Muscle Cell News Volume 6.01 | Jan 11 2021

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    Justin.choi
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    2020-11-01 | MUSCN 6.01


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.01 – 11 January, 2021
    TOP STORY

    Mirroring
    Action Potentials: Label‐Free, Accurate, and Noninvasive Electrophysiological Recordings of Human‐Derived Cardiomyocytes

    A new approach for recording intracellular signals of outstanding quality and with noninvasiveness is introduced. By taking profit of the concept of mirror charge in classical electrodynamics, the new proposed device transduced cell ionic currents into mirror charges in a microfluidic chamber, thus realizing a virtual mirror cell.
    [Advanced Materials]

    Full Article


    Derive and expand human skeletal muscle progenitors in a serum-free setting using MyoCult™-SF Expansion Supplement Kit (Human)
    PUBLICATIONSRanked by the impact factor of the journal
    CARDIAC MUSCLE CELLS

    ERG1
    Plays an Essential Role in Rat Cardiomyocyte Fate Decision by Mediating AKT Signaling

    Using the rat embryonic stem cells model, investigators showed that ERG1 was crucial in cardiomyocyte lineage commitment via interactions with integrin β1.
    [Stem Cells]

    Abstract

    SKELETAL MUSCLE CELLS

    The
    Hox Transcription Factor Ubx Ensures Somatic Myogenesis by Suppressing the Mesodermal Master Regulator Twist

    Using the Drosophila mesoderm as a model and a comparative genomic approach, the authors identified the Hox transcription factor Ultrabithorax (Ubx) to be critical for the repression of the master regulator Twist.
    [Cell Reports]

    Full ArticleGraphical Abstract

    ARHGEF3
    Regulates Skeletal Muscle Regeneration and Strength through Autophagy

    Scientists report ARHGEF3’s role in skeletal muscle regeneration revealed by ARHGEF3-KO mice. These mice exhibited indiscernible phenotype under basal conditions.
    [Cell Reports]

    Full ArticleGraphical Abstract

    PDGFRα
    Mediated Survival of Myofibroblasts Inhibit Satellite Cell Proliferation during Aberrant Regeneration of Lacerated Skeletal Muscle

    Investigators showed that the decline in myofibroblasts’ number through inhibition of PDGFRα signaling consequently promoted proliferation of the satellite cells and exhibited improved skeletal muscle remodeling.
    [Scientific Reports]

    Full Article

    Effect
    of Hydrogen Peroxide Concentration on the Maintenance and Differentiation of Cultured Skeletal Muscle Cells

    Researchers studied the effects of hydrogen peroxide (H2O2) on the differentiation and maintenance of C2C12 myoblasts. The effects of H2O2 were evaluated by cell viability, total protein concentration, the relative amount of muscle-related proteins, sarcomere structure, and active tension generation.
    [Journal of Bioscience and Bioengineering]

    Abstract

    SMOOTH MUSCLE CELLS

    Lnc-Rps4l-Encoded Peptide RPS4XL Regulates RPS6 Phosphorylation Inhibits the Proliferation of Pulmonary Artery Smooth Muscle Cells Caused by Hypoxia

    Scientists hypothesized in this study that an lnc-Rps4l-encoded peptide is involved in hypoxic induced pulmonary artery smooth muscle cells (PASMCs) proliferation. The presence of peptide RPS4XL encoded by lnc-Rps4l in PASMCs under hypoxic conditions were confirmed by bioinformatics, immunofluorescence and immunohistochemistry.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Endothelial
    Cells Control Vascular Smooth Muscle Cell Cholesterol Levels by Regulating 24-Dehydrocholesterol Reductase Expression

    The authors investigated changes of the vascular smooth muscle cell (VSMC) transcriptome by utilizing 3D human vascular organoids organized as a core of VSMCs enclosed by a monolayer of endothelial cells.
    [Experimental Cell Research]

    Abstract

    Molecular
    Expression and Functional Features of Kv7 Channels in Human Prostate Smooth Muscle

    In human prostatic smooth muscle cells, KCNQ4, KCNQ5, and KCNE4 isoforms were predominantly expressed, while KCNQ1, KCNQ5, and KCNE3 isoforms were the most abundantly expressed in human prostatic tissues.
    [Andrology]

    Abstract


    hPSC-derived cardiomycyte generated by STEMdiff™ Cardiomyocyte Differentiation Kit
    REVIEWS

    Current
    Perspectives on Obesity and Skeletal Muscle Contractile Function in Older Adults

    Investigators provide an update on the current knowledge related to obesity and skeletal muscle contractile function and highlight a number of questions to address potential etiologic mechanisms as well as intervention strategies, which may help advance the understanding of how physical performance can be improved among obese older adults.
    [Journal of Applied Physiology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Pfizer
    Doses First Participant in Phase III Study for Duchenne Muscular Dystrophy Investigational Gene Therapy

    Pfizer Inc. announced that the first participant has been dosed in the Phase III CIFFREO study, which will evaluate the efficacy and safety of investigational gene therapy candidate PF-06939926 in boys with Duchenne muscular dystrophy.
    [Pfizer Inc.]

    Press Release

    Prilenia
    Announces First Patient Enrolled for Pridopidine Phase II/III Platform Trial for ALS

    Prilenia Therapeutics B.V. announced the enrollment of the first participant for treatment with pridopidine in the pivotal HEALEY ALS Platform Trial.
    [Prilenia Therapeutics B.V.]

    Press Release

    FEATURED EVENT

    Wisconsin
    Stem Cell Symposium: The Single Cell Revolution in Stem Cells

    April 14, 2021
    Madison, Wisconsin, United States


    > See All Events

    JOB OPPORTUNITIES

    Scientific
    Communities & Communications Specialist

    STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada

    Professor
    or Associate Professor – Rheumatology

    The University of Utah School of Medicine – Salt Lake City, Utah, United States

    PhD
    Studentships – Spinal Muscular Atrophy

    Hannover Medical School – Hannover, Germany

    Postdoctoral
    Position – Drug Development

    University of California, Los Angeles – Los Angeles, California, United States

    Research
    Scientist – Smooth Muscle and Enteric Nervous System

    Mayo Clinic – Rochester, Minnesota, United States

    Research Professional – Life Sciences

    Stanford University – Stanford, California, United States

    Postdoctoral
    Positions – Gene Regulation in Skeletal Muscle Stem Cells and Embryonic Stem Cells

    National Institute of Arthritis and Musculoskeletal and Skin Diseases – Washington, DC, United States

    > See All Jobs

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