Muscle Cell News Volume 6.06 | Feb 22 2021

May 12, 2022

2020-22-02 | MUSCN 6.06

Muscle Cell News by STEMCELL Technologies

Vol. 6.06 – 22 February, 2021

TOP STORY

Macrophages Provide a Transient Muscle Stem Cell Niche via NAMPT Secretion

Researchers used muscle injury models in zebrafish to systematically capture the interactions between satellite cells and the innate immune system after injury, in real time, throughout the repair process.
[Nature]

Abstract

Generate functional cardiomyocytes from hPSCs with the STEMdiff™ Cardiomyocyte Differentiation Kit

PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

Exercise Triggers CAPN1-Mediated AIF Truncation, Inducing Myocyte Cell Death in Arrhythmogenic Cardiomyopathy

When cardiomyocytes differentiated from Dsg2^mut/mut embryonic stem cells were challenged with β-adrenergic stimulation, calpain-1 (CAPN1) inhibition attenuated CAPN1-induced AIF truncation.
[Science Translational Medicine]

Abstract

The Double Face of miR-320: Cardiomyocytes-Derived miR-320 Deteriorated While Fibroblasts-Derived miR-320 Protected against Heart Failure Induced by Transverse Aortic Constriction

A Langendorff system was applied to isolate cardiomyocytes and cardiac fibroblasts from transverse aortic constriction-induced mice.
[Signal Transduction and Targeted Therapy]

Full Article

The Mechanosensitive Piezo1 Channel Mediates Heart Mechano-Chemo Transduction

Researchers showed that the mechanically activated Piezo1 channel converted mechanical stretch of cardiomyocytes into Ca²⁺ and reactive oxygen species signaling, which critically determined the mechanical activity of the heart.
[Nature Communications]

Full Article

Dynamic Effects of Genetic Variation on Gene Expression Revealed following Hypoxic Stress in Cardiomyocytes

To study inter-individual differences in response to hypoxia, scientists established an in vitro model of induced pluripotent stem cell-derived cardiomyocytes from 15 individuals.
[eLife]

Abstract

SKELETAL MUSCLE CELLS

Functional Skeletal Muscle Regeneration with Thermally Drawn Porous Fibers and Reprogrammed Muscle Progenitors for Volumetric Muscle Injury

Muscle extracellular matrix (MEM) and induced skeletal myogenic progenitor cells (iMPCs) were integrated within thermally drawn fiber based microchannel scaffolds. The microchannel fibers decorated with MEM enhanced differentiation and maturation of iMPCs.
[Advanced Materials]

Abstract

Tissue Damage Induces a Conserved Stress Response that Initiates Quiescent Muscle Stem Cell Activation

Using quiescent muscle stem cells as a paradigm of cell activation following injury, scientists captured early cell activation following muscle injury and found that an essential ERK1/2 primary proliferation signal preceded initiation of the Notch-regulated myogenic program.
[Cell Stem Cell]

Abstract Graphical Abstract

Autophagy-Dependent Regulation of Skeletal Muscle Regeneration and Strength by a RHOGEF

Researchers revealed that ARHGEF3 negatively regulated skeletal muscle autophagy during injury-induced regeneration and normal aging.
[Autophagy]

Abstract

Gli1 Defines a Subset of Fibroadipogenic Progenitors that Promote Skeletal Muscle Regeneration with Less Fat Accumulation

Using a lineage tracing mouse model, the authors demonstrated that Gli1 marks a small subset of muscle‐resident fibro‐adipogenic progenitors with elevated Hedgehog signaling.
[Journal of Bone and Mineral Research]

Abstract

SMOOTH MUSCLE CELLS

Cezanne Is a Critical Regulator of Pathological Arterial Remodeling by Targeting β-Catenin Signaling

Researchers examined the pathological role of Cezanne in vascular smooth muscle cell pathology and arterial remodeling.
[Cardiovascular Research]

Abstract Graphical Abstract

Inhibition of miR-135a-5p Attenuates Vascular Smooth Muscle Cell Proliferation and Vascular Remodeling in Hypertensive Rats

Scientists determined the roles and mechanisms of miR-135a-5p intervention in attenuating vascular smooth muscle cell proliferation and vascular remodeling in spontaneously hypertensive rats
[Acta Pharmacologica Sinica]

Abstract

Multiple Cell Types Contribute to the Atherosclerotic Lesion Fibrous Cap by PDGFRβ and Bioenergetic Mechanisms

Researchers showed that smooth muscle cell (SMC)-specific knockout of the Pdgfrb gene, which encodes platelet-derived growth factor receptor beta (PDGFRβ), in Apoe^−/− mice fed a Western diet for 18 weeks resulted in brachiocephalic artery lesions nearly devoid of SMCs but with no changes in lesion size, remodelling or indices of stability, including the percentage of ACTA2⁺ fibrous cap cells.
[Nature Metabolism]

Abstract

Virtual Conference Exhibition: Pluripotent Stem Cells

REVIEWS

Immunomodulation for Optimal Cardiac Regeneration: Insights from Comparative Analyses

Comparing the human heart with those of animal models that are capable of cardiac regeneration reveals key differences in the innate and adaptive immune responses to myocardial infarction.
[npj Regenerative Medicine]

Full Article

Recent Progress in Induced Pluripotent Stem Cell-Derived 3D Cultures for Cardiac Regeneration

Future research optimizing maturation and integration of induced pluripotent stem cell-derived cardiomyocytes is paramount for cardiac cell therapy to attain clinical use. Researchers review the state of the art and the different approaches to constructing these 3D transplantable structures.
[Cell and Tissue Research]

Abstract

INDUSTRY AND POLICY NEWS

Duchenne UK and Parent Project Muscular Dystrophy Award $350,000 to Address Immunological Challenges of Gene Therapy in Duchenne Muscular Dystrophy

Parent Project Muscular Dystrophy and Duchenne UK announced Professor Kanneboyina Nagaraju at Binghamton, the State University of New York, as the recipient of a Joint Research Grant Call of 2020. The full title of the research project is “Targeting the innate immune system to block acute inflammatory and chronic immune response to transgene and adeno-associated virus vector in DMD”.
[Parent Project Muscular Dystrophy]

Press Release

FEATURED EVENT

Macrophages Provide a Transient Muscle Stem Cell Niche via NAMPT Secretion

Exercise Triggers CAPN1-Mediated AIF Truncation, Inducing Myocyte Cell Death in Arrhythmogenic Cardiomyopathy

The Double Face of miR-320: Cardiomyocytes-Derived miR-320 Deteriorated While Fibroblasts-Derived miR-320 Protected against Heart Failure Induced by Transverse Aortic Constriction

The Mechanosensitive Piezo1 Channel Mediates Heart Mechano-Chemo Transduction

Dynamic Effects of Genetic Variation on Gene Expression Revealed following Hypoxic Stress in Cardiomyocytes

Functional Skeletal Muscle Regeneration with Thermally Drawn Porous Fibers and Reprogrammed Muscle Progenitors for Volumetric Muscle Injury

Tissue Damage Induces a Conserved Stress Response that Initiates Quiescent Muscle Stem Cell Activation

Autophagy-Dependent Regulation of Skeletal Muscle Regeneration and Strength by a RHOGEF

Gli1 Defines a Subset of Fibroadipogenic Progenitors that Promote Skeletal Muscle Regeneration with Less Fat Accumulation

Cezanne Is a Critical Regulator of Pathological Arterial Remodeling by Targeting β-Catenin Signaling

Inhibition of miR-135a-5p Attenuates Vascular Smooth Muscle Cell Proliferation and Vascular Remodeling in Hypertensive Rats

Multiple Cell Types Contribute to the Atherosclerotic Lesion Fibrous Cap by PDGFRβ and Bioenergetic Mechanisms

Immunomodulation for Optimal Cardiac Regeneration: Insights from Comparative Analyses

Recent Progress in Induced Pluripotent Stem Cell-Derived 3D Cultures for Cardiac Regeneration

Duchenne UK and Parent Project Muscular Dystrophy Award $350,000 to Address Immunological Challenges of Gene Therapy in Duchenne Muscular Dystrophy

Intrinsic and Extrinsic Control of Myogenesis under Physiological and Pathological Conditions

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Research Associate/Senior Research Associate – Tissue Engineering for Artificial Muscle Integration

PhD Position – Muscle Self-Organization

Researcher III – Cardiovascular Disease

Research Assistant – Myotonic Dystrophy

Professor or Associate Professor – Rheumatology

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