 | | Vol. 6.08 – 8 March, 2021 |
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| Scientists investigated the role of succinate and succinate dehydrogenase inhibition in regulation of postnatal cardiomyocyte cell cycle activity and heart regeneration.
[Circulation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Functional validation studies of sex steroids implicated in cardiac maturation were performed in human pluripotent stem cell-derived cardiac organoids and mice.
[Circulation] |
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| Investigators established a preclinical toxicology model using same-origin human pluripotent stem cell-differentiated cardiomyocytes and endothelial cells.
[Acta Pharmacologica Sinica] |
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| Researchers found that the levels of the ubiquitin ligase UBR4 increased in skeletal muscle with aging, and that UBR4 increased the proteolytic activity of the proteasome.
[Nature Communications] |
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| The authors showed that autotaxin (Atx) expression and activity was required for satellite cell differentiation. Conditional ablation of Atx or its pharmacological inhibition impaired muscle repair.
[Cell Reports] |
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| Investigators evaluated the functional role of hnRNP L in normal and myotonic dystrophy type 1 (DM1) muscle cells. They sought to test if modulation of hnRNP L expression affected DM1 splicing targets and myogenic outcomes.
[Muscle & Nerve] |
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| Researchers showed evidence for the involvement of a specific circular RNA known as circ-Calm4 in pulmonary hypertension and the underlying signaling pathway in pyroptosis.
[Arteriosclerosis Thrombosis and Vascular Biology] |
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| The authors examined the role of the intermediate‐conductance Ca2+‐activated K+ channel in the matrix stiffness regulation of vascular smooth muscle cell proliferation by growing A7r5 cells on soft and stiff polydimethylsiloxane substrates with stiffness close to these of arteries under physiological and pathological conditions, respectively.
[Journal of Cellular Physiology] |
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| Researchers generated hypoxia-inducible factor 2α (HIF2A) gain-of-function induced pluripotent stem cells and differentiated them into endothelial cells and smooth muscle cells.
[iScience] |
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| The authors review the current understanding of muscle stem cell quiescence and highlight recently discovered molecular markers, which differentiate depth of quiescence and influence self-renewal capacity.
[Trends in Cell Biology] |
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| BERLIN HEALS announced results of a first-in-human study published in ESC Heart Failure, in patients with dilated cardiomyopathy for its proprietary C-MIC device.
[BERLIN HEALS (GlobeNewswire, Inc.)] |
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| April 26 – 30, 2021
Virtual |
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| | University of Southern Denmark – Odense M, Denmark |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | The University of Utah School of Medicine – Salt Lake City, Utah, United States |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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