Muscle Cell News Volume 6.11 | Mar 29 2021

May 12, 2022

2021-03-29 | MUSCN 6.11

Muscle Cell News by STEMCELL Technologies

Vol. 6.11 – 29 March, 2021

TOP STORY

The Molecular Basis for Sarcomere Organization in Vertebrate Skeletal Muscle

Investigators determined the molecular architecture of native vertebrate skeletal sarcomeres by electron cryo-tomography.
[Cell]

Full Article Graphical Abstract

PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

Cardiac Macrophages Prevent Sudden Death during Heart Stress

Scientists showed that cardiac macrophages crucially maintained cardiac impulse conduction by facilitating myocardial intercellular communication through gap junctions.
[Nature Communications]

Full Article

Generation, Functional Analysis and Applications of Isogenic Three-Dimensional Self-Aggregating Cardiac Microtissues from Human Pluripotent Stem Cells

Investigators described a protocol to generate cardiomyocytes, cardiac fibroblasts and cardiac endothelial cells, the three principal cell types in the heart, from human induced pluripotent stem cells and combined them in 3D cardiac microtissues.
[Nature Protocols]

Abstract

In Vivo Proximity Labeling Identifies Cardiomyocyte Protein Networks during Zebrafish Heart Regeneration

Researchers applied BioID2 proximity labeling to capture protein networks acting within cardiomyocytes during a key model of innate heart regeneration in zebrafish.
[eLife]

Abstract

Mitochondrial Aldehyde Dehydrogenase (ALDH2) Rescues Cardiac Contractile Dysfunction in an APP/PS1 Murine Model of Alzheimer’s Disease via Inhibition of ACSL4-Dependent Ferroptosis

In cardiomyocytes isolated from WT mice and in H9C2 myoblasts in vitro, application of Aβ decreased cell survival, compromised cardiomyocyte contractile function, and induced lipid peroxidation; ALDH2 transgene or activator Alda-1 rescued Aβ-induced deteriorating effects.
[Acta Pharmacologica Sinica]

Abstract

SKELETAL MUSCLE CELLS

Circular RNA circMYBPC1 Promotes Skeletal Muscle Differentiation by Targeting MyHC

Scientists analyzed the expression of circRNAs at the adult and embryo development stages of cattle musculus longissimus. A stringent set of 1,319 circRNAs candidates were identified, and found that 495 circRNAs were differentially expressed between embryonic and adult tissues libraries.
[Molecular Therapy-Nucleic Acids]

Abstract

Disease-Relevant Single Cell Photonic Signatures Identify S100β Stem Cells and Their Myogenic Progeny in Vascular Lesions

Researchers evaluated single cell photonics as a discriminator of cell phenotype in vitro before the presence of vascular stem cells within vascular lesions.
[Stem Cell Reviews and Reports]

Full Article Graphical Abstract

The Cyclophilin Inhibitor NIM-811 Increases Muscle Cell Survival with Hypoxia In Vitro and Improves Gait Performance following Ischemia–Reperfusion In Vivo

Investigators used an in vitro model of muscle cell ischemia in which primary human skeletal myoblasts were exposed to hypoxic conditions for six hours.
[Scientific Reports]

Full Article

A Novel Approach for the Isolation and Long-Term Expansion of Pure Satellite Cells Based on Ice-Cold Treatment

Scientists describe the ice-cold treatment method, which was a simple, economical, and efficient method for the isolation and in vitro expansion of highly pure mouse and human satellite cells.
[Skeletal Muscle]

Full Article

SMOOTH MUSCLE CELLS

ALDH1A3 Coordinates Metabolism with Gene Regulation in Pulmonary Arterial Hypertension

RNA Sequencing was applied to pulmonary arterial smooth muscle cells from pulmonary arterial hypertension patients with and without a BMPR2 mutation vs. control pulmonary arterial SMC to uncover genes required for their heightened proliferation and glycolytic metabolism.
[Circulation]

Abstract

Promyelocytic Leukemia Protein (PML) Promotes the Phenotypic Switch of Smooth Muscle Cells in Atherosclerotic Plaques of Human Coronary Arteries

To identify possible functional consequences of PML-accumulation, differentiated human coronary artery smooth muscle cells were transfected with a vector containing the intact PML-gene.
[Clinical Science]

Abstract

GDF11 Prevents the Formation of Thoracic Aortic Dissection in Mice: Promotion of Contractile Transition of Aortic SMCs

Researchers investigated the expression of growth differentiation factor 11 (GDF11) in thoracic aortic dissection and its effects on aortic smooth muscle cell phenotype transition.
[Journal of Cellular and Molecular Medicine]

Full Article

REVIEWS

Sodium Channelopathies of Skeletal Muscle and Brain

Scientists review the well-characterized genetics and pathophysiology of the periodic paralyses of skeletal muscle, and then use this information as a foundation for advancing our understanding of mutations in the structurally homologous a subunits of brain sodium channels that cause epilepsy, migraine, autism, and related co-morbidities.
[Physiological Reviews]

Abstract

Ceramides and Other Sphingolipids as Drivers of Cardiovascular Disease

Researchers discuss the body of literature suggesting that ceramides are drivers — and not merely passengers — on the road to cardiovascular disease.
[Nature Reviews Cardiology]

Abstract

Firearms-Related Skeletal Muscle Trauma: Pathophysiology and Novel Approaches for Regeneration

The authors introduce trauma ballistics and the immediate injury of skeletal muscle, followed by detailed coverage of the underlying biological mechanisms involved in regulating skeletal muscle dysfunction following injury, with a specific focus on the processes of muscle regeneration, muscle wasting and vascular impairments.
[npj Regenerative Medicine]

Full Article

INDUSTRY AND POLICY NEWS

European Medicines Agency Validates Bristol Myers Squibb’s Application for Opdivo (nivolumab) as Adjuvant Treatment for Patients with Muscle-Invasive Urothelial Carcinoma

Bristol Myers Squibb announced that the European Medicines Agency has validated its type II variation application for Opdivo for the adjuvant treatment of patients with surgically resected, high-risk muscle-invasive urothelial carcinoma.
[Bristol Myers Squibb]

Press Release

FEATURED EVENT

The Molecular Basis for Sarcomere Organization in Vertebrate Skeletal Muscle

Cardiac Macrophages Prevent Sudden Death during Heart Stress

Generation, Functional Analysis and Applications of Isogenic Three-Dimensional Self-Aggregating Cardiac Microtissues from Human Pluripotent Stem Cells

In Vivo Proximity Labeling Identifies Cardiomyocyte Protein Networks during Zebrafish Heart Regeneration

Mitochondrial Aldehyde Dehydrogenase (ALDH2) Rescues Cardiac Contractile Dysfunction in an APP/PS1 Murine Model of Alzheimer’s Disease via Inhibition of ACSL4-Dependent Ferroptosis

Circular RNA circMYBPC1 Promotes Skeletal Muscle Differentiation by Targeting MyHC

Disease-Relevant Single Cell Photonic Signatures Identify S100β Stem Cells and Their Myogenic Progeny in Vascular Lesions

The Cyclophilin Inhibitor NIM-811 Increases Muscle Cell Survival with Hypoxia In Vitro and Improves Gait Performance following Ischemia–Reperfusion In Vivo

A Novel Approach for the Isolation and Long-Term Expansion of Pure Satellite Cells Based on Ice-Cold Treatment

ALDH1A3 Coordinates Metabolism with Gene Regulation in Pulmonary Arterial Hypertension

Promyelocytic Leukemia Protein (PML) Promotes the Phenotypic Switch of Smooth Muscle Cells in Atherosclerotic Plaques of Human Coronary Arteries

GDF11 Prevents the Formation of Thoracic Aortic Dissection in Mice: Promotion of Contractile Transition of Aortic SMCs

Sodium Channelopathies of Skeletal Muscle and Brain

Ceramides and Other Sphingolipids as Drivers of Cardiovascular Disease

Firearms-Related Skeletal Muscle Trauma: Pathophysiology and Novel Approaches for Regeneration

European Medicines Agency Validates Bristol Myers Squibb’s Application for Opdivo (nivolumab) as Adjuvant Treatment for Patients with Muscle-Invasive Urothelial Carcinoma

World Stem Cell Summit

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Cell and Molecular Biologist – Cardiac Disease Research

Medicinal Chemist – Muscle-Wasting, Neurodegeneration, and Oncology

Professor – Translational Cardiology

Associate Researcher – Developmental and Regenerative Biology

Postdoctoral Position – Cardiovascular Research

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