| Vol. 6.11 – 29 March, 2021 |
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| Investigators determined the molecular architecture of native vertebrate skeletal sarcomeres by electron cryo-tomography. [Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that cardiac macrophages crucially maintained cardiac impulse conduction by facilitating myocardial intercellular communication through gap junctions. [Nature Communications] |
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| Investigators described a protocol to generate cardiomyocytes, cardiac fibroblasts and cardiac endothelial cells, the three principal cell types in the heart, from human induced pluripotent stem cells and combined them in 3D cardiac microtissues. [Nature Protocols] |
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| Researchers applied BioID2 proximity labeling to capture protein networks acting within cardiomyocytes during a key model of innate heart regeneration in zebrafish. [eLife] |
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| In cardiomyocytes isolated from WT mice and in H9C2 myoblasts in vitro, application of Aβ decreased cell survival, compromised cardiomyocyte contractile function, and induced lipid peroxidation; ALDH2 transgene or activator Alda-1 rescued Aβ-induced deteriorating effects. [Acta Pharmacologica Sinica] |
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| Scientists analyzed the expression of circRNAs at the adult and embryo development stages of cattle musculus longissimus. A stringent set of 1,319 circRNAs candidates were identified, and found that 495 circRNAs were differentially expressed between embryonic and adult tissues libraries. [Molecular Therapy-Nucleic Acids] |
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| Researchers evaluated single cell photonics as a discriminator of cell phenotype in vitro before the presence of vascular stem cells within vascular lesions. [Stem Cell Reviews and Reports] |
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| Investigators used an in vitro model of muscle cell ischemia in which primary human skeletal myoblasts were exposed to hypoxic conditions for six hours. [Scientific Reports] |
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| Scientists describe the ice-cold treatment method, which was a simple, economical, and efficient method for the isolation and in vitro expansion of highly pure mouse and human satellite cells. [Skeletal Muscle] |
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| RNA Sequencing was applied to pulmonary arterial smooth muscle cells from pulmonary arterial hypertension patients with and without a BMPR2 mutation vs. control pulmonary arterial SMC to uncover genes required for their heightened proliferation and glycolytic metabolism. [Circulation] |
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| To identify possible functional consequences of PML-accumulation, differentiated human coronary artery smooth muscle cells were transfected with a vector containing the intact PML-gene. [Clinical Science] |
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| Researchers investigated the expression of growth differentiation factor 11 (GDF11) in thoracic aortic dissection and its effects on aortic smooth muscle cell phenotype transition. [Journal of Cellular and Molecular Medicine] |
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| Scientists review the well-characterized genetics and pathophysiology of the periodic paralyses of skeletal muscle, and then use this information as a foundation for advancing our understanding of mutations in the structurally homologous a subunits of brain sodium channels that cause epilepsy, migraine, autism, and related co-morbidities. [Physiological Reviews] |
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| Researchers discuss the body of literature suggesting that ceramides are drivers — and not merely passengers — on the road to cardiovascular disease. [Nature Reviews Cardiology] |
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| The authors introduce trauma ballistics and the immediate injury of skeletal muscle, followed by detailed coverage of the underlying biological mechanisms involved in regulating skeletal muscle dysfunction following injury, with a specific focus on the processes of muscle regeneration, muscle wasting and vascular impairments. [npj Regenerative Medicine] |
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| Bristol Myers Squibb announced that the European Medicines Agency has validated its type II variation application for Opdivo for the adjuvant treatment of patients with surgically resected, high-risk muscle-invasive urothelial carcinoma. [Bristol Myers Squibb] |
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| June 14 – 18, 2021 Virtual |
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| Pfizer – Cambridge, Massachusetts, United States |
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| University of Southern Denmark – Odense M, Denmark |
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| Mount Sinai Health System – New York, New York, United States |
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| Albert Einstein College of Medicine – Bronx, New York, United States |
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