Muscle Cell News Volume 6.05 | Feb 8 2021

May 12, 2022

2020-08-02 | MUSCN 6.05

Muscle Cell News by STEMCELL Technologies

Vol. 6.05 – 8 February, 2021

TOP STORY

Microfibrillar-Associated Protein 4 Regulates Stress-Induced Cardiac Remodeling

Scientists identified a novel role for a non-myocyte-derived and TGFbeta1-induced extracellular matrix protein microfibrillar-associated protein 4 in the pathophysiology of cardiac remodeling.
[Circulation Research]

Abstract

Derive and expand human skeletal muscle progenitors in a serum-free setting using MyoCult™-SF Expansion Supplement Kit (Human)

PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

GRK5 Is a Regulator of Fibroblast Activation and Cardiac Fibrosis

Researchers demonstrated using adult cardiac fibroblasts that genetic deletion of G protein-coupled receptor kinase 5 inhibited angiotensin II-mediated fibroblast activation.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Targeting OCT3 Attenuates Doxorubicin-Induced Cardiac Injury

Using stem-cell–derived cardiomyocytes from patients receiving doxorubicin, the authors probed the transcriptomic landscape of solute carriers and identified organic cation transporter 3 as a critical transporter regulating the cardiac accumulation of doxorubicin.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Rictor/mTORC2 Involves Mitochondrial Function in ES Cells Derived Cardiomyocytes via Mitochondrial Connexin 43

Investigators used the model of cardiomyocyte differentiation from mouse embryonic stem (ES) cells to elucidate the mechanisms for the mitochondrial damage in ES cell-derived cardiomyocytes after knockdown of Rictor.
[Acta Pharmacologica Sinica]

Full Article

Elevated Myocardial Fructose and Sorbitol Levels Are Associated with Diastolic Dysfunction in Diabetic Patients, and Cardiomyocyte Lipid Inclusions In Vitro

Scientists clinically evaluated links between myocardial fructose and sorbitol levels with evidence of cardiac dysfunction, and to experimentally assess the cardiomyocyte mechanisms involved in mediating the metabolic effects of elevated fructose.
[Nutrition & Diabetes]

Full Article

SKELETAL MUSCLE CELLS

TGFβ Signaling Acts as a Molecular Brake of Myoblast Fusion

Researchers uncovered, through high-throughput in vitro assays and in vivo studies in the chicken embryo, that TGFβ signaling acted specifically and uniquely as a molecular brake on muscle fusion.
[Nature Communications]

Full Article

TGFβ Signaling Curbs Cell Fusion and Muscle Regeneration

Investigators showed that transforming growth factor beta (TGFβ) pathway was active in adult muscle cells throughout fusion. They found TGFβ signaling reduced cell fusion, regardless of the cells’ ability to move and establish cell-cell contacts.
[Nature Communications]

Full Article

FoxP1 Is a Transcriptional Repressor Associated with Cancer Cachexia that Induces Skeletal Muscle Wasting and Weakness

Researchers investigated the biological significance of Forkhead box P1, a transcriptional repressor that they demonstrated is up‐regulated in skeletal muscle in multiple models of cancer cachexia and in cachectic cancer patients.
[Journal of Cachexia Sarcopenia and Muscle]

Full Article

Mechano-Chemical Enforcement of Tendon Apical ECM into Nano-Filaments during Drosophila Flight Muscle Development

Investigators showed that Dumpy underwent filamentous conversion in response to the tension increment during indirect flight muscle development.
[Current Biology]

Full Article Graphical Abstract

Reduced rDNA Transcription Diminishes Skeletal Muscle Ribosomal Capacity and Protein Synthesis in Cancer Cachexia

The authors investigated whether muscle loss in a preclinical model of ovarian cancer was associated with a reduction in ribosomal capacity and was a consequence of impaired ribosomal DNA (rDNA) transcription.
[FASEB Journal]

Abstract

SMOOTH MUSCLE CELLS

Essential Role of Smooth Muscle Rac1 in Severe Asthma-Associated Airway Remodeling

Researchers demonstrated that Rac1 is overactive in the airways of patients with severe asthma and is essential for airway smooth muscle cell proliferation.
[Thorax]

Full Article

REVIEWS

Recent Progress in Induced Pluripotent Stem Cell-Derived 3D Cultures for Cardiac Regeneration

Future research optimizing maturation and integration of induced pluripotent stem cell-derived cardiomyocytes is paramount for cardiac cell therapy to attain clinical use. The authors review the state of the art and the different approaches to constructing these 3D transplantable structures.
[Cell and Tissue Research]

Abstract

INDUSTRY AND POLICY NEWS

Adjuvant Treatment with Opdivo (Nivolumab) Demonstrates Statistically Significant and Clinically Meaningful Improvement in Disease-Free Survival in Patients with Muscle-Invasive Urothelial Carcinoma in Phase III CheckMate -274 Trial

Bristol Myers Squibb announced results from the Phase III CheckMate -274 trial, which showed that Opdivo significantly improved disease-free survival as an adjuvant treatment across all randomized patients with surgically resected, high-risk muscle-invasive urothelial carcinoma and in the subgroup of patients whose tumors express PD-L1 ≥1%, meeting both of the study’s primary endpoints.
[Bristol Myers Squibb]

Press Release

FEATURED EVENT

Microfibrillar-Associated Protein 4 Regulates Stress-Induced Cardiac Remodeling

GRK5 Is a Regulator of Fibroblast Activation and Cardiac Fibrosis

Targeting OCT3 Attenuates Doxorubicin-Induced Cardiac Injury

Rictor/mTORC2 Involves Mitochondrial Function in ES Cells Derived Cardiomyocytes via Mitochondrial Connexin 43

Elevated Myocardial Fructose and Sorbitol Levels Are Associated with Diastolic Dysfunction in Diabetic Patients, and Cardiomyocyte Lipid Inclusions In Vitro

TGFβ Signaling Acts as a Molecular Brake of Myoblast Fusion

TGFβ Signaling Curbs Cell Fusion and Muscle Regeneration

FoxP1 Is a Transcriptional Repressor Associated with Cancer Cachexia that Induces Skeletal Muscle Wasting and Weakness

Mechano-Chemical Enforcement of Tendon Apical ECM into Nano-Filaments during Drosophila Flight Muscle Development

Reduced rDNA Transcription Diminishes Skeletal Muscle Ribosomal Capacity and Protein Synthesis in Cancer Cachexia

Essential Role of Smooth Muscle Rac1 in Severe Asthma-Associated Airway Remodeling

Recent Progress in Induced Pluripotent Stem Cell-Derived 3D Cultures for Cardiac Regeneration

Adjuvant Treatment with Opdivo (Nivolumab) Demonstrates Statistically Significant and Clinically Meaningful Improvement in Disease-Free Survival in Patients with Muscle-Invasive Urothelial Carcinoma in Phase III CheckMate -274 Trial

Muscle: Excitation-Contraction Coupling

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PhD Position – Muscle Self-Organization

Researcher III – Cardiovascular Disease

Research Assistant – Myotonic Dystrophy

Professor or Associate Professor – Rheumatology

Research Professional – Life Sciences

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