 | | Vol. 5.41 – 23 November, 2020 |
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| Using pharmacological, genetic and biophysical protein-protein interaction approaches, scientists studied the cardioprotective effect of the β2-agonist, (R,R’)-4-methoxy-1-naphthylfenoterol, and explored the underlying mechanism both in vivo in mice and cultured rodent cardiomyocytes insulted with doxorubicin, hydrogen peroxide or ischemia/reperfusion.
[Circulation Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| miR‐138‐5p was down‐regulated in hypoxia/reoxygenation (H/R)‐induced H9C2 cells. circSAMD4A was a targeted regulator of miR‐138‐5p. CircSAMD4A inhibited the expression of miR‐138‐5p to promote H/R‐induced myocardial cell injury in vitro and in vivo.
[Journal of Cellular and Molecular Medicine] |
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| | Scientists fabricated, calibrated, and tested a fibronectin-based nanomechanical biosensor that could be applied to the surface of cells and tissues to measure the magnitude, direction, and strain dynamics from subcellular to tissue length-scales.
[Nature Communications] |
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| Increasing the number of M1-like macrophages immediately after traumatic muscle injury promoted muscle recovery with less fibrosis, and this could be achieved by the transient expression of granulocyte and monocyte colony stimulating factor (GM-CSF).
[Stem Cell Research & Therapy] |
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| Researchers established myostatin (MSTN) knockout quail myoblasts and investigated the regulatory pathway of the myogenic differentiation process.
[Molecular Biology Reports] |
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| Using a variety of complementary techniques, scientists found impaired autophagic activity in the process of vascular smooth muscle cells calcification, whereas knocking down pyruvate dehydrogenase kinase 4 (PDK4) had the opposite effect.
[Cell Death & Disease] |
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| Scientists investigated the role of nucleolin in vascular smooth muscle cells (VSMCs) proliferation and cell cycle. The expression of nucleolin increased in VSMCs of mice with advanced aortic plaques.
[Journal of Cellular and Molecular Medicine] |
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| The authors defined the aortic embryologic origin-specific proteome in a validated induced pluripotent stem cell smooth muscle cell model to identify novel protein markers associated with Marfan syndrome aneurysm phenotype.
[Scientific Reports] |
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| Following osteoglycin knockdown in rat aortic smooth muscle cells, cell proliferation was detected by performing Cell Counting Kit‑8 and BrdU assays. Cell migration was assessed by performing the wound healing assay, cell invasion was detected by performing the Transwell assay, and VEGFR/AKT signaling pathway‑related protein expression levels were measured via western blotting.
[Molecular Medicine Reports] |
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| Investigators summarize the structure of skeletal muscle tissue. The role of various hydrogels, biomaterials, and scaffolds as building blocks of complex skeletal muscle structures is then explored.
[Advanced Materials Interfaces] |
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| The authors combine current clinical knowledge and basic biological mechanisms to address the critical emergence of skeletal muscle atrophy in patients with heart failure and type 2 diabetes mellitus as a key driver of symptoms.
[ESC Heart Failure] |
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| Apellis Pharmaceuticals, Inc. and Swedish Orphan Biovitrum AB announced that the first patient has been dosed in the potentially registrational Phase II MERIDIAN study of pegcetacoplan, a targeted C3 therapy, in approximately 200 adults with sporadic amyotrophic lateral sclerosis (ALS).
[Apellis Pharmaceuticals, Inc.] |
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| BrainEver announced that the FDA has granted orphan drug designation to its product BREN-02, the recombinant human homeoprotein Engrailed 1, for the treatment of ALS.
[BrainEver (Business Wire, Inc.)] |
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| March 17 – March 19, 2021
Virtual |
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| | Stanford University – Stanford, California, United States |
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| | University of Minnesota Medical School – Minneapolis, Minnesota, United States |
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| | Novo Nordisk A/S – Copenhagen, Denmark |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | Zhejiang University-University of Edinburgh Institute – Haining, China |
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