Muscle Cell News Volume 5.43 | Dec 7 2020

May 12, 2022

2020-07-12 | MUSCN 5.43

Muscle Cell News by STEMCELL Technologies

Vol. 5.43 – 7 December, 2020

TOP STORY

Endothelial Cell Indoleamine 2, 3-Dioxygenase 1 Alters Cardiac Function Following Myocardial Infarction through Kynurenine

Cardiac repair was analyzed in mice harboring specific endothelial, smooth muscle cells, cardiomyocyte or myeloid cell deficiency of indoleamine 2, 3-dioxygenase 1 and challenged with acute myocardial infarction.
[Circulation]

Abstract

How to prioritize and manage your research projects

PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

AMPK Regulates Cell Shape of Cardiomyocytes by Modulating Turnover of Microtubules through CLIP‐170

Researchers identified an active form of AMP‐activated protein kinase (AMPK) localized at the intercalated disks in the heart, a specific cell–cell junction present between cardiomyocytes.
[EMBO Reports]

Full Article Graphical Abstract

Bioinformatic Analysis of Membrane and Associated Proteins in Murine Cardiomyocytes and Human Myocardium

Scientists examined several proteomic- and RNA-Seq-based datasets of cardiac-enriched, cell-surface and membrane-associated proteins in human fetal and mouse neonatal ventricular cardiomyocytes.
[Scientific Data]

Full Article

Oxidized Low-Density Lipoprotein Associates with Ventricular Stress in Young Adults and Triggers Intracellular Ca²⁺ Alterations in Adult Ventricular Cardiomyocytes

To determine the intracellular mechanisms involved in the cardiac effects of oxidized low-density lipoprotein (oxLDL), the authors analyzed the in vitro effect of oxLDL on intracellular Ca²⁺ handling in adult rat ventricular cardiomyocytes using confocal microscopy.
[Antioxidants]

Full Article

Fast-Relaxing Cardiomyocytes Exert a Dominant Role in the Relaxation Behavior of Heterogeneous Myocardium

Investigators constructed engineered heart tissues from two lines of fast- and slow-relaxing human iPSC-derived cardiomyocytes. Cell tracking via fluorescent nanocrystals confirmed the presence of both cell populations in the 50/50 mixed tissues at the time of mechanical characterization.
[Archives of Biochemistry and Biophysics]

Abstract

SGLT1 Knockdown Prevents Glucose Fluctuation-Induced Apoptosis of Cardiomyocytes through Attenuating Oxidative Stress and Mitochondrial Dysfunction

Researchers investigated the role of sodium‑glucose cotransporter 1 (SGLT1) in rat H9c2 cardiomyocytes subjected to glucose fluctuation and the underlying mechanisms. They indicated that SGLT1 knockdown was able to restore cell proliferation and suppress cytotoxicity induced by glucose fluctuation.
[Biochemistry and Cell Biology]

Abstract

SKELETAL MUSCLE CELLS

Muscle Progenitor Specification and Myogenic Differentiation Are Associated with Changes in Chromatin Topology

Scientists identified key promoter-enhancer interaction motifs, namely, cliques and networks, and interactions that were dependent on Pax7 binding. Remarkably, Pax7 bound to a majority of super-enhancers, and together with a cadre of interacting transcription factors, assembled feed-forward regulatory loops.
[Nature Communications]

Full Article

SMOOTH MUSCLE CELLS

FFAR1 Activation Attenuates Histamine-Induced Myosin Light Chain Phosphorylation and Cortical Tension Development in Human Airway Smooth Muscle Cells

Activation of free fatty acid receptors which are G protein-coupled receptors with established (patho)physiological roles in a variety of obesity-related disorders, induce human airway smooth muscle (HASM) cell proliferation and shortening. Scientists report amplified agonist-induced cell shortening in HASM cells obtained from obese lung donors.
[Respiratory Research]

Full Article

Chemokine Mediated Signaling within Arteries Promotes Vascular Smooth Muscle Cell Recruitment

Investigators showed that autocrine cxcl12b/cxcr4 activity led to increased production of the vascular smooth muscle cells chemoattractant ligand pdgfb by endothelial cells in vitro and increased expression of pdgfb by arteries of zebrafish and mice in vivo.
[Communications Biology]

Full Article

REVIEWS

Modeling Multi-Organ Infection by SARS-CoV-2 using Stem Cell Technology

Scientists describe how the contribution of stem-cell-derived culture systems have helped our understanding of SARS-CoV-2 pathogenesis.
[Cell Stem Cell]

Full Article

INDUSTRY AND POLICY NEWS

Sarepta Therapeutics to Share Clinical Update for SRP-5051, its Investigational PPMO for the Treatment of Duchenne Muscular Dystrophy

Sarepta Therapeutics, Inc. will host a webcast and conference call to present interim data from the MOMENTUM study, a multiple-ascending dose clinical trial of SRP-5051 for the treatment of Duchenne muscular dystrophy.
[Sarepta Therapeutics, Inc.]

Press Release

Amicus Therapeutics Initiates Rolling Biologic License Application to the US Food and Drug Administration for AT-GAA in Late-Onset Pompe Disease

Amicus Therapeutics announced the initiation of the rolling Biologics License Application submission to the FDA for AT-GAA, its investigational two-component therapy for the treatment of late onset Pompe disease.
[Amicus Therapeutics]

Press Release

FEATURED EVENT

Endothelial Cell Indoleamine 2, 3-Dioxygenase 1 Alters Cardiac Function Following Myocardial Infarction through Kynurenine

AMPK Regulates Cell Shape of Cardiomyocytes by Modulating Turnover of Microtubules through CLIP‐170

Bioinformatic Analysis of Membrane and Associated Proteins in Murine Cardiomyocytes and Human Myocardium

Oxidized Low-Density Lipoprotein Associates with Ventricular Stress in Young Adults and Triggers Intracellular Ca²⁺ Alterations in Adult Ventricular Cardiomyocytes

Fast-Relaxing Cardiomyocytes Exert a Dominant Role in the Relaxation Behavior of Heterogeneous Myocardium

SGLT1 Knockdown Prevents Glucose Fluctuation-Induced Apoptosis of Cardiomyocytes through Attenuating Oxidative Stress and Mitochondrial Dysfunction

Muscle Progenitor Specification and Myogenic Differentiation Are Associated with Changes in Chromatin Topology

FFAR1 Activation Attenuates Histamine-Induced Myosin Light Chain Phosphorylation and Cortical Tension Development in Human Airway Smooth Muscle Cells

Chemokine Mediated Signaling within Arteries Promotes Vascular Smooth Muscle Cell Recruitment

Modeling Multi-Organ Infection by SARS-CoV-2 using Stem Cell Technology

Sarepta Therapeutics to Share Clinical Update for SRP-5051, its Investigational PPMO for the Treatment of Duchenne Muscular Dystrophy

Amicus Therapeutics Initiates Rolling Biologic License Application to the US Food and Drug Administration for AT-GAA in Late-Onset Pompe Disease

Assisted Circulation

> See All Events

Research Scientist – Smooth Muscle and Enteric Nervous System

PhD Studentship – Inhibiting MicroRNAs to Improve Skeletal Muscle Phenotype in Cardio-Respiratory Disease

Research Professional – Life Sciences

Faculty Member – Bacaner Endowed Chair in Physiology

Postdoctoral Positions – Gene Regulation in Skeletal Muscle Stem Cells and Embryonic Stem Cells

> See All Jobs