Muscle Cell News Volume 5.44 | Dec 14 2020

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    2020-14-12 | MUSCN 5.44


    Muscle Cell News by STEMCELL Technologies
    Vol. 5.44 – 14 December, 2020
    TOP STORY

    Lymphoangiocrine Signals Promote Cardiac Growth and Repair

    Culturing primary mouse cardiomyocytes in lymphatic endothelial cells (LEC)-conditioned medium increased cardiomyocyte proliferation and survival, indicating that LECs produce lymphoangiocrine signals that control cardiomyocyte homeostasis.
    [Nature]

    Abstract


    Derive and expand human skeletal muscle progenitors in a serum-free setting using MyoCultâ„¢-SF Expansion Supplement Kit (Human)
    PUBLICATIONSRanked by the impact factor of the journal
    CARDIAC MUSCLE CELLS

    Role of IgE-FcεR1 in Pathological Cardiac Remodeling and Dysfunction

    The role of cardiac IgE receptor (FcεR1) signaling in pathological cardiac remodeling was explored in vivo by FcεR1 genetic depletion, anti-IgE antibodies, and bone-marrow transplantation. The roles of immunoglobulin E (IgE)-FcεR1 pathway were further evaluated in vitro in primary cultured rat cardiomyocytes and cardiac fibroblasts.
    [Circulation]

    Abstract

    Modeling Human TBX5
    Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease

    Researchers defined transcriptional consequences of reduced dosage of the congenital heart disease transcription factor, TBX5, in individual cells during cardiomyocyte differentiation from human induced pluripotent stem cells.
    [Developmental Cell]

    Full ArticleGraphical Abstract

    Cell-Type-Specific
    Gene Regulatory Networks underlying Murine Neonatal Heart Regeneration at Single-Cell Resolution

    Concomitant single-cell ATAC sequencing exposed underlying dynamics of open chromatin landscapes and regenerative gene regulatory networks of diverse cardiac cell types and revealed extracellular mediators of cardiomyocyte proliferation, angiogenesis, and fibroblast activation.
    [Cell Reports]

    Full ArticleGraphical Abstract

    DUSP5
    Expression in Left Ventricular Cardiomyocytes of Young Hearts Regulates Thyroid Hormone (T3)-Induced Proliferative ERK1/2 Signaling

    Investigators showed that T3 increased the cardiomyocyte endowment of P8 hearts, but the proliferative response was confined to cardiomyocytes of the left ventricular apex.
    [Scientific Reports]

    Full Article

    SKELETAL MUSCLE CELLS

    Inhibition
    of Prostaglandin-Degrading Enzyme 15-PGDH Rejuvenates Aged Muscle Mass and Strength

    The authors identified elevated 15-PGDH, the prostaglandin E2 (PGE2)–degrading enzyme, as a hallmark of aged tissues, including skeletal muscle. The resulting reduction in PGE2 signaling was a major contributor to muscle atrophy in aged mice and resulted from 15-PGDH-expressing myofibers and interstitial cells within muscle.
    [Science]

    Abstract

    Single-Nucleus
    RNA-Seq Identifies Transcriptional Heterogeneity in Multinucleated Skeletal Myofibers

    Investigators utilized single-nucleus RNA-sequencing to determine the extent of transcriptional diversity within multinucleated skeletal myofibers.
    [Nature Communications]

    Full Article

    Single-Nucleus
    Transcriptomics Reveals Functional Compartmentalization in Syncytial Skeletal Muscle Cells

    The authors investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and regenerating muscle using single-nucleus RNA-sequencing of isolated nuclei from muscle fibers.
    [Nature Communications]

    Full ArticlePress Release

    SMOOTH MUSCLE CELLS

    Imaging and Optogenetic Modulation of Vascular Mural Cells in the Live Brain

    Scientists present complementary tools for cell labeling with transgenic mice and organic dyes that allow high-resolution intravital imaging of the different mural (smooth muscle cells and pericytes) cell subtypes.
    [Nature Protocols]

    Abstract

    YY1
    Directly Interacts with Myocardin to Repress the Triad Myocardin/SRF/CArG Box-Mediated Smooth Muscle Gene Transcription during Smooth Muscle Phenotypic Modulation

    Researchers determined the role of Yin Yang 1 (YY1) in vascular smooth muscle cell (VSMC) phenotypic modulation both in vivo and in vitro. They showed that vascular injury in rodent carotid arteries induced YY1 expression along with reduced expression of smooth muscle differentiation markers in the carotids.
    [Scientific Reports]

    Full Article


    hPSC-derived cardiomycyte generated by STEMdiffâ„¢ Cardiomyocyte Differentiation Kit
    REVIEWS

    Fulminant
    Myocarditis: A Comprehensive Review from Etiology to Treatments and Outcomes

    Scientists provide a comprehensive account of the current understanding of Fulminant myocarditis pathophysiology and knowledge regarding its etiology, pathophysiology, treatments, and outcomes.
    [Signal Transduction and Targeted Therapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    FDA
    Approves Genentech’s Ocrevus (Ocrelizumab) Shorter Two-Hour Infusion for Relapsing and Primary Progressive Multiple Sclerosis

    Genentech announced that the FDA has approved a shorter two-hour infusion time for Ocrevus®, dosed twice-yearly for those living with relapsing or primary progressive multiple sclerosis who have not experienced any prior serious infusion reactions.
    [Genentech]

    Press Release

    FEATURED EVENT

    American Thoracic Society International Conference 2021

    May 14 – 19, 2021
    San Diego, California, United States


    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral
    Position – Drug Development

    University of California, Los Angeles – Los Angeles, California, United States

    Research
    Scientist – Smooth Muscle and Enteric Nervous System

    Mayo Clinic – Rochester, Minnesota, United States

    Research Professional – Life Sciences

    Stanford University – Stanford, California, United States

    Faculty
    Member – Bacaner Endowed Chair in Physiology

    University of Minnesota Medical School – Minneapolis, Minnesota, United States

    Postdoctoral
    Positions – Gene Regulation in Skeletal Muscle Stem Cells and Embryonic Stem Cells

    National Institute of Arthritis and Musculoskeletal and Skin Diseases – Washington, DC, United States

    > See All Jobs

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