 | | Vol. 6.12 – 5 April, 2021 |
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| Researchers showed that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhanced vascular healing in rats with renal ischaemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells.
[Nature Biomedical Engineering] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| | Scientists highlighted tissue-specific differences between skeletal and cardiac muscles in their reliance on core autophagy proteins and unique roles for ULK1-ULK2 and RB1CC1 among these proteins in the development of TARDBP+ pathology.
[Autophagy] |
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| Investigators demonstrated that the Sphingosine kinase-1 silencing in neonatal mouse cardiomyocytes facilitated their postnatal maturation in both physiological and stress conditions.
[International Journal of Molecular Sciences] |
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| Researchers demonstrated that exosomes from differentiating CTX0E03 cells could reduce infarct size in mice. In an in vitro assay, these exosomes delayed cardiomyocyte mitochondrial permeability transition pore opening, which was responsible for cardiomyocyte death after reperfusion.
[Journal of Cellular and Molecular Medicine] |
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| The authors showed that the splicing factor IK contributed to normal skeletal muscle development in vivo and myogenic differentiation in vitro.
[BMC Biology] |
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| Researchers identified two markers for myogenic cell purification: CDH13, which purified most of the myogenic cells, and FGFR4, which purified a subset of muscle progenitor cells.
[Stem Cell Reports] |
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| Scientists developed a mass cytometry panel to investigate the dynamic nature of muscle regeneration at a single-cell level. Using the panel, they identified early changes in the proteome of stressed satellite and niche cells.
[Cells] |
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| Researchers investigated whether and how Piezo1 regulate the intracellular calcium homeostasis in human pulmonary arterial smooth muscle cells under normal and pulmonary arterial hypertension conditions.
[Hypertension] |
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| Investigators demonstrated that sphingosine-1-phosphate (S1P) promoted the activation of STAT3 through sphingosine-1-phosphate receptor 2, and subsequently upregulated the expression of the microRNA miR-135b, which further reduced the expression of E3 ubiquitin ligase β-transduction repeat-containing protein and led to a reduction in YAP ubiquitinated degradation in pulmonary artery smooth muscle cell.
[Journal of Biological Chemistry] |
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| The authors focus on recent advances in our understanding of doxorubicin induced regulated cardiomyocyte death pathways including autophagy, ferroptosis, necroptosis, pyroptosis and apoptosis.
[Cell Death & Disease] |
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| Scientists describe the developmental origin of smooth muscle cells within different tissues by comparing their specification and differentiation with other organs, including the cardiovascular, respiratory and intestinal systems. They also discuss the instructive roles of smooth muscle in the development of such organs through signaling and mechanical feedback mechanisms.
[Development] |
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| Ionis Pharmaceuticals, Inc. announced the initiation of a Phase III clinical trial of ION363 in patients with amyotrophic lateral sclerosis (ALS) with mutations in the fused in sarcoma gene.
[Ionis Pharmaceuticals, Inc.] |
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| PTC Therapeutics, Inc. announced that the European Commission has granted marketing authorization to Evrysdiâ„¢ for the treatment of spinal muscular atrophy (SMA) in patients two months and older.
[PTC Therapeutics, Inc.] |
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April 21 – 23, 2021
Virtual |
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| | Stanford University – Stanford, California, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | The University of Utah School of Medicine – Salt Lake City, Utah, United States |
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| | Mount Sinai Health System – New York, New York, United States |
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