 | | Vol. 5.40 – 16 November, 2020 |
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| The authors showed that the catalytic activity of Vav2, a Rho GTPase activator, modulated the signaling output of the IGF1- and insulin-stimulated phosphatidylinositol 3-kinase pathway in skeletal muscle tissue.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators tested the hypothesis that proprotein convertase subtilisin/Kexin type 9 (PCSK9) regulates pyroptosis in cardiomyocytes during chronic myocardial ischemia. Primary cardiomyocytes were isolated from WT and PCSK9−/− mice.
[Basic Research in Cardiology] |
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| Vagus nerve stimulation in vivo and acetylcholine in vitro optimized the levels of α/β-MHC and α-Actinin positive sarcomere organization in cardiomyocytes while reducing F-actin assembly of cardiomyocytes.
[Cell Death Discovery] |
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| Researchers demonstrated that it was possible to probe cardiomyocyte mobility using multi-phase and high resolution cardiac diffusion tensor imaging.
[PLoS One] |
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| Scientists measured the expression levels of prokineticin receptor 1 (Prokr1) in the skeletal muscle of mice as well as human skeletal muscle cell‐derived myotubes. Prokineticin 2, a ligand of PROKR1, induced calcium mobilization in a dose‐dependent manner and altered the mRNA levels of 578 genes in PROKR1‐overexpressed HEK293T cells.
[FASEB Journal] |
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| Investigators determined the phenotypic responses of DMD cardiomyocytes (DMD-iCMs) after long-term exposure to DMD cardiac exosomes. DMD-iCMs were vulnerable to stress, evidenced by production of reactive oxygen species, the mitochondrial membrane potential and cell death levels.
[Disease Models & Mechanisms] |
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| The authors explored the therapeutic efficacy of human induced pluripotent stem cell (iPSC)‐derived endothelial cell and iPSC‐derived smooth muscle cell in a peripheral artery disease model.
[Stem Cells Translational Medicine] |
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| Scientists investigated whether the antihypertensive peptides Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP) ameliorated the effects of extracellular vesicles from Ang II-induced vascular smooth muscles on the endothelial dysfunction.
[Journal of Agricultural and Food Chemistry] |
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| Researchers investigated whether platelet‑derived growth factor (PDGF) affected the proliferation and migration of pulmonary arterial smooth muscle cells by regulating nuclear factor of activated T cell (NFAT), and studied the pathogenesis of pulmonary arterial hypertension.
[Molecular Medicine Reports] |
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| The authors summarize the patient induced pluripotent stem cell‐derived aortic cells that have been utilized to model aortic diseases in vitro.
[Stem Cells Translational Medicine] |
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| Peptidyl-tRNA hydrolase 2 (PTRH2) is an underappreciated regulator of adhesion signals and Bcl2 expression. Its key roles in muscle differentiation and integrin-mediated signaling are central to the pathology of a recently identified patient syndrome caused by a cluster of Ptrh2 gene mutations.
[Cell Death Discovery] |
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| Scientists consolidate current literature, including their recent work, while evaluating how ubiquitin-dependent mitophagy is regulated both in muscle and non-muscle cells through the steps of mitochondrial fission, ubiquitylation and autophagosomal engulfment.
[Frontiers in Physiology] |
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| XOMA Corporation has earned a $2 million milestone payment from Takeda Pharmaceutical Company Ltd. as the first patient has been dosed in its Phase II study to evaluate safety, tolerability, and efficacy of mezagitamab in participants with generalized myasthenia gravis, a chronic autoimmune neuromuscular disorder that causes patients to experience muscle weakness that may significantly impact their quality of life.
[XOMA Corporation] |
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| September 7 – September 11, 2022
Woods Hole, Massachusetts, United States |
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| | Stanford University – Stanford, California, United States |
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| | University of Minnesota Medical School – Minneapolis, Minnesota, United States |
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| | Novo Nordisk A/S – Copenhagen, Denmark |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | Zhejiang University-University of Edinburgh Institute – Haining, China |
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