Muscle Cell News Volume 6.03 | Jan 25 2021

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    2020-25-01 | MUSCN 6.03

    Muscle Cell News by STEMCELL Technologies

    Vol. 6.03 – 25 January, 2021

    TOP STORY

    Caveolin3
    Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes

    Scientists demonstrated the physiological relevance and loss-of-function mechanism of a novel Caveolin3 interactor in gene-edited human iPSC-cardiomyocytes.
    [Circulation Research]

    Abstract


    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart

    PUBLICATIONSRanked by the impact factor of the journal

    CARDIAC MUSCLE CELLS

    TEAD1
    Protects against Necroptosis in Postmitotic Cardiomyocytes through Regulation of Nuclear DNA-Encoded Mitochondrial Genes

    The authors reported that TEAD1 was required for postmitotic cardiomyocyte (CM) survival. They found that adult mice with ubiquitous or CM-specific loss of Tead1 presented with a rapid lethality due to an acute-onset dilated cardiomyopathy.
    [Cell Death & Differentiation]

    Abstract

    Compartmentation of β2‐Adrenergic
    Receptor Stimulated cAMP Responses by Phosphodiesterases Type 2 and 3 in Cardiac Ventricular Myocytes

    Researchers tested the hypothesis that β2‐adrenergic receptor stimulation produces a cAMP signal that is unable to reach sarco/endoplasmic reticulum Ca2+‐ATPase 2, and determined what role, if any, phosphodiesterase activity plays in this compartmentation.
    [British Journal of Pharmacology]

    Abstract

    Impaired In Vitro
    Growth Response of Plasma-Treated Cardiomyocytes Predicts Poor Outcome in Patients with Transthyretin Amyloidosis

    Scientists analyzed cellular hypertrophy after phenylephrine stimulation in vitro in the presence of patient plasma and correlated the cellular growth response with phenotype and prognosis.
    [Clinical Research in Cardiology]

    Full Article

    Pharmacological
    Protein Kinase C Modulators Reveal a Pro-Hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

    Researchers investigated the effects of two different types of protein kinase C (PKC) activators, the isophthalate derivative HMI-1b11 and bryostatin-1, on cardiomyocyte hypertrophy and elucidated the role of cPKCs and nPKCs in endothelin-1-induced hypertrophy in vitro.
    [Frontiers in Pharmacology]

    Full Article

    Metformin
    Relieves H/R-Induced Cardiomyocyte Injury through miR-19a/ACSL Axis – Possible Therapeutic Target for Myocardial I/R Injury

    Biological function experiments in vitro revealed that hypoxia/reoxygenation markedly declined the viability and elevated the apoptosis of AC16 cells, while metformin could significantly mitigate these effects.
    [Toxicology and Applied Pharmacology]

    Abstract

    SKELETAL MUSCLE CELLS

    Myomerger
    Promotes Fusion Pore by Elastic Coupling between Proximal Membrane Leaflets and Hemifusion Diaphragm

    Researchers showed that Myomerger ectodomain generated positive spontaneous curvature of lipid monolayers. They substantiated the mechanism by experiments on myoblast fusion and influenza hemagglutinin-mediated cell fusion.
    [Nature Communications]

    Full Article

    NAD+
    Boosting Reduces Age-Associated Amyloidosis and Restores Mitochondrial Homeostasis in Muscle

    Investigators showed accumulation of amyloid-like deposits and mitochondrial dysfunction during natural aging in the body wall muscle of C. elegans, in human primary myotubes, and in mouse skeletal muscle, partially phenocopying inclusion body myositis.
    [Cell Reports]

    Full Article

    SMOOTH MUSCLE CELLS

    Single Cell Transcriptomic Analysis Identifies Novel Vascular Smooth Muscle Subsets under High Hydrostatic Pressure

    The authors constructed a high-hydrostatic-pressure cell-culture system to imitate constant hypertension and identified novel molecular classifications of human aortic smooth muscle cells by single-cell transcriptome analysis.
    [Science China-Life Sciences]

    Abstract


    Generate functional cardiomyocytes from hPSCs with the STEMdiff™ Cardiomyocyte Differentiation Kit

    REVIEWS

    Pathophysiology of Sepsis-Induced Cardiomyopathy

    Researchers explore the definition, epidemiology, diagnosis and pathophysiology of septic cardiomyopathy, with an emphasis on how best to interpret this condition in the clinical context.
    [Nature Reviews Cardiology]

    Abstract

    Considerations for the Bioengineering of Advanced Cardiac In Vitro
    Models of Myocardial Infarction

    Scientists highlight the major features typical of a heart attack while comparing current in vitro, ex vivo, and in vivo models. This information has the potential to further guide in developing novel advanced in vitro cardiac models of ischemia/reperfusion injury.
    [Small]

    Abstract

    Using
    Patient-Derived Induced Pluripotent Stem Cells to Identify Risks of Drug-Induced Cardiotoxicity

    The authors discuss the current use of patient-specific induced pluripotent stem cells in identifying populations who are at risk to drug-induced cardiotoxicity and their potential applications in future precision medicine practice.
    [Arteriosclerosis Thrombosis and Vascular Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Dr. Artero’s Lab Researching on MicroRNA-Based Treatments for Myotonic Dystrophy Type 1 by Translational Genomics Group

    Translational Genomics Group has announced the research on the development of novel myotonic dystrophy type 1 therapies based on recent new knowledge on microRNA class molecules.
    [Translational Genomics Group (PR Newswire Association, LLC.)]

    Press Release

    FEATURED EVENT

    Lipidomics of Health and Disease

    March 24 – 26, 2021
    Virtual


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    JOB OPPORTUNITIES

    Research
    Assistant – Myotonic Dystrophy

    Baylor College of Medicine – Houston, Texas, United States

    Scientific
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    STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada

    Professor or Associate Professor – Rheumatology

    The University of Utah School of Medicine – Salt Lake City, Utah, United States

    Research
    Scientist – Smooth Muscle and Enteric Nervous System

    Mayo Clinic – Rochester, Minnesota, United States

    Research Professional – Life Sciences

    Stanford University – Stanford, California, United States

    Postdoctoral
    Positions – Gene Regulation in Skeletal Muscle Stem Cells and Embryonic Stem Cells

    National Institute of Arthritis and Musculoskeletal and Skin Diseases – Washington, DC, United States

    > See All Jobs

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