| Vol. 5.44 – 14 December, 2020 |
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| Culturing primary mouse cardiomyocytes in lymphatic endothelial cells (LEC)-conditioned medium increased cardiomyocyte proliferation and survival, indicating that LECs produce lymphoangiocrine signals that control cardiomyocyte homeostasis. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The role of cardiac IgE receptor (FcεR1) signaling in pathological cardiac remodeling was explored in vivo by FcεR1 genetic depletion, anti-IgE antibodies, and bone-marrow transplantation. The roles of immunoglobulin E (IgE)-FcεR1 pathway were further evaluated in vitro in primary cultured rat cardiomyocytes and cardiac fibroblasts. [Circulation] |
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| Researchers defined transcriptional consequences of reduced dosage of the congenital heart disease transcription factor, TBX5, in individual cells during cardiomyocyte differentiation from human induced pluripotent stem cells. [Developmental Cell] |
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| Concomitant single-cell ATAC sequencing exposed underlying dynamics of open chromatin landscapes and regenerative gene regulatory networks of diverse cardiac cell types and revealed extracellular mediators of cardiomyocyte proliferation, angiogenesis, and fibroblast activation. [Cell Reports] |
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| Investigators showed that T3 increased the cardiomyocyte endowment of P8 hearts, but the proliferative response was confined to cardiomyocytes of the left ventricular apex. [Scientific Reports] |
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| The authors identified elevated 15-PGDH, the prostaglandin E2 (PGE2)–degrading enzyme, as a hallmark of aged tissues, including skeletal muscle. The resulting reduction in PGE2 signaling was a major contributor to muscle atrophy in aged mice and resulted from 15-PGDH-expressing myofibers and interstitial cells within muscle. [Science] |
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| Investigators utilized single-nucleus RNA-sequencing to determine the extent of transcriptional diversity within multinucleated skeletal myofibers. [Nature Communications] |
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| The authors investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and regenerating muscle using single-nucleus RNA-sequencing of isolated nuclei from muscle fibers. [Nature Communications] |
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| Scientists present complementary tools for cell labeling with transgenic mice and organic dyes that allow high-resolution intravital imaging of the different mural (smooth muscle cells and pericytes) cell subtypes. [Nature Protocols] |
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| Researchers determined the role of Yin Yang 1 (YY1) in vascular smooth muscle cell (VSMC) phenotypic modulation both in vivo and in vitro. They showed that vascular injury in rodent carotid arteries induced YY1 expression along with reduced expression of smooth muscle differentiation markers in the carotids. [Scientific Reports] |
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| Scientists provide a comprehensive account of the current understanding of Fulminant myocarditis pathophysiology and knowledge regarding its etiology, pathophysiology, treatments, and outcomes. [Signal Transduction and Targeted Therapy] |
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| Genentech announced that the FDA has approved a shorter two-hour infusion time for Ocrevus®, dosed twice-yearly for those living with relapsing or primary progressive multiple sclerosis who have not experienced any prior serious infusion reactions. [Genentech] |
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| May 14 – 19, 2021 San Diego, California, United States |
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| University of California, Los Angeles – Los Angeles, California, United States |
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| Mayo Clinic – Rochester, Minnesota, United States |
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| Stanford University – Stanford, California, United States |
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| University of Minnesota Medical School – Minneapolis, Minnesota, United States |
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| National Institute of Arthritis and Musculoskeletal and Skin Diseases – Washington, DC, United States |
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