| Vol. 6.03 – 25 January, 2021 |
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| Scientists demonstrated the physiological relevance and loss-of-function mechanism of a novel Caveolin3 interactor in gene-edited human iPSC-cardiomyocytes. [Circulation Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported that TEAD1 was required for postmitotic cardiomyocyte (CM) survival. They found that adult mice with ubiquitous or CM-specific loss of Tead1 presented with a rapid lethality due to an acute-onset dilated cardiomyopathy. [Cell Death & Differentiation] |
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| Researchers tested the hypothesis that β2‐adrenergic receptor stimulation produces a cAMP signal that is unable to reach sarco/endoplasmic reticulum Ca2+‐ATPase 2, and determined what role, if any, phosphodiesterase activity plays in this compartmentation. [British Journal of Pharmacology] |
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| Scientists analyzed cellular hypertrophy after phenylephrine stimulation in vitro in the presence of patient plasma and correlated the cellular growth response with phenotype and prognosis. [Clinical Research in Cardiology] |
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| Researchers investigated the effects of two different types of protein kinase C (PKC) activators, the isophthalate derivative HMI-1b11 and bryostatin-1, on cardiomyocyte hypertrophy and elucidated the role of cPKCs and nPKCs in endothelin-1-induced hypertrophy in vitro. [Frontiers in Pharmacology] |
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| Biological function experiments in vitro revealed that hypoxia/reoxygenation markedly declined the viability and elevated the apoptosis of AC16 cells, while metformin could significantly mitigate these effects. [Toxicology and Applied Pharmacology] |
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| Researchers showed that Myomerger ectodomain generated positive spontaneous curvature of lipid monolayers. They substantiated the mechanism by experiments on myoblast fusion and influenza hemagglutinin-mediated cell fusion. [Nature Communications] |
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| Investigators showed accumulation of amyloid-like deposits and mitochondrial dysfunction during natural aging in the body wall muscle of C. elegans, in human primary myotubes, and in mouse skeletal muscle, partially phenocopying inclusion body myositis. [Cell Reports] |
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| | The authors constructed a high-hydrostatic-pressure cell-culture system to imitate constant hypertension and identified novel molecular classifications of human aortic smooth muscle cells by single-cell transcriptome analysis. [Science China-Life Sciences] |
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| Researchers explore the definition, epidemiology, diagnosis and pathophysiology of septic cardiomyopathy, with an emphasis on how best to interpret this condition in the clinical context. [Nature Reviews Cardiology] |
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| Scientists highlight the major features typical of a heart attack while comparing current in vitro, ex vivo, and in vivo models. This information has the potential to further guide in developing novel advanced in vitro cardiac models of ischemia/reperfusion injury. [Small] |
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| The authors discuss the current use of patient-specific induced pluripotent stem cells in identifying populations who are at risk to drug-induced cardiotoxicity and their potential applications in future precision medicine practice. [Arteriosclerosis Thrombosis and Vascular Biology] |
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| Translational Genomics Group has announced the research on the development of novel myotonic dystrophy type 1 therapies based on recent new knowledge on microRNA class molecules. [Translational Genomics Group (PR Newswire Association, LLC.)] |
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| March 24 – 26, 2021 Virtual |
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| Baylor College of Medicine – Houston, Texas, United States |
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| STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| The University of Utah School of Medicine – Salt Lake City, Utah, United States |
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| Mayo Clinic – Rochester, Minnesota, United States |
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| Stanford University – Stanford, California, United States |
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| National Institute of Arthritis and Musculoskeletal and Skin Diseases – Washington, DC, United States |
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