 | | Vol. 6.10 – 22 March, 2021 |
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| To identify mechanisms and cardio-protective drugs, scientists used a state-of-the-art pipeline combining human cardiac organoids with phosphoproteomics and single nuclei RNA sequencing.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| | Epicardial-derived cardiac fibroblasts and epithelial cells expressed paracrine factors, including TGFβ1 and FGFs, which mediated epithelial-to-mesenchymal transition, and contributed to the pathogenesis of myocardial fibrosis, apoptosis, arrhythmias, and cardiac dysfunction in a mouse model of arrhythmogenic cardiomyopathy.
[Circulation] |
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| Scientists developed a unique automated template matching cardiomyocyte beating model to achieve arrhythmic recognition at the single beat level with an interdigitated electrode impedance detection system.
[Microsystems & Nanoengineering] |
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| Researchers describe an assay platform by coupling human-iPSC-CMs and impedance measurement, which allowed real-time monitoring of cardiomyocyte cellular index, beating amplitude, and beating rate.
[The AAPS Journal] |
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| Investigators hypothesized that coating of 3D cardiac tissue-derived hiPSC-CMs with the extracellular matrix protein fibronectin would improve the survival of transplanted cells in the heart and improve heart function in a rat model of ischemic heart failure.
[PLOS ONE] |
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| Scientists showed that myogenic stem cells, led to functional muscle regeneration in the three animal models.
[Nature Biomedical Engineering] |
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| The authors performed a longitudinal comparison of the transcriptomic profiles of three human induced pluripotent stem cell lines that displayed differential myogenic specification, one robust and two blunted.
[Science Advances] |
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| Through a muscle-stem-cell-specific deletion, investigators showed that negative elongation factor was required for efficient muscle regeneration and stem cell pool replenishment.
[Developmental Cell] |
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| Scientists suggested that CREG1 deficiency accelerated the induction of mitophagy in the skeletal muscle. Mechanistically, gain-and loss-of-function mutations of Creg1 altered mitochondrial morphology and function, impairing mitophagy in C2C12 cells.
[Autophagy] |
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| Immuno-RNA fluorescence in situ hybridization validated loss of Tspan2 in vascular smooth muscle cells of homology-directed repair and prime editing 2 CArG box mutant mice.
[Genome Biology] |
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| Researchers showed that 17β‐estradiol‐induced mitochondrial autophagy played a crucial role in the delay of vascular senescence.
[Journal of the American Heart Association] |
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| Scientists analyzed the expression of circRNAs at the adult and embryo development stages of cattle musculus longissimus. A stringent set of 1,319 circRNAs candidates were identified, and found that 495 circRNAs were differentially expressed between embryonic and adult tissues libraries.
[Molecular Therapy-Nucleic Acids] |
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| Investigators discuss recent progress in overcoming the hurdles that should facilitate the use of human induced pluripotent stem cells (iPSC) to develop new medicines and individualize therapies for heart disease.
[Cell Chemical Biology] |
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| Scientists explore the emerging evidence that supports novel and important roles for the POU4F2/Brn-3b transcription factor in controlling cellular genes that regulate cardiometabolic function.
[Cell Death & Disease] |
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| The authors discuss the key drug-protein interactions known to be involved in cardiotoxic drug response.
[Cell Reports Medicine] |
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| The SMA Foundation and PTC Therapeutics, Inc. have entered into a new collaboration focused on regenerative medicine to further advance scientific research in SMA and other neuromuscular disorders with the goal of developing new treatments.
[The Spinal Muscular Atrophy Foundation] |
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| FibroGen, Inc. announced the initiation of LELANTOS-2, a Phase III, randomized, double-blind, placebo-controlled trial of pamrevlumab or placebo in combination with systemic corticosteroids in patients with ambulatory Duchenne muscular dystrophy.
[FibroGen, Inc.] |
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| March 22 – 24, 2021
Virtual |
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| | University of Southern Denmark – Odense M, Denmark |
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| | Mount Sinai Health System – New York, New York, United States |
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| | University of Southern Denmark – Odense M, Denmark |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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