – Urinary Physiology

Postdoctoral Fellow – Computational Systems Biology/Bioinformatics

Faculty
Position – Cytoskeleton, Molecular Motors or Contractile Systems

> See All Jobs