Muscle Cell News Volume 6.14 | Apr 19 2021

May 12, 2022

2021-04-19 | MUSCN 6.14

Muscle Cell News by STEMCELL Technologies

Vol. 6.14 – 19 April, 2021

TOP STORY

A Form of Muscular Dystrophy Associated with Pathogenic Variants in JAG2

The authors described muscular dystrophy associated with pathogenic variants in JAG2 and suggested a disease mechanism related to Notch pathway dysfunction.
[American Journal of Human Genetics]

Abstract

Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.

PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

Ligand-Activated RXFP1 Gene Therapy Ameliorates Pressure Overload-Induced Cardiac Dysfunction

In vitro, relaxin stimulation of relaxin family peptide receptor 1 (RXFP1) – expressing cardiomyocytes induced downstream signaling resulting in PKA-specific phosphorylation of phospholamban, which was distinguishable from β-adrenergic activation.
[Molecular Therapy]

Abstract Graphical Abstract

Overexpression of circRNA SNRK Targets miR-103-3p to Reduce Apoptosis and Promote Cardiac Repair Through GSK3β/β-Catenin Pathway in Rats with Myocardial Infarction

circRNA regulated cardiomyocyte apoptosis and proliferation by acting as a miR-103-3p sponge and inducing increased expression of SNRK which could bind GSK3β to regulate its phosphorylated activity.
[Cell Death Discovery]

Full Article

SKELETAL MUSCLE CELLS

Base Editing Repairs an SGCA Mutation in Human Primary Muscle Stem Cells

Investigators provided the first evidence that autologous gene repaired human muscle stem cells could be harnessed for cell replacement therapies of muscular dystrophies.
[JCI Insight]

Abstract Graphical Abstract

Modeling Muscle Regeneration in RNA Toxicity Mice

Using a BaCl2 induced damage model, researchers found that RNA toxicity led to decreased expression of PAX7, and decreased numbers of satellite cells, the stem cells of adult skeletal muscle .
[Human Molecular Genetics]

Abstract

Valdecoxib Improves Lipid-Induced Skeletal Muscle Insulin Resistance via Simultaneous Suppression of Inflammation and Endoplasmic Reticulum Stress

Scientists suggest that valdecoxib alleviated insulin resistance through AMP-activated protein kinase/heat shock protein beta 1-mediated inhibition of inflammation and endoplasmic reticulum stress in skeletal muscle under hyperlipidemic conditions.
[Biochemical Pharmacology]

Abstract Graphical Abstract

SMOOTH MUSCLE CELLS

FAK in the Nucleus Prevents VSMC Proliferation by Promoting p27 and p21 Expression via Skp2 Degradation

Both pharmacological focal adhesion kinase (FAK) and genetic FAK inhibition reduced S-phase kinase-associated protein 2 (Skp2) expression in Vascular smooth muscle cells (VSMCs) upon injury, which significantly reduced intimal hyperplasia through elevated expression of p27 and p21.
[Cardiovascular Research]

Abstract Graphical Abstract

Loss of Transforming Growth Factor Beta Signaling in Aortic Smooth Muscle Cells Causes Endothelial Dysfunction and Aortic Hypercontractility

Scientists investigated whether loss of SMC TGF-β signaling in mice alters aortic contractile-protein levels and aortic contractility.
[Arteriosclerosis Thrombosis and Vascular Biology]

Abstract

CHOP Increases TRIB3-Dependent miR-208 Expression to Potentiate Vascular Smooth Muscle Cell Proliferation and Migration by Downregulating TIMP3 in Atherosclerosis

The authors showed that inhibition of C/EBP homologous protein (CHOP) might inhibit the proliferation and migration of vascular smooth muscle cells as well as reduce the levels of TC, TG, and LDL-C but increase the level of HDL-C through the tribbles homologue 33/microRNA-208/tissue inhibitor of metalloproteinases-3 (TIMP3) axis, thereby inhibiting the progression of atherosclerosis.
[Cardiovascular Drugs and Therapy]

Abstract

Functional NMDA Receptors Are Expressed By Human Pulmonary Artery Smooth Muscle Cells

Researchers demonstrate that both GluN1 and GluN2 subunit mRNAs were expressed in human pulmonary artery. They found GluN1 and GluN2 (A–D) subunit proteins were expressed by human pulmonary artery smooth muscle cells in vitro and in vivo.
[Scientific Reports]

Full Article

ON820MYO-Cardiac Podcast_645x110 - Cardiomyocytes

REVIEWS

The Relationship between Muscle Stem Cells and Motor Neurons

Scientists discuss the relationship between muscle stem cells and motor neurons during Drosophila neuromuscular system development and adverse impact of affected muscle stem cell–motor neuron interactions in regenerating vertebrate muscle.
[Cellular and Molecular Life Sciences]

Abstract

A New Trick for an Old Dog? Myocardial-Specific Roles for Prostaglandins as Mediators of Ischemic Injury and Repair

The authors highlight both the key historical studies that underpin modern prostaglandin research in the heart, while concurrently presenting the latest findings related to how prostaglandin metabolism and signalling impact myocardial injury and repair.
[American Journal of Physiology-Heart and Circulatory Physiology]

Abstract

INDUSTRY AND POLICY NEWS

Continued Improvements in Motor Milestones in Infants with Type I Spinal Muscular Atrophy After Two Years of Treatment with Evrysdi^™

PTC Therapeutics, Inc. announced that results from Part II of the pivotal FIREFISH trial demonstrated that infants with type 1 spinal muscular atrophy treated with Evrysdi™ obtained increases in survival and sustained improvements in achieving key motor milestones, including head control, sitting, rolling over, and further developing towards acquiring the ability to stand, and walk.
[PTC THerapeutics, Inc.]

Press Release

Actimed Therapeutics and Faraday Pharmaceuticals Announce License Agreement for S-oxprenolol

Actimed Therapeutics Ltd., announced a license agreement for S-oxprenolol to Faraday Pharmaceuticals, Inc. S-oxprenolol is one of a new class of anabolic-catabolic transforming agents under development by Actimed.
[Actimed Therapeutics Ltd.]

Press Release

FEATURED EVENT

A Form of Muscular Dystrophy Associated with Pathogenic Variants in JAG2

Ligand-Activated RXFP1 Gene Therapy Ameliorates Pressure Overload-Induced Cardiac Dysfunction

Overexpression of circRNA SNRK Targets miR-103-3p to Reduce Apoptosis and Promote Cardiac Repair Through GSK3β/β-Catenin Pathway in Rats with Myocardial Infarction

Base Editing Repairs an SGCA Mutation in Human Primary Muscle Stem Cells

Modeling Muscle Regeneration in RNA Toxicity Mice

Valdecoxib Improves Lipid-Induced Skeletal Muscle Insulin Resistance via Simultaneous Suppression of Inflammation and Endoplasmic Reticulum Stress

FAK in the Nucleus Prevents VSMC Proliferation by Promoting p27 and p21 Expression via Skp2 Degradation

Loss of Transforming Growth Factor Beta Signaling in Aortic Smooth Muscle Cells Causes Endothelial Dysfunction and Aortic Hypercontractility

CHOP Increases TRIB3-Dependent miR-208 Expression to Potentiate Vascular Smooth Muscle Cell Proliferation and Migration by Downregulating TIMP3 in Atherosclerosis

Functional NMDA Receptors Are Expressed By Human Pulmonary Artery Smooth Muscle Cells

The Relationship between Muscle Stem Cells and Motor Neurons

A New Trick for an Old Dog? Myocardial-Specific Roles for Prostaglandins as Mediators of Ischemic Injury and Repair

Continued Improvements in Motor Milestones in Infants with Type I Spinal Muscular Atrophy After Two Years of Treatment with Evrysdi^™

Actimed Therapeutics and Faraday Pharmaceuticals Announce License Agreement for S-oxprenolol

EMBO Workshop: Long-Distance Cell-Cell Signaling in Development and Disease

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Research Laboratory Tech Associate – Muscular Dystrophies

Research Scientist – Muscle Tissue Engineering

Life Sciences Researcher – Muscle Stem Cell

Associate Researcher – Developmental and Regenerative Biology

Postdoctoral Position – Cardiovascular Research

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